Neonatal dexamethasone on day 7 causes mild hyperactivity and cerebellar stunting

Neurotoxicology and Teratology

Volumn 21, Issue 1, 1999, Pages 71-76

  Ferguson, Sherry A ^a   Holson, R Robert ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cerebellum; Dexamethasone; Glucocorticoids; Hyperactivity; Rat

Indexed keywords

DEXAMETHASONE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; BRAIN STEM; BRAIN WEIGHT; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DIENCEPHALON; DNA CONTENT; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HYPERACTIVITY; MALE; MAZE TEST; MOTOR ACTIVITY; NEWBORN; NONHUMAN; OLFACTORY BULB; OLFACTORY DISCRIMINATION; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TREADMILL;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; BODY WEIGHT; BRAIN; CELL COUNT; CEREBELLUM; DEXAMETHASONE; DNA; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0032969703     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(98)00029-4     Document Type: Article

References (32)

1. Benesova O., Pavlik A. Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain. Neuropharmacology. 28:1989;89-97.
2. Bohn M.C. Granule cell genesis in the hippocampus of rats treated neonatally with hydrocortisone. Neuroscience. 5:1980;2003-2012.
3. Bohn M.C., Friedrich V.L. Jr. Recovery of myelination in rat optic nerve after developmental retardation by cortisol. J. Neurosci. 2:1982;1292-1298.
4. Bohn M.C., Lauder J.M. The effects of neonatal hydrocortisone on rat cerebellar development. Dev. Neurosci. 1:1978;250-266.
5. Bohn M.C., Lauder J.M. Cerebellar granule cell genesis in the hydrocortisone-treated rat. Dev. Neurosci. 3:1980;81-89.
6. Cotterrell M., Balazs R., Johnson A.L. Effects of corticosteroids on the biochemical maturation of rat brain. Postnatal cell formation J. Neurochem. 19:1972;2151-2167.
7. De Kloet E.R., Rosenfeld P., Van Eekelen J.A.M., Sutanto W., Levine S. Stress, glucocorticoids and development. Prog. Brain Res. 73:1988;101-120.
8. DeKosky S.T., Nonneman A.J., Scheff S.W. Morphologic and behavioral effects of perinatal glucocorticoid administration. Physiol. Behav. 29:1982;895-900.
9. Ferguson S.A. A review of the neuroanatomical and functional alterations resulting from early postnatal cerebellar insults in rodents. Pharmacol. Biochem. Behav. 55:1996;663-671.
10. Ferguson S.A., Racey F.D., Paule M.G., Holston R.R. Behavioral effects of methylazoxymethanol-induced micrencephaly. Behav. Neurosci. 107:1993;1067-1076.
11. 3H] dopa in various regions of the brain J. Neurochem. 13:1966;655-669.
12. Golub M.S. Maze exploration in juvenile rats treated with corticosteroids during development. Pharmacol. Biochem. Behav. 17:1982;473-479.
13. Hansen D.K., Grafton T.F. Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro. Teratology. 43:1991;575-582.
14. Henning S.J. Plasma concentrations of total and free corticosterone during development in the rat. Am. J. Physiol. 235:1978;E451-E456.
15. Howard E. Reductions in size and total DNA of cerebrum and cerebellum in adult mice after corticosterone treatment in infancy. Exp. Neurol. 22:1968;191-208.
16. Howard E. Increased reactivity and impaired adaptability in operant behavior of adult mice given corticosterone in infancy. J. Comp. Physiol. Psychol. 85:1973;211-220.
17. Howard E., Granoff D.M. Increased voluntary running and decreased motor coordination in mice after neonatal corticosterone implantation. Exp. Neurol. 22:1968;661-673.
18. Labarca C., Paigen K. A simple rapid and sensitive DNA assay procedure. Anal. Biochem. 102:1980;344-352.
19. Lauder, J. M.; Bohn, M. C.: Thyroid hormones and corticosteroids as temporal regulators of postnatal neurogenesis in the cerebellum and hippocampus. In: Brambilla, F., Pacagni, G., de Wied, D., eds. Progress in psychoneuroendocrinology. New York: Elsevier Science Inc.; 1980.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
21. Meyer J.S. Biochemical effects of corticosteroids on neural tissues. Physiol. Rev. 65:1985;946-1020.
22. Noguchi T., Sugisaki T., Watanabe M., Kohsaka S., Tsukada Y. Effects of bovine growth hormone on the retarded cerebral development induced by neonatal hydrocortisone intoxication. J. Neurochem. 38:1982;246-256.
23. Nyakas C. Effect of neonatal corticosterone treatment on brain monoamines and rearing activity in rats. Acta Physiol. Acad. Sci. Hung. 50:1977;127-130.
24. Pavlik A., Buresova M. The neonatal cerebellum. The highest level of glucocorticoid receptors in the brain Dev. Brain Res. 12:1984;13-20.
25. Sapolsky R.M., Meaney M.J. Maturation of the adrenocortical stress response. Neuroendocrine control mechanisms and the stress hyporesponsive period Brain Res. Rev. 11:1986;65-76.
26. Schapiro S. Some physiological, biochemical, and behavioral consequences of neonatal hormone administration. Cortisol and thyroxine Gen. Comp. Endocrinol. 10:1968;214-228.
27. Trautman P.D., Meyer-Bahlburg H.F., Postelnek J., New M.I. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children. Results of a pilot study Psychoneuroendocrinology. 20:1995;439-449.
28. Tsuneishi S., Takada S., Motoike T., Ohashi T., Sano K., Nakamura H. Effects of dexamethasone on the expression of myelin basic protein, proteolipid protein, and glial fibrillary acidic protein genes in developing rat brain. Dev. Brain Res. 61:1991;117-123.
29. Turner B.B., Taylor A.N. Postnatal corticosterone treatment. Effects on reproductive development and open-field behavior Fed. Proc. 34:1975;302.
30. Vicedomini J.P., Nonneman A.J., DeKosky S.T., Scheff S.W. Perinatal glucorticoids disrupt learning. A sexually dimorphic response Physiol. Behav. 36:1986;145-149.
31. Weichsel M.E. Jr. Glucocorticoid effect upon thymidine kinase in the developing cerebellum. Pediatric Res. 8:1974;843-847.
32. Winick M., Noble A. Quantitative changes in DNA, RNA, and protein during prenatal and postnatal growth in the rat. Dev. Biol. 12:1965;451-466.