The nature of the receptor site for the reversible K+ channel blocking by aminopyridines

Biophysical Chemistry

Volumn 96, Issue 1, 2002, Pages 1-14

  Muñoz Caro, Camelia ^a   Niño, Alfonso ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

Aminopyridines; K+ channel blocking; Receptor site; Theoretical modelling

Indexed keywords

2 AMINOPYRIDINE; 3 AMINOPYRIDINE; 3,4 DIAMINOPYRIDINE; 4 AMINOPYRIDINE; 4 AMINOQUINOLINE; AMINOPYRIDINE DERIVATIVE; POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; ARTICLE; CYTOPLASM; ENERGY; HYDROGEN BOND; PRIORITY JOURNAL; PROTON TRANSPORT; RECEPTOR BINDING; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; AMINOPYRIDINES; BINDING SITES; ELECTROSTATICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS, VOLTAGE-GATED; THERMODYNAMICS;

EID: 0037051812     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(02)00002-9     Document Type: Article

References (40)

1. 3,4-Diaminopyridine. A potent new potassium channel blocker
2. Effects présynaptiques des aminopyridines a la junction neuromusculaire de vertébrés
3. Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?
4. Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis
5. 3-4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome
6. 4-aminopyridine improves pulmonary function in quadriplegic humans with longstanding spinal cord injury
7. The action of botulinum toxin at the neuromuscular junction
8. 4-Aminopyridine in the treatment of Alzheimer's disease
9. The actions of 4-aminopyridine on the delayed potassium current in skeletal muscle fibres
10. Potency of 3,4-diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changes
11. Site of action and active form of aminopyridines in squid axon membranes
12. Increase in evoked transmitter release from motor nerve terminals by some amino N-heterocyclic compounds, I
13. + currents in rabbit Schwann cells
14. Mechanism of 4-aminopyridine action on voltage-gated potassium channels in lymphocytes
15. Increase in evoked transmitter release from motor nerve terminals by some amino N-heterocyclic compounds. II
16. + channel blocking by aminopyridines
17. + conduction and selectivity
18. + channels
19. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors
20. Conformational behavior of α-alanine. Matrix-isolation infrared and theoretical DFT and ab initio study
21. Hydrogen bonding and density functional calculations: The B3LYP approach as the shortest way to MP2 results
22. Suitability of different levels of theory for modelling of hydroxamic acids
23. Self-consistent molecular orbital methods. XX. A basis set for correlated wave functions
24. 0 electronic spectrum of acetaldehyde
25. 0 state of acetaldehyde
26. Effect of large-amplitude vibrations on the thermodynamics of malondialdehyde
27. Ab initio study of solvated molecules: a new implementation of the polarizable continuum model
28. A new definition of cavities for the computation of solvation free energies by the polarizable continuum model
29. General atomic and molecular electronic structure system
30. The cation-π interaction
31. Why do molecules interact? The origin of electron donor-acceptor complexes, hydrogen bonding, and proton affinity
32. Electronic molecular structure, reactivity and intermolecular forces: an heuristic interpretation by means of electrostatic molecular potentials
33. Proposed procedure for using electrostatic potentials to predict an interpret nucleophilic processes
34. The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errors