Extracellular matrix and matrix metalloproteinases in atherosclerosis

Connective Tissue

Volumn 34, Issue 4, 2002, Pages 327-336

  Sasaguri, Yasuyuki ^a   Tanimoto, Akihide ^b  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b NONE

Author keywords

Atherosclerosis; Extracellular matrix; Lipid peroxides; Matrix metalloproteinases; Polymorphism

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 8; ELASTIN; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LIPID PEROXIDE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR; STROMELYSIN;

AGING; ANEURYSM; ARTERY DISEASE; ARTERY MEDIA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; HEART MUSCLE ISCHEMIA; HUMAN; MACROMOLECULE; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVIEW; VASCULAR SMOOTH MUSCLE;

EID: 0036990831     PISSN: 0916572X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (90)

1. Sasaguri, Y., Yanagi, H., Nagase, H., Nakano, R., Fukuda, S., and Morimatsu, M. (1991) Collagenase production by immortalized human aortic endothelial cells infected with simian virous 40, Virchows Archive. B Cell Pathology. 60, 91-95
2. Yanagi, H., Sasaguri, Y., Sugama, K., Morimatsu, M., and Nagase, H. (1992) production of tissue collagenase (matrix metalloproteinase 1) by human aortic smooth muscle cells in response to platelet-derived growth factor. Atherosclerosis 91, 207-216
3. Woessner, J.F. and Nagase, H. (2000) Matrix Metalloproteinase and TIMPs. Oxford University Press, New York
4. Goetzl, E., Banda, M.J., and Leppert, D. (1996) Matrix metalloproteinases in immunity. J. Immunol. 156, 1-4
5. McCawley, L.J. and Matrisian, L.M. (2001) Matrix metalloproteinases: they're not just for matrix anymore! Curr. Opin. Cell Biol. 13, 534-540
6. Libby, P. and Hansson, G.K. (1991) Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab. Invest. 64, 5-15
7. Ross, R. (1999) Atherosclerosis - An inflammatory disease. New Engl. J. Med. 340, 115-126
8. Espey, L.L. (1976) The distribution of collagenous connective tissue in rat ovarian follicles. Biol. Reprod. 14, 502-506
9. Reich, R., Tsafriri, A., and Mechanic, G.L. (1985) The involvement of collagenolysis in ovulation in the rat. Endocrinology 116, 522-527
10. Ekblom, P., Lehtonen, E., Saxen, L., and Timpl, R. (1981) Shift in collagen type as an early response to induction of the metanephric mesenchyme. J. Cell Biol. 89, 276-283
11. Nakanishi, Y., Sugiura, F., Kishi, J., and Hayakawa, T. (1986) Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland. Dev. Biol. 113, 201-206
12. Libby, P. (1995) Molecular basis of the acute coronary syndromes. Circulation 91, 2844-2850
13. Stary, H.C., Blankenhorn, D.H., and Chandler, A.B., Glagov, S., Insull, W., Jr., Richardson, M., Rosenfeld, M. E., Schaffer, S.A., Schwartz, C.J., Wagner, W.D., and Wissler, R.W. (1992) A definition of the intima of human arteries and of its atherosclerosis-prone regions. A Report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. 12, 120-134
14. Liu, X., Wu, H., Byrne, M., Krane, S., and Jaenisch, R. (1997) Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc. Natl. Acad. Sci. USA 94, 1852-1856
15. Li, D.Y., Brooke, B., Davis, E.C., Mecham, R.P., Sorensen, L.K., Boak, B.B., Eichwald, E., and Keating, M.T. (1998) Elastin is an essential determinant of arterial morphogenesis. Nature 393, 276-280
16. MacBeath, J.R.E., Kielty, C.M., and Shuttleworth, C.A. (1996) Type VIII collagen is a product of vascular smooth-muscle cells in development and disease. Biochem. J. 319, 993-998
17. Voss, B. and Rauterberg, J. (1986) Localization of collagen types I, III, IV and V, fibronectin and laminin in human arteries by the indirect immunofluorescence. Pathol. Res. Pract. 181, 568-575
18. McCullagh, K.G., Duance, V.C., and Bishop, K.A. (1980) The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta. J. Pathol. 130, 45-55
19. Nikkari, S.T., Geary, R.L., Hatsukami, T., Ferguson, M., Forough, R., Alpers, C.E., and Clowes, A.W. (1996) Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinase-1 in restenosis after carotid endarterectomy. Am. J. Pathol. 148, 777-783
20. Andreeva, E.R., Pugach, I.M., and Orekhov, A.N. (1997) Collagen-synthesizing cells in initial and advanced atherosclerotic lesions of human aorta. Atherosclerosis 130, 133-142
21. Rekhter, M.D., Zhang, K., Narayanan, A.S., Phan, S., Schork, M.A., and Gordon, D. (1993) Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. Am. J. Pathol. 143, 1634-1648
22. Katsuda, S., Okada, Y., Minamoto, T., Oda, Y., Matsui, Y., and Nakanishi, I. (1992) Collagens in human atherosclerosis, lmmunohistochemical analysis using collagen type-specific antibodies. Arterioscler. Thromb. 12, 494-502
23. Ooshima, A. and Mutagaki, Y. (1990) Collagen metabolism in atherogenesis. Ann. N. Y. Acad. Sci. 598, 582-584
24. Raines, E.W., Koyama, H., and Carragher, N.O. (2000) The extracellular matrix dynamically regulates smooth muscle cell responsiveness to PDGF. Ann. N.Y. Acad. Sci. 902, 39-51
25. Stehbens, W.E., Delahunt, B., Shozawa, T., and Gilbert-Barness, E. (2001) Smooth muscle cell depletion and collagen types in progeric arteries. Cardiovasc. Pathol. 10, 133-136
26. Vermeulen, E.G., Niessen, H.W., Bogels, M., Stehouwer, C.D., Rauwerda, J.A., and van Hinsbergh, V.W. (2001) Decreased smooth muscle cell/extracellular matrix ration of media of femoral artery in patients with atherosclerosis and hyperhomocystinemia. Arterioscler. Thromb. Vasc. Biol. 21, 573-577
27. Stary, H.C., Chandler, A.B., Dinsmore, R.E., Fuster, V., Glagov, S., Insull, W., Jr., Rosenfeld, M.E., Schwartz, C. J., Wagner, W.D., and Wissler, R.W. (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Arterioscler. Thromb. Vasc. Biol. 1,5, 1512-1531
28. Sasaguri, Y., Murahashi, N., Sugama, K., Kato, S., Hiraoka, K., Satoh, T., Isomoto, H., and morimatsu, M. (1994) Development-related changes in matrix metalloproteinase expression in human aortic smooth muscle cells. Lab. Invest. 71, 261-269
29. Morton, L.F. and Barnes, M.J. (1982) Collagen polymorphism in the normal and diseased blood vessel wall. Investigation of collagens types I, III, and V. Atherosclerosis 42, 41-51
30. Sasaguri, T., Arima, N., Tanimoto, A., Shimajiri, S., Hamada, T., and Sasaguri, T. (1998) A role of interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells. Atherosclerosis 138, 247-253
31. Galis, Z.S., Sukhova, G.K., Lark, M.W., and Libby, P. (1994) Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions on human atherosclerotic plaques. J. Clin. Invest. 94, 2493-2503
32. Nikkari, S.T., O'Brien, K.D., Ferguson, M., Hatsukami, T., Welgus, H.G., Alpers, C.E., and Clowes, A.W. (1995) Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Circulation 92, 1393-1398
33. Brown, D.L., Hibbs, M.S., Kearney, M., Loushin, C., and Isner, J.M. (1995) Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 91, 2125-2131
34. Li, Z., Li, L., Zielke, R., Cheng, L., Xiao, R., Crow, M. T., Stetler-Stevenson, W.G., Froehlich, J., and Lakatta, E. G. (1996) Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions. Am. J. Pathol. 148, 121-128
35. Matsumoto, S., Kobayashi, T., Katoh, M., Saito, S., Ikeda, Y., Kobori, M., Masuho, Y., and Watanabe, T. (1998) Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits. Relationship to lesion development. Am. J. Pathol. 153, 109-119
36. Yang, J.H., Briggs, W.H., Libby, P., and Lee, R.T. (1998) Small mechanical strains selectively suppress matrix metalloproteinase-1 expression by human vascular smooth muscle cells. J. Biol. Chem. 273, 6550-6555
37. Amento, E.P., Ehsani, N., Palmer, H., and Libby, P. (1991) Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler. Thromb. 11, 1223-1230
38. Pasterkamp, G., Schoneveld, A.H., Hijnen, D.J., de Kleijn, D.P.V., Teepen, H., van der Wal, A.C., and Borst, C. (2000) Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteinases 1, 2 and 9 in the human coronary artery. Atherosclerosis 150, 245-253
39. Busiek, D.F., Ross, F.P., McDonnell, S., Murphy, G., Matrisian, L.M., and Welgus, H.G. (1992) The matrix metalloproteinase matrilysin (PUMP) is expressed in developing human mononuclear phagocytes. J. Biol. Chem. 267, 9087-9092
40. Shapiro, S.D., Kobayashi, D.K., and Ley, T.J. (1993) Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Biol. Chem. 268, 23824-23829
41. Halpert, I., Sires, U.I., Roby, J.D., Potter-Perigo, S., Wight, T.N., Shapiro, S.D., Welgus, H.G., Wickline, S.A., and Parks, W.C. (1996) Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc. Natl. Acad. Sci. USA 93, 9748-9753
42. Thompson, R.W., Holmes, D.R., Mertens, R.A., Liao, S., Botney, M.D., Mecham, R.P., Welgus, H.G., and Parks, W.C. (1995) Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. J. Clin. Invest. 96, 318-326
43. Senior, R.M., Griffin, G.L., Fliszar, C.J., Shapiro, S.D., Goldberg, G.I., and Welgus, H.G. (1991) Human 92- and 72-kilodalton type IV collagenases are elastases. J. Biol. Chem. 266, 7870-7875
44. Woessner, J.F., Jr. (1995) Matrilysin. Methods Enzymol. 248, 485-495
45. Curci, J.A., Liao, S., Huffman, M.D., Shapiro, S.D., and Thompson, R.W. (1998) Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102, 1900-1910
46. Elmore, J.R., Keister, B.F., Franklin, D.P., Youkey, J.R., and Carey, D.J. (1998) Expression of matrix metalloproteinases and TIMPs in human abdominal aortic aneurysms. Ann. Vasc. Surg. 12, 221-228
47. Carrell, T.W.G., Burnard, K.G., Wells, G.M.A., Clements, J.M., and Smith, A. (2002) Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinases-3 are overexpressed in the wall of abdominal aortic aneurysms. Circulation 105, 477-482
48. Silence, J., Lupu, D., Collen, D., and Lijnen, H.R. (2001) Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysis-1 (MMP-3) gene inactivation. Arterioscler. Thromb. Vasc. Biol. 21, 1440-1445
49. Silence, J., Collen, D., and Lijnen, H.R. (2002) Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of matalloproteinase-1 (TIMP-1) gene. Cir. Res. 90, 897-903
50. Fuster, V., Badimon, I., Badimon, J.J., and Chesebro, J.H. (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N. Engl. J. Med. 326, 242-250
51. Henney, A.M., Wakeley, P.R., Davies, M.J., Foster, K., Hembry, R., Murphy, G., and Humphries, S. (1991) Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc. Natl. Acad. Sci. USA 88, 8154-8158
52. Kai, H., Ikeda, H., Yasukawa, H., Kai, N., Seki, Y., Kuwahara, F., Ueno, T., Sugi, K., and Imaizumi, T. (1998) Peripheral blood levels of matrix metalloproteinase-2 and -9 are elevated in patients with acute coronary syndromes. J. Am. Coll. Cardiol. 32, 368-372
53. Sukhova, G.K., Schonbeck, U., Rabkin, E., Schoen, F.J., Poole, A.R., Billinghurst, R.C., and Libby, P. (1999) Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 99, 2503-2509
54. Herman, M.P., Sukhova, G.K., Libby, P., Gerdes, N., Tang, N., Horton, D.B., Kilbride, M., Breitbart, R.E., Chun, M., and Schonbeck, U. (2001) Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma. A novel collagenolytic pathway suggested by transcriptional profiling. Circulation 104, 1899-1904
55. Shah, P.K. and Galis, Z.S. (2001) Matrix metalloproteinase hypothesis of plaque rupture. Players keep piling up but questions remain. Circulation 104, 1878-1880
56. Welgus, H.G., Campbell, E.J., Cury, J.D., Eisen, A.Z., Senior, R.M., Wilhelm, S.M., and Goldberg, G.I. (1990) Neutral metalloproteinases produced by human mononuclear phagocytes: enzyme profile, regulation, and expression during cellular development. J. Clin. Pathol. 86, 1496-1502
57. Davies, M., Richardson, P., Woolf, N., Katz, D.R., and Mann, J. (1993) Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage and smooth muscle cell content. Br. Heart J. 69, 377-381
58. van der Wal, A.C., Becker, A.E., Tigges, A.J., van der Loos, C.M., and Das, P.K. (1994) Fibrous and lipidrich atherosclerotic plaques are part of interchangeable morphologies related to inflammation. A concept. Coron. Artery Dis. 4, 463-469
59. Moreno, P.R., Falk, E., Palacios, I.F., Newell, J.B., Fuster, V., and Fallon, J.T. (1994) Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation 90, 775-778
60. Lee, R.T. and Libby, P. (1997) The unstable atheroma. Arterioscler. Thromb. Vasc. Biol. 17, 1859-1867
61. Sasaguri, Y., Morimatsu, M., Kinoshita, T., Nakashima, T., lnagaki, T., and Yagi, K. (1985) Difference in susceptibity to injury by linoleic acid hydroperoxide between endothelial and smooth muscle cells of artery. J. Appl. Biochem. 7, 70-74
62. Sasaguri, Y., Kakita, N., Murahashi, N., Kato, S., Hiraoka, K., Morimatsu, M., and Yagi, K. (1993) Atherosclerosis 100, 189-196
63. Bennett, M.R. (1999) Apoptosis of vascular smooth muscle cells in vascular remodeling and atherosclerotic plaque rupture. Cardiovasc. Res. 41, 361-368
64. Rekhter, M.D., Hicks, G.W., Brammer, D.W., Work, C. W., Kim, J.S., Gordon, D., Keiser, J.A., and Ryan, M.J. (1998) Animal model that mimics atherosclerotic plaque rupture. Cir. Res. 83, 705-713
65. Holmes, D.R., Petrinec, D., Wester, W., Thompson, R.W., and Reilly, J.M. (1996) Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat. J. Surg. Res. 63, 305-309
66. Zempo, N., Koyama, N., Kenagy, R.D., Lea, H.J., and Clowes, A.W. (1996) Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor. Arterioscler. Thromb. Vasc. Biol. 16, 28-33
67. Petrinec, D., Liao, S., Holmes, D.R., Reilly, J.M., Parks, W.C., and Thompson, R.W. (1996) Doxycycline inhibition of aneurismal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: Preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J. Vasc. Surg. 23, 336-346
68. Bellosta, S., Via, D., Canavesi, M., Pfister, P., Fumagalli, R., Paoletti, R., and Bernini, F. (1998) HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages. Arterioscler. Thromb. Vasc. Biol. 18, 1671-1678
69. Nagashima, H., Aoka, Y., Sakomura, Y., Sakuta, A., Aomi, S., Ishizuka, N., Hagiwara, N., Kawana, M., and Kasanuki, H. (2002) A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J. Vasc. Surg. 36, 158-163
70. George, S.J., Lloyd, C.T., Angelini, G.D., Newby, A.C., and Baker, A.H. (2000) Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3. Circulation 101, 296-304
71. George, S.J., Baker, A.H., Angelini, G.D., and Newby, A. C. (1998) Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointimal formation in human saphenous veins. Gene Ther. 5, 1552-1560
72. Gerge, S.J., Johnson, J.L., Angelini, G.D., Newby, A.C., and Baker, A.H. (1998) Adenovirus-mediated gene transfer of the human TIMP-I gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein. Hum. Gene Ther. 9, 867-877
73. Henney, A.M., Ye, S., Zhang, B., Jormsjo, S., Whatling, C., Eriksson, P., and Hamsten, A. (2000) Genetic diversity in the matrix metalloproteinase family. Effects on function and disease progression. Ann. N.Y. Acad. Sci. 902, 27-38
74. Simajiri, S., Arima, N., Tanimoto, A., Murata, Y., Hamada, T., Wang, K.Y., and Sasaguri, Y. (1999) Shortened microsatellite d(CA)21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene. FEBS Lett. 455, 70-74
75. Peters, D.G., Kassam, A., St Jean, P.L., Yonas, H., and Ferrell, R.E. (1999) Functional polymorphism in the matrix metalloproteinase-9 promoter as a potential risk factor for intracranial aneurysm. Stroke 30, 2612-2616
76. Lanblin, N., Bauters, C., Hermant, X., Lablanche, J.M., Helbecque, N., and Amouyel, P. (2002) Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurismal coronary artery disease. J. Am. Coll. Cardiol. 40, 43-48
77. Zhang, B., Ye, S., Herrmann, S.M., Erikson, P., de Maat, M., Evans, A., Arveiler, D., Luc, G., Cambien, F., Hamsten, A., Watkins, H., and Henney, A. (1999) Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation 99, 1788-1794
78. Pollanen, P., Karhunen, P.J., Mikkelsson, J., Laippala, P., Perola, M., Penttila, A., Mattila, K.M., Koivula, T., and Lehtimaki, T. (2001) Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene. An autopsy study. Arterioscler. Thromb. Vasc. Biol. 21, 1446-1450
79. Jormsjo, S., Ye, S., Moritz, J., Walter, D.H., Dimmeler, S., Zeiher, A.M., Henney, A., Hamsten, A., and Eriksson, P. (2000) Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease. Cir. Res. 86, 998-1003
80. Wu, L., Tanimoto, A., Murata, Y., Fan, J., Sasaguri, Y., and Watanabe, T. (2001) Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells. Biochem. Biophys. Res. Commun. 285, 300-307
81. Jormsjo, S., Whaling, C., Walter, D.H., Zeiher, A.M., Hamsten, A., and Eriksson, P. (2001) Allele-specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patients. Arterioscler. Thromb. Vasc. Biol. 21, 1834-1839
82. Ye, S., Watts, G.F., Mandalia, S., Humphries, S.E., and Henney, A.M. (1995) Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br. Heart J. 73, 209-215
83. Ye, S., Eriksson, P., Hamsten, A., Kurkinrn, M., Humphries, S.E., and Henney, A.M. (1996) Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J. Biol. Chem. 271, 13055-13060
84. Gnasso, A., Motti, C., Irace, C., Carallo, C., Liberatoscioli, L., Bernardini, S., Massoud, R., Mattioli, P.L., Federici, G., and Cortese, C. (2000) Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects. Arterioscler. Thromb. Vasc. Biol. 20, 1600-1605
85. Rauramaa, R., Vaisanen, S.B., Luong, L.A., Schmidt-Trucksass, A., Penttila, I.M., Bouchard, C., Toyry, J., and Humphries, S.E. (2000) Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 2657-2662
86. Rundek, T., Elkind, M.S., Pittman, J., Boden-Albala, B., Martin, S., Humphries, S.E., Juo, S.H.H., and Sacco, R.L. (2002) Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes. The northern Manhattan prospective cohort study. Stroke 33, 1420-1423
87. Humphries, S.E., Bauters, C., Meirhaeghe, A., Luong, L., Bertrand, M., and Amouyel, P. (2002) The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene as a risk factor for restenosis. Eur. Heart J. 23, 721-725
88. Yoon, S., Tromp, G., Vongpunsawad, S., Ronkainen, A., Juvonen, T., and Kuivaniemi, H. (1999) Genetic analysis of MMP3, MMP9, and PAI-1 in finnish patients with abdominal aortic or intracranial aneurysms. Biochem. Biophys. Res. Commun. 265, 563-568
89. Pollanen, P.J., Lehtimaki, T., Ilveskoski, E., Mikkelsson, J., Kajander, O.A., Laippala, P., Perola, M., Goebeler, S., Penttila, A., Mattila, K.M., Syrjakoski, K., Koivula, T., Nikkari, S.T., and Karhunen, P.J. (2002) Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki sudden death study. Atherosclerosis 164, 329-335
90. Terashima, M., Akita, H., Kanazawa, K., Inoeu, N., Yamada, S., Ito, K., Matsuda, Y., Takai, E., Iwai, C., Eurogane, H., Yoshida, Y., and Yokoyama, M. (1999) Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction. Circulation 99, 2217-2719