Evaluation of a novel shape-based computational filter for lead evolution: Application to thrombin inhibitors

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2494-2500

  Srinivasan, Jayashree ^a   Castellino, Angelo ^a   Bradley, Erin K ^a   Eksterowicz, John E ^a   Grootenhuis, Peter D J ^a   Putta, Santosh ^a   Stanton, Robert V ^a  

^a Deltagen Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN INHIBITOR;

ANALYTIC METHOD; ARTICLE; CONFORMATION; CORRELATION ANALYSIS; DATA ANALYSIS; DRUG RESEARCH; DRUG STRUCTURE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; THROMBOGENESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0037030647     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010494q     Document Type: Article

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