Syntheses and structure-activity relationships of nonnatural β-C-nucleoside 5′-triphosphates bearing an aromatic nucleobase with phenolic hydroxy groups: Inhibitory activities against DNA polymerases

Journal of Medicinal Chemistry

Volumn 45, Issue 25, 2002, Pages 5594-5603

  Aketani, Saeko ^a   Tanaka, Kentaro ^a   Yamamoto, Kaneyoshi ^b   Ishihama, Akira ^b   Cao, Honghua ^c   Tengeiji, Atsushi ^a   Hiraoka, Shuichi ^a   Shiro, Motoo ^d   Shionoya, Mitsuhiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d RIGAKU CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINO ACID; DNA POLYMERASE; NUCLEIC ACID BASE; PHENOL; PHOSPHATE; TAQ POLYMERASE;

ARTICLE; CHEMICAL REACTION; DNA STRAND; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; NUCLEOSIDES; PHENOLS; PHOSPHORIC ACID ESTERS; POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037028057     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020193w     Document Type: Article

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