Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice

Circulation Research

Volumn 90, Issue 2, 2002, Pages 197-204

  Mayr, Ursula ^a,c   Mayr, Manuel ^b,c   Li, Chaohong ^b   Wernig, Florian ^b,c   Dietrich, Hermann ^a   Hu, Yanhua ^a,c   Xu, Qingbo ^b,c  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Animal models; Apoptosis; Neointima hyperplasia; p53; Vein grafts

Indexed keywords

ALPHA ACTIN; MATRIX METALLOPROTEINASE; NITROPRUSSIDE SODIUM; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIOSCLEROSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE; JUGULAR VEIN; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; VEIN BYPASS;

ACTINS; ANIMALS; APOPTOSIS; CAROTID ARTERIES; CELL DIVISION; CELL MOVEMENT; DISEASE PROGRESSION; DNA DAMAGE; GENETIC PREDISPOSITION TO DISEASE; GRAFT OCCLUSION, VASCULAR; HETEROZYGOTE; IN SITU NICK-END LABELING; JUGULAR VEINS; MACROPHAGE-1 ANTIGEN; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MUSCLE, SMOOTH, VASCULAR; NITROPRUSSIDE; OXIDATION-REDUCTION; TRANSPLANTATION, AUTOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR SURGICAL PROCEDURES; VEINS;

EID: 0037040159     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0202.103715     Document Type: Article

References (37)

1. Aortocoronary saphenous vein graft disease: Pathogenesis, predisposition, and prevention
2. Pathobiology of intimal hyperplasia
3. Mouse Model of venous bypass graft arteriosclerosis
4. Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases
5. Regulation of the p53 tumor suppressor protein
6. Surfing the p53 network
7. Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human athero-sclerotic tissue
8. 2-terminal protein kinases in atherosclerotic lesions coincide with p53
9. Cell surface trafficking of Fas: A rapid mechanism of p53 mediated apoptosis
10. Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells
11. Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells: Potential role of p53 in regulation of vascular smooth muscle cells growth
12. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
13. Mouse model of transplant arteriosclerosis: Role of intercellular adhesion molecule-1
14. Rapid development of vein graft atheroma in ApoE-deficient mice
15. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
16. Enhanced superoxide production in experimental venous bypass graft intimal hyperplasia: Role of NAD(P)H oxidase
17. Acute hypertension induces heat-shock protein 70 gene expression in rat aorta
18. Inhibition of neointima hyperplasia of mouse vein grafts by locally applied suramin
19. Cyclic strain stress-induced mitogen-activated protein kinases (MAPK) phosphatase I expression in vascular smooth muscle cells is regulated by ras/rac-MAPK pathways
20. Ras/Rac-dependent activation of p38 mitogen-activated protein kinases in smooth muscle cells stimulated by cyclic strain stress
21. Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins
22. Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model
23. MEKK1/JNK signaling stabilizes and activates p53
24. JNK targets p53 ubiquitination and degradation in nonstressed cells
25. p53 is phosphorylated in vitro and in vivo by an ultravioletg radiation-induced protein kinase characteristic of c-Jun kinase, JNK1
26. Opposing effects of the ERK and JNK-p38 MAP kinases on apoptosis
27. Mitogen-induced p53 downregulation precedes vascular smooth muscle cell migration from healthy tunica media and proliferation
28. Reduced neointima hyperplasia in vein bypass grafts in intercellular adhesion molecule-1-deficient mice
29. Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo
30. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques
31. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice
32. Kinetics of vein graft hyperplasia: Association with tangential stress
33. Small mechanical strains selectively suppress matrix metalloproteinase-I expression by human vascular smooth muscle cells
34. Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells
35. Wild-type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13)
36. Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis
37. Biomechanical stress-induced signaling and gene expression in the development of arteriosclerosis