Inhibition of adenovirus DNA polymerase by modified nucleoside triphosphate analogs correlate with their antiviral effects on cellular level

Medical Microbiology and Immunology

Volumn 189, Issue 2, 2000, Pages 91-95

  Mentel, Renate ^a   Kurek, Stefan ^a   Wegner, Ursula ^a   V Janta Lipinski, Martin ^b   Gürtler, Lutz ^a   Matthes, Eckart ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Antiviral activity; Human adenovirus; L Enantiomers; Modified nucleoside analogs; Polymerase

Indexed keywords

2' FLUORO 2' DEOXYCYTIDINE; 2' FLUORO 2' DEOXYGUANOSINE; 2',3' DIDEHYDRO 2',3' DIDEOXYCYTIDINE; 2',3' DIDEOXY 3' FLUOROURIDINE; 2',3' DIDEOXY BETA LEVO CYTIDINE; 2',3' DIDEOXYADENOSINE; 2',3' DIDEOXYADENOSINE TRIPHOSPHATE; 2',3' DIDEOXYCYTIDINE 5' TRIPHOSPHATE; 2',3' DIDEOXYGUANOSINE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 2',3' DIDEOXYTHYMIDINE; 2',3' DIDEOXYTHYMIDINE TRIPHOSPHATE; 3' ALPHA LEVO FLUORO 2' DEOXYADENOSINE; 3' AMINO 2' DEOXYGUANOSINE; 3' AZIDO 2' DEOXYGUANOSINE; 3' AZIDO 2' DEOXYTHYMIDINE; 3' BETA LEVO FLUORO 2' DEOXYADENOSINE; 3' BETA LEVO FLUORO 2' DEOXYGUANOSINE; 3' FLUORO 2' DEOXYADENINE; 3' FLUORO 2' DEOXYCYTIDINE; 3' FLUORO 2' DEOXYGUANOSINE; 3' FLUORO 2' DEOXYURIDINE; 3' FLUORO 5' METHYL 2' DEOXYCYTIDINE; 3' FLUOROTHYMIDINE; DNA POLYMERASE; FLUORINE DERIVATIVE; NUCLEOSIDE TRIPHOSPHATE; THYMIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE;

ANTIVIRAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENANTIOMER; ENZYME INHIBITION; FETUS; HUMAN; HUMAN ADENOVIRUS 2; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DEOXYCYTOSINE NUCLEOTIDES; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; NUCLEOTIDES; STEREOISOMERISM;

EID: 0033672824     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300000046     Document Type: Article

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