Hyperphosphatemia modestly retards parathyroid hormone suppression during calcitriol-induced hypercalcemia in normal and azotemic rats

Nephron

Volumn 92, Issue 4, 2002, Pages 883-888

  Jara, Aquiles ^a   Chacón, Cecilia ^a   Felsenfeld, Arnold J ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcitriol; Hyperparathyroidism; Parathyroid hormone; Phosphate; Renal failure

Indexed keywords

CALCITRIOL; CALCIUM; CREATININE; PARATHYROID HORMONE; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; HYPERCALCEMIA; HYPERPARATHYROIDISM; HYPERPHOSPHATEMIA; KIDNEY FAILURE; KIDNEY FUNCTION; MALE; NEPHRECTOMY; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE INTAKE; PRIORITY JOURNAL; RAT; REMISSION; STATISTICAL ANALYSIS; UREMIA;

ANIMALS; CALCITRIOL; CREATININE; DIET; HUMANS; HYPERCALCEMIA; HYPERPARATHYROIDISM; MALE; NEPHRECTOMY; PARATHYROID HORMONE; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS; UREMIA;

EID: 0036970699     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065454     Document Type: Article

References (35)

1. Albright F, Bauer W, Cockrill JR, Ellsworth R: Studies on the physiology of the parathyroid glands. II. The relation of the serum calcium to the serum phosphorus at different levels of parathyroid activity. J Clin Invest 1931;9:659-677.
2. Raisz LG, Niemann I: Effect of phosphate, calcium, and magnesium on bone resorption and hormonal responses in tissue culture. Endocrinology 1969;85:446-452.
3. Rodriguez M, Martin-Malo A, Martinez ME, Torres A, Felsenfeld AJ, Llach F: Calcemic response to parathyroid hormone in renal failure: Role of phosphorus and its effect on calcitriol. Kidney Int 1991;40:1055-1062.
4. Bover J, Jara A, Trinidad P, Rodriguez M, Felsenfeld AJ: Dynamics of skeletal resistance to PTH in the rat: Effect of renal failure and dietary phosphorus. Bone 1999;25:279-285.
5. Almaden Y, Canalejo A, Hernandez A, Ballesteros E, Garcia-Navarro S, Torres A, Rodriguez M: Direct effect of phosphorus on parathyroid hormone secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 1996;11:970-976.
6. Slatopolsky E, Finch J, Denda M, Ritter C, Zhong M, Dusso A, MacDonald PN, Brown AJ: Phosphorus restriction prevents parathyroid gland growth. J Clin Invest 1996;97:2534-2540.
7. Almaden Y, Hernandez A, Torregrosa V, Canalejo A, Sabate L, Fernandez Cruz L, Campistol JM, Torres A, Rodriguez M: High phosphate level directly stimulates parathyroid hormone secretion and synthesis by human parathyroid tissue in vitro. J Am Soc Nephrol 1998;9:1845-1852.
8. Estepa JC, Aguilera-Tejero E, Lopez I, Almaden Y, Rodriguez M, Felsenfeld AJ: Effect of phosphate on PTH secretion in vivo. J Bone Miner Res 1999;14:1848-1854.
9. De Francisco ALM, Cobo MA, Setien ME, Rodrigo E, Fresnedo GM, Unzueta MT, Amado JA, Arias M, Rodriguez M: The effect of serum phosphate on PTH secretion during hemodialysis. Kidney Int 1998;54:2140-2145.
10. Slatopolsky E, Weerts C, Thielan J, Horst R, Harter H, Martin KJ: Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-chole-calciferol in uremic patients. J Clin Invest 1984;74:2136-2143.
11. Silver J, Naveh-Many T, Mayer H, Schmelzer HJ, Popovtzer MM: Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest 1986; 78:1296-1301.
12. Quarles LD, Yohay DA, Carroll BA, Spritzer CE, Minda SA, Lobaugh BL: Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathroidism in ESRD. Kidney Int 1994;45:1710-1721.
13. Moallem E, Kilav R, Silver J, Naveh-Many T: RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998;273:5253-5259.
14. Jara A, Gonzalez S, Felsenfeld AJ, Chacon C, Valdivieso A, Jalil R, Chuaqui B: Failure of high doses of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats. Nephrol Dial Transplant 2001;16:506-512.
15. Jara A, Bover J, Lavigne J, Felsenfeld AJ: Comparison of two parathyroid hormone assays for the rat: The new immunoradiometric and the older competitive-binding assay. J Bone Miner Res 1994;9:1629-1633.
16. 3) for the treatment of psoriasis. Br J Dermatol 1996;134:1070-1078.
17. Fox J: Regulation of parathyroid hormone secretion by plasma calcium in aging rats. Am J Physiol 1991;260:E220-E225.
18. Lewin E, Almaden Y, Rodriguez M, Olgaard K: PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid glands. Kidney Int 2000;58:71-81.
19. Warren HB, Lausen NCC, Segre GV, El-Hajj G, Brown EM: Regulation of calcitropic hormones in vivo in the New Zealand white rabbit. Endocrinology 1989;125:2683-2690.
20. Mayer GP, Hurst JG: Sigmoidal relationship between parathyroid hormone secretion rate and plasma calcium concentration in calves. Endocrinology 1978;102:1036-1042.
21. Hendy GN, Stotland MA, Grunbaum D, Fraher LJ, Loveridge N, Goltzman D: Characteristics of secondary hyperparathyroidism in vitamin D-deficient dogs. Am J Physiol 1989;256: E765-E772.
22. Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM: Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab 1988;67:944-950.
23. Malberti F, Farina M, Imbasciati E: The PTH-calcium curve and the set point of calcium in primary and secondary hyperparathyroidism. Nephrol Dial Transplant 1999;14:2398-2406.
24. Cloutier M, Gascon-Barre M, D'Amour P: Chronic adaptation of dog parathyroid function to a low-calcium-high-sodium-vitamin D-deficient diet. J Bone Miner Res 1992;7:1021-1028.
25. Dunlay R, Rodriguez M, Felsenfeld A, Llach F Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis patients. Kidney Int 1989;36:1093-1098.
26. Lewin E, Wang W, Olgaard K: Reversibility of experimental secondary hyperparathyroidism. Kidney Int 1997;52:1232-1241.
27. Almaden Y, Canalejo A, Ballesteros E, Anon G, Rodriguez M: Effect of high extracellular phosphate concentration on arachidonic acid production by parathyroid tissue in vitro. J Am Soc Nephrol 2000;11:1712-1718.
28. Almaden Y, Canalejo A, Ballesteros E, Anon G, Canadillas S, Rodriguez M: Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: Effect of extracellular phosphate. J Am Soc Nephrol 2002;13: 693-698.
29. Chin J, Miller SC, Wada M, Nagano N, Nemeth EF, Fox J: Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats. J Am Soc Nephrol 2000;11: 903-911.
30. Brown AJ, Ritter CS, Finch JL, Slatopolsky EA: Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate. Kidney Int 1999;55:1284-1292.
31. 2+ sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996;81:1598-1606.
32. Gogusev J, Duchambon P, Hory B, Giovannini M, Goureau Y, Sarfati E, Drueke TB: Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997;51:328-336.
33. Silver J, Russell J, Sherwood LM: Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 1985;82:4270-4273.
34. Naveh-Many T, Silver J: Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Clin Invest 1990;86:1313-1319.
35. Shvil Y, Naveh-Many T, Barach P, Silver J: Regulation of parathyroid cell gene expression in experimental uremia. J Am Soc Nephrol 1990;1:99-104.