Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 11, 2002, Pages 1501-1505

  Doherty, George A ^a   Yang, Ginger X ^a   Borges, Edite ^a   Chang, Linda L ^a   MacCoss, Malcolm ^a   Tong, Sharon ^a   Kidambi, Usha ^a   Egger, Linda A ^a   McCauley, Ermenegilda ^a   Van Riper, Gail ^a   Mumford, Richard A ^a   Schmidt, John A ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINO ACID; BETA1 INTEGRIN; CARBON; OXOACID; PHENYLALANINE DERIVATIVE; TETRAHYDROFURAN; DRUG DERIVATIVE; FURAN DERIVATIVE; LIGAND; PHENYLALANINE; SULFONAMIDE; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; THIN LAYER CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; HUMAN; IC 50; METABOLISM; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMAL; FURANS; HUMAN; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; LIGANDS; MOLECULAR WEIGHT; PHENYLALANINE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFONAMIDES; VASCULAR CELL ADHESION MOLECULE-1; ANIMALS; HUMANS;

EID: 0037013435     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00211-1     Document Type: Article

References (11)