Acetaminophen-induced suppression of hepatic AdoMet synthetase activity is attenuated by prodrugs of L-cysteine

Toxicology Letters

Volumn 132, Issue 1, 2002, Pages 1-8

  Shirota, Frances N ^a   DeMaster, Eugene G ^a   Shoeman, Don W ^a   Nagasawa, Herbert T ^a,b  

^a VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Acetaminophen; AdoMet synthetase; Cysteine prodrugs; Hepatotoxicity

Indexed keywords

2 HYDROXYETHYLMERCAPTOCYSTEINE; ACETYLCYSTEINE; GLUTATHIONE; METHIONINE ADENOSYLTRANSFERASE; PARACETAMOL; PRODRUG; PROPYLTHIAZOLINE CARBOXYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HOMEOSTASIS; LIVER MITOCHONDRION; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; CYSTEINE; GLUTATHIONE; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; MICE; MITOCHONDRIA, LIVER; PRODRUGS;

EID: 0037035948     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00549-5     Document Type: Article

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