Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2- α]benzimidazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 11, 1999, Pages 1547-1552

  Maryanoff, Bruce E ^a   Nortey, Samuel O ^a   McNally, James J ^a   Sanfilippo, Pauline J ^a   McComsey, David F ^a   Dubinsky, Barry ^a   Shank, Richard P ^a   Reitz, Allen B ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; BENZIMIDAZOLE DERIVATIVE; PYRIDO[1,2 A]BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALIA;

EID: 0033532661     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00240-1     Document Type: Article

References (13)

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10. 3-Amino-2-nitropyridine (viz. 3): Planker, S.; Warning, K.; Herbst, G. H.; Herbst, U. M.; Herbst, B. S.; Schaeffer, G. U.S. Patent 4,952,697 (1991): Chem. Abstr. 1991, 114, 81610. 4-Amino-3-nitropyridine (viz. 4): Harris, M. G.; Stewart, R. Can. J. Chem. 1977, 55, 3800. 2-Amino-3-nitropyridine (viz. 5) can be purchased.
11. 2 at δ 3.09).
12. The PBIs are poorly soluble in water unless acid-addition salts can be prepared. However, PBIs are generally quite soluble in organic solvents such as methylene chloride, methanol, DMSO, or mixtures thereof.
13. Zhang, W.; Koehler, K. F.; Harris, B.; Skolnick, P.; Cook, J. M. J. Med. Chem. 1994, 37, 745.