Synthesis, SAR and pharmacology of CP-293,019: A potent, selective dopamine D4 receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 7, 1998, Pages 725-730

  Sanner, Mark A ^a   Chappie, Thomas A ^a   Dunaiskis, Audrey R ^a   Fliri, Anton F ^a   Desai, Kishor A ^a   Zorn, Stevin H ^a   Jackson, Elisa R ^a   Johnson, Celeste G ^a   Morrone, Jean M ^a   Seymour, Patricia A ^a   Majchrzak, Mark J ^a   Faraci, W Stephen ^a   Collins, Judith L ^a   Duignan, David B ^a   Di Prete, Cecilia C ^a   Lee, Jae S ^a   Trozzi, Angela ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 7 (4 FLUOROPHENOXYMETHYL) 2 (5 FLUORO 2 PYRIMIDINYL) 2,3,4,6,7,8,9,9A OCTAHYDROPYRIDO[1,2 A]PYRAZINE; APOMORPHINE; BUSPIRONE; CLOZAPINE; CP 88703; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; SONEPIPRAZOLE; SPIPERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LOCOMOTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PREPULSE INHIBITION; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; SCHIZOPHRENIA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; APOMORPHINE; DOPAMINE ANTAGONISTS; DRUG DESIGN; HALOPERIDOL; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PYRAZINES; PYRIMIDINES; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032492711     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00108-5     Document Type: Article

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