Neonatal dexamethasone on Day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits

Neurotoxicology and Teratology

Volumn 23, Issue 1, 2001, Pages 57-69

  Ferguson, Sherry A ^a   Paule, Merle G ^a   Holson, R Robert ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Activity; Dexamethasone; Glucocorticoid; Water maze

Indexed keywords

AMPHETAMINE; DEXAMETHASONE; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN TOXICITY; BRAIN WEIGHT; CEREBELLUM; COGNITIVE DEFECT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMOTIONALITY; FEMALE; HIPPOCAMPUS; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; MAZE TEST; MOTOR COORDINATION; NEWBORN; NONHUMAN; OPEN FIELD BEHAVIOR; PERINATAL DRUG EXPOSURE; PLAY; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; STARTLE REFLEX; WEIGHT REDUCTION;

AMPHETAMINE; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; BRAIN; CEREBELLUM; DARKNESS; DEXAMETHASONE; EXPLORATORY BEHAVIOR; FEMALE; HIPPOCAMPUS; LIGHT; MALE; MOTOR ACTIVITY; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 0035081027     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(00)00115-X     Document Type: Article

References (45)

1. Collaborative behavioral teratology study: Protocol design and testing procedures
2. Effect of thyroxine and cortisol on brain ornithine decarboxylase activity and swimming behavior in developing rat
3. Long-term changes in rat social behavior following treatment with trimethylolpropane
4. Brain glucocorticoid receptors and their role in behavioural teratogenicity of synthetic glucocorticoids
5. Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain
6. Recovery of myelination in rat optic nerve after developmental retardation by cortisol
7. The use of the Morris water maze in the study of memory and learning
8. Postnatally administered α-difluoromethylornithine (DFMO) has minimal effects on spatial learning and memory in adult rats
9. Minimal behavioral effects from developmental cerebellar stunting in young rats induced by postnatal treatment with α-difluoromethylornithine
10. Effect of increased maternal corticosterone during lactation on hippocampal corticosteroid receptors, stress response and learning in offspring in the early stages of life
11. Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance
12. Effects of antenatal dexamethasone administration in the infant: Long-term follow-up
13. Stress, glucocorticoids and development
14. Morphologic and behavioral effects of perinatal glucocorticoid administration
15. Behavioral depression: Opposite effects of neonatal dexamethasone and ACTH-(4-9) analogue (ORG 2766) treatments in the rat
16. Developmental α-difluoromethylornithine (DFMO) treatment has no effects on open field activity nor locomotor response to methylphenidate (METHYL) or methamphetamine (METHAMPH)
17. Methylazoxymethanol-induced microencephaly in the Brown Norway strain: Behavior and brain weight
18. Neonatal dexamethasone on day 7 causes mild hyperactivity and cerebellar stunting
19. Minimal behavioral effects from moderate postnatal lead treatment in rats
20. Effects of methylazoxymethanol-induced microencephaly on temporal response differentiation and progressive ratio responding in rats
21. Lack of effect of prefeeding on food-reinforced temporal response differentiation and progressive ratio responding
22. Effects of chlorpromazine and diazepam on time estimation behavior and motivation in rats
23. Functional effects of methylazoxymethanol-induced hypogranular cerebellar lesions in rats
24. Behavioral effects of methylazoxymethanol-induced microencephaly
25. 3H]dopa in various regions of the brain
26. Gestational stage-specific effects of retinoic acid exposure in the rat
27. Benzodiazepine-like behavioral effects following withdrawal from chronic delta-9-tetrahydrocannabinol administration in rats
28. The influence of glucocorticoids during the neonatal period on the development of play-fighting in Norway rat pups
29. Enhancement of the acoustic startle response in rats by the dopamine D1 receptor agonist SKF 82958
30. Biochemical effects of corticosteroids on neural tissues
31. Effect of corticosteroids for fetal maturation on perinatal outcomes
32. Effect of neonatal corticosterone treatment on brain monoamines and rearing activity in rats
33. Impairment of conditioned active avoidance in adult rats given corticosterone in infancy
34. The psychobiology of play: Theoretical and methodological perspectives
35. Effect of oral corticosterone administration on locomotor development of neonatal and juvenile rats
36. Feminine dimension of play fighting of rats (Rattus norvegicus) and its defeminization neonatally by androgens
37. Effects of acute ethanol on indices of cognitive-behavioral performance in rats
38. Effects of acute nicotine on several operant behaviors in rats
39. Some physiological, biochemical, and behavioral consequences of neonatal hormone administration: Cortisol and thyroxine
40. Hormonal effects on ontegeny of swimming ability in the rat: Assessment of central nervous system development
41. Effects of haloperidol and SCH23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions
42. Dexamethasone treatment on postnatal day 7: Effects on adrenal function in rats as adults
43. Effects of postnatal corticosterone treatment on reproductive development in the rat
44. Perinatal glucocorticoids disrupt learning: A sexually dimorphic response
45. Accumbens D2 modulation of sensorimotor gating in rats: Assessing anatomical localization