The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

Neuroscience Letters

Volumn 326, Issue 3, 2002, Pages 187-190

  Beyer, Katrin ^a   Lao, José I ^b   Gómez, Milagros ^a   Riutort, Nadal ^a   Latorre, Pilar ^a   Mate, José L ^a   Ariza, Aurelio ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b Laboratorio de Analisis Dr Echevarne   (Spain)

Author keywords

491AT polymorphism; Age at onset age; Alzheimer disease; Apolipoprotein E; Apolipoprotein E promoter; Risk factor; Th1 E47cs polymorphism

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CHI SQUARE DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; HOMOZYGOSITY; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR; COMPARATIVE STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; ONSET AGE;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 0037025116     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00355-5     Document Type: Article

References (17)

1. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene
2. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
3. Alzheimer disease and the cystatin C gene polymorphism: An association study
4. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
5. Apolipoprotein E epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region
6. Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease
7. A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease
8. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
9. Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimer's disease
10. Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease
11. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease
12. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the department of health and human services task force on Alzheimer's disease
13. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease
14. Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
15. Relative risk of Alzheimer disease and age-at-onset distributions Caucasians and Hispanics in New York City
16. Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population
17. Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease