Effect of serum phosphate on parathyroid hormone secretion during hemodialysis

Kidney International

Volumn 54, Issue 6, 1998, Pages 2140-2145

  De Francisco, Angel L M ^a   Cobo, Maria A ^b   Setien, Maria A ^b   Rodrigo, Emilio ^b   Fresnedo, Gema F ^b   Unzueta, Maria T ^b   Amado, Jose A ^b   Ruiz, J Carlos ^b   Arias, Manuel ^b   Rodriguez, Mariano ^b  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b NONE

Author keywords

Calcium; Hemodialysis; Phosphorus; PTH; Secondary hyperparathyroidism

Indexed keywords

PARATHYROID HORMONE; PHOSPHATE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIALYSATE; FEMALE; HEMODIALYSIS; HUMAN; HYPERCALCEMIA; HYPOCALCEMIA; MALE; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL;

EID: 7844235111     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00221.x     Document Type: Article

References (35)

1. DRÜEKE T: The pathogenesis of parathyroid gland hyperplasia in chronic renal failure. (Nephrology Forum) Kidney Int 48:259-272, 1995
2. PORTALE AA, BOOTH BE, HALLORAN BP, MORRIS RC JR: Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest 3:1580-1589, 1984
3. RODRIGUEZ M, MARTIN-MALO A, MARTINEZ ME, TORRES A, FELSENFELD AJ, LLACH F: Calcemic response to parathyroid hormone in renal failure: Role of phosphorus and its effect on calcitriol. Kidney Int 40:1055-1062, 1991
4. TALLON S, BERDUD I, HERNANDEZ A, CONCEPCION MT, ALMADEN Y, TORRES A, MARTIN-MALO A, FELSENFELD AJ, ALJAMA P, RODRIGUEZ. M: The relative effects of PTH and dietary phosphorus on calcitriol production in normal and azotemic rats. Kidney Int 49:1441-1446, 1996
5. BOVER J, RODRIGUEZ M, TRINDAD P, JARA A, MARTINEZ ME, MACHADO L, LLACH F, FELSENFELD A: Factors in the development of secondary hyperparathyroidism during graded renal failure in the rat. Kidney Int 45:953-960, 1994
6. HERNANDEZ A, CONCEPCIÓN MT, RODRIGUEZ M, SALIDO E, TORRES A: High phosphate diet increases prepro-PTH mRNA independent of calcium and calcitriol in normal rats. Kidney Int 50:1872-1878, 1996
7. SLATOPLOLSKY E, CAGLAR S, PENELL JP TAGART DD, CANTERBURY JM, REISS E, BRICKER NS: On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 50:492-499, 1971
8. LOPEZ-HILKER S, DUSSO AS, RAPP NS, MARITN KJ, SLATOPOLSKY E: Phosphorous restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol. Am J Physiol 259: F432-F437, 1990
9. APARICIO M, COMBIE C, LAFAGE M, PRECIGOUT VD, POTAUX L, BOUCHET JL: In advanced renal failure dietary phosphorus restriction reverses hyperparathyroidism independent of changes in the levels of calcitriol. Nephron 63:122-123, 1993
10. YI H, FLIKUGAWA M, YAMATO H, KUMAGAI M, WATANABE T, KUROKAWA K: Prevention of enhanced parathyroid hormone secretion synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure rats: Possible direct role of phosphorus. Nephron 70:242-248, 1995
11. COMBE C, MOREL D, DE PRÉCIGOUT V, BLANCHETIER V, BOUCHET JL, POTAUX L, FOURNIER A, APARICIO M: Long-term control of hyperparathyroidism in advanced renal failure by low-phosphorus diet supplemented with calcium (without changes in plasma calcitriol). Nephron 70:287-295, 1995
12. TSUKAMOTO Y, MORIYA R, NAGABA Y, MORISHITA T, IZUMIDA I, OKUBO M: Effect of administering calcium carbonate to treat second-ary hyperparathyroidism in nondialyzed patients with chronic renal failure. Am J Kidney Dis 25:879-886, 1995
13. RODRIGUEZ M, FELSENFELD A, WILLIAMS C, PEDERSON JA, LLACH F: The effect of long term intravenous calcitriol administration on parathyroid function in hemodialysis patients. J Am Soc Nephrol 2:1014-1020, 1991
14. ALMADEN Y, CANALEJO A, HERNANDEZ A, BALLESTEROS E, GARCIANAVARRO S, TORRES A, RODRIGUEZ M: Direct effect of phophorus on parathyroid hormone secretion from whole rat parathyroid glands in vitro. J Bone Miner Res 11:970-976, 1996
15. 4) restriction prevents parathyroid cell growth in uremic rats and high phosphate directly stimulates PTH secretion in tissue culture. J Clin Invest 97:2534-2540, 1996
16. NIELSEN PK, FELDT-RASMUSEN U, OLGAARD K: A direct effect of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 11: 1762-1768, 1996
17. DE FRANCISCO ALM, AMADO JM, PRIETO M, ALCALDE G, SANZ DE CASTRO S, RUIZ JC, MORALES P, ARIAS M: Dialysis membranes and PTH changes during hemodialysis in patients with secondary hyperparathyroidism. Nephron 66:442-446, 1994
18. FENSENFELD A, JARA A, PAHL M, BOVER J, RODRIGUEZ M: Differences in the dynamics of parathyroid hormone secretion in hemodialysis patients with marked secondary hyperparathyroidism. J Am Soc Nephrol 6:1371-1378, 1995
19. BRENT GA, LEBOFF MS, SEELY EW, CONLIN PR, BROWN EM: Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab 67:944-950, 1988
20. FELSENFELD AJ, RODRIGUEZ M, DUNLAY R, LLACH F: A comparison of parathyroid-gland function in haemodialysis patients with different forms of renal osteodystrophy. Nephrol Dial Transplant 6:244-251, 1991
21. KAYE M: Hypocalcemia after an acute phosphate load is secondary to reduced calcium efflux from bone: Studies in patients with minimal renal function and varying parathyroid activity. J Am Soc Nephrol 6:273-280, 1995
22. HEBERT LA, LEMANN J, PETERSEN JR, LENNON EJ: Studies of the mechanism by which phosphate infusion lowers serum calcium concentration. J Clin Invest 45:1886-1894, 1966
23. BOURDEAU A, SOUBERBIELLE JC, BONNET P, HERVIAUX P, SACHS CH, LIEBERHERR M: Phospholipase-A2 action and arachidonic acid metabolism in calcium-mediated parathyroid hormone secretion. Endocrinology 130:1339-1344, 1992
24. ALMADEN Y, CANALEJO A, AÑON G, RODRIGUEZ M: The role of arachidonic acid in the stimulation of PTH secretion by high phosphorus, (abstract) J Am Soc Nephrol 8:570, 1997
25. 2+ and other ions as extracellular (first) messengers. Physiol Rev 71:371-411, 1991
26. KELBERG J, SLATOPOLSKY E, DELMEZ JA: Acute effects of different concentrations of dialysate magnesium during high-efficiency dialysis. Am J Kidney Dis 24:453-460, 1994
27. ALMADEN Y, HERNANDEZ A, TORREGROSA V, CANALEJO A, SABATE L, FERNANDEZ CRUZ L, CAMPISTOL JM, TORRES A, RODRIGUEZ M: High phosphate directly stimulates PTH secretion and synthesis by human parathyroid tissue. J Am Soc Nephrol (in press)
28. KILAV R, SILVER J, NAVEH-MANY T: Parathyroid hormone gene expression in hipophosphatemic rats. J Clin Invest 96:327-333, 1995
29. NAVEH-MANY T, RAHAMIMOV R, LIVNI N, SILVER J: Parathyroid cell proliferation in normal and chronic renal failure rats. The effect of calcium, phosphate and vitamin D. J Clin Invest 96:1786-1793, 1995
30. WANG Q, PALNITKAR S, PARFITT AM: Parathyroid cell proliferation in the rat: Effect of age and phosphate administration and recovery. Endocrinology 137:4558-4562, 1996
31. DENDA M, FINCH J, SLATOPOLSKY E: Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J Kidney Dis 28:596-602, 1996
32. CANALEJO A, ALMADEN Y, HERNANDEZ A, TORRES A, FENSELFELD A, RODRIGUEZ A: The effect of high phosphorus diet in parathyroid cell cycle. Nephrol Dial Transplant 13(Suppl 3):19-22, 1998
33. FINE A, Cox D, FONTAINE B: Elevation of serum phosphate affects parathyroid hormone levels in only 50% of hemodialysis patients, which is unrelated to changes in serum calcium. J Am Soc Nephrol 3:1947-1953, 1993
34. LUCAS PA, BROWN RC, WOODHEAD JS, COLES GA: 1,25- dihydroxycholecalciferol and parathyroid hormone in advanced renal failure: Effects of simultaneous protein and phosphorus restriction. Clin Nephrol 25:7-10, 1986
35. QUARLES LD, YOHAY DA, CARROLL BA, SPRITZER CE, MINDA SA, BARTHOLOMAY D, LOBAUGH BA: Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD. Kidney Int 45:1710-1721, 1994