Aging: From radiant youth to an abrupt end

Current Biology

Volumn 12, Issue 7, 2002, Pages

  Rothman, Joel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

CAENORHABDITIS ELEGANS PROTEIN; CLK 2 PROTEIN, C ELEGANS; CLK-2 PROTEIN, C ELEGANS; TELOMERE BINDING PROTEIN;

AGING; ANIMAL; CAENORHABDITIS ELEGANS; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW; TELOMERE;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 0037007038     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00780-7     Document Type: Review

References (20)

1. Genetic pathways that regulate ageing in model organisms
2. A sense of the end
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4. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
5. Telomere states and cell fates
6. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
7. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein
8. C. elegans clk-2, a gene that limits life span, encodes a regulator of telomere metabolism similar to the yeast telomere binding protein Tel2p
9. Determination of life-span in Caenorhabditis elegans by four clock genes
10. Radiation-sensitive mutants of Caenorhabditis elegans
11. TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
12. The yeast telomere length regulator TEL2 encodes a protein that binds to telomeric DNA
13. The embryonic cell lineage of the nematode Caenorhabditis elegans
14. Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance
15. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
16. p53 mutant mice that display early ageing-associated phenotypes
17. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
18. Genetics of lifespan in C. elegans: Molecular diversity, physiological complexity, mechanistic simplicity
19. The genetics of caloric restriction in Caenorhabditis elegans
20. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans