Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 3, 1996, Pages 333-338

  Maryanoff, Bruce E ^a   McComsey, David F ^a   Ho, Winston ^a   Shank, Richard P ^a   Dubinsky, Barry ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DIAZEPAM; PYRIDO [1,2 A]BENZIMIDAZOLE DERIVATIVE; RWJ 38293; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BEHAVIOR; BIOAVAILABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEIZURE; STRUCTURE ACTIVITY RELATION;

EID: 0030040161     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00025-X     Document Type: Article

References (13)

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11. Maryanoff, B. E.; Ho, W.; McComsey, D. F.; Reitz, A. B.; Grous, P. P.; Nortey, S. O.; Shank, R. P.; Dubinsky, B.; Taylor, R. J., Jr.; Gardocki, J. F. J. Med. Chem. 1995, 38, 16.
12. Unpublished results from our laboratories. See: Maryanoff, B. E.; McComsey, D. F.; Ho, W. World Patent application WO9404532-A1, 3 Mar 94, 74 pp.
13. 3