Overexpressions of cDNAs for β-amyloid precursor proteins 695, 751, and 770 enhance the secretion of β-amyloid precursor protein derivatives and the survival of P19-derived neurons

Journal of Neurochemistry

Volumn 66, Issue 5, 1996, Pages 2201-2204

  Fukuchi, Ken Ichiro ^a,b   Ohman, Tauni ^a,b   Dang, Nocthao ^a   Smith, Anetta C ^a   Furlong, Clement E ^a   Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Degeneration; Differentiation; Neurotrophic peptides; Proteolysis

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; PROTEIN DERIVATIVE; PROTEIN PRECURSOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEGENERATION; CELL DIFFERENTIATION; CELL SURVIVAL; EMBRYONAL CARCINOMA; ENZYME ACTIVITY; IMMUNOADSORPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; TRANSGENE;

EID: 0029986884     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66052201.x     Document Type: Article

References (23)

1. Esch F. S., Keim P. S., Beattie E. C , Blacher R. W., Culwell A. R., Oltersdorf T., McCLure D., and Ward P. J. (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248, 1122-1124.
2. Estus S., Golde T. E., Kunishita T., Blades D., Lowery D., Eisen M., Usiak M., Qu X., Tabira T., Greenberg B. D., and Younkin S. G. (1992) Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 255, 726-728.
3. Fukuchi K., Kamino K., Deeb S. S., Smith A. C., Dang T., and Martin G. M. (1992a) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Commun. 182, 165-173.
4. Fukuchi K., Kamino K., Deeb S. S., Furlong C. E., Sundstrom J. A., Smith A. C., and Martin G. M. (1992b) Expression of a carboxy-terminal region of the β-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity. Mol. Brain Res. 16, 37-46.
5. Fukuchi K., Deeb S. S., Kamino K., Ogburn C. E., Snow A. D., Sekiguchi R. T., Wight T. N., Piussan H., and Martin G. M. (1992c) Increased expression of β-amyloid protein precursor and microtubule-associated protein τ during the differentiation of murine embryonal carcinoma cells. J. Neurochem. 58, 1863-1873.
6. Golde T. E., Estus S., Younkin L. H., Selkoe D. J., and Younkin S. G. (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730.
7. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. J. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
8. Higaki J., Quon D., Zhong Z., and Cordell B. (1995) Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism. Neuron 14, 651-659.
9. Hung A. Y., Koo E. H., Haass C., and Selkoe D. J. (1992) Increased expression of β-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc. Natl Acad. Sci. USA 89, 9439-9443.
10. Hyman B. T., Tanzi R. E., Marzloff K., Barbour R., and Schenk D. (1992) Kunitz protease inhibitor-containing amyloid βprotein precursor immunoreactivity in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 51, 76-83.
11. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., and Müller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
12. Kim K. S., Miller D. L., Sapienza V. J., Chen C.-M. J., Hong V. J., and Wisniewski H. M. (1988) Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Commun. 2, 121-130.
13. Kim K. S., Wen G. Y., Bancher C., Chen C. J. M., Sapienza V. J., Hong H., and Wisniewski H. M. (1990) Detection and quantitation of amyloid β-peptide with 2 monoclonal antibodies. Neurosci. Res. Commun. 7, 113-122.
14. Mattson M. P., Cheng B., Culwell A. R., Esh F. S., Lieberburg I., and Rydel R. E. (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10, 243-254.
15. Milward E. A., Papadopoulos R., Fuller S. J., Moir R. D., Small D., Beyreuther K., and Masters C. L. (1992) The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9, 129-137.
16. Niwa H., Yamamura K., and Miyazaki J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-200.
17. Ponte P., Gonzalez-DeWhitt P., Schilling J., Miller J , Hsu D., Greenberg B., Davis K., Wallace W., Lieberburg I., Fuller F., and Cordell B. (1988) A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors. Nature 331, 525-527.
18. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., and Schenk D. (1992) Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359, 325-327.
19. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X. D., McKay D. M., Tintner R., Frangione B., and Younkin S. G. (1992) Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258, 126-129.
20. Sisodia S. S., Koo E. H., Beyreuther K., Unterbeck A., and Price D. L. (1990) Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.
21. Tamaoka A., Kalaria R. N., Lieberburg I., and Selkoe D. J. (1992) Identification of a stable fragment of the Alzheimer amyloid precursor containing the β-protein in brain microvessels. Proc. Natl. Acad. Sci. USA 89, 1345-1349.
22. Weidemann A., König G., Bunke D., Fischer P., Salbaum J. M., Masters C. L., and Beyreuther K. (1989) Identification, biogenesis, and localization of precursor of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
23. Yoshikawa K., Aizawa T., and Hayashi Y. (1992) Degeneration of in vitro post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67.