Influence of Ex vivo expansion and retrovirus-mediated gene transfer on primary T lymphocyte phenotype and functions

Journal of Hematotherapy and Stem Cell Research

Volumn 11, Issue 6, 2002, Pages 929-940

  Sauce, Delphine ^a   Tonnelier, Nicolas ^a   Duperrier, Anne ^a   Petracca, Bruno ^a   de Carvalho Bittencourt, Marcelo ^a   Saadi, Mounir ^a   Saas, Philippe ^a   Ferrand, Christophe ^a   Herve, Patrick ^a   Tiberghien, Pierre ^a   Robinet, Eric ^a  

^a ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC G 418; B7 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2; KANAMYCIN KINASE; RETROVIRUS VECTOR; THYMIDINE KINASE;

ALLOIMMUNITY; ARTICLE; CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DNA MODIFICATION; GENE EXPRESSION; GENE TRANSFER; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOGENICITY; LYMPHOCYTE COUNT; MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SUICIDE GENE; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM;

ANTIGENS, CD; CD4-CD8 RATIO; CELL CULTURE TECHNIQUES; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE SUBSETS; RETROVIRIDAE; T-LYMPHOCYTES;

EID: 0036966191     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581602321080592     Document Type: Article

References (28)

1. Tiberghien P, CW Reynolds, J Keller, S Spence, M Deschaseaux, JM Certoux, E Contassot, WJ Murphy, R Lyons, Y Chiang, P Hervé, DL Longo and FW Ruscetti. (1994). Ganciclovir treatment of Herpes Simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation? Blood 84:1333-1341.
2. Tiberghien P, JY Cahn, A Brion, E Deconinck, E Racadot, P Hervé, N Milpied, B Lioure, E Gluckman, P Bordigoni, W Jacob, Y Chiang, S Marcus, C Reynolds and D Longo. (1997). Use of donor T-lymphocytes expressing HerpesSimplex Thymidine Kinase in allogeneic bone marrow transplantation: a phase I-II study. Hum Gene Ther 8:615-624.
3. Tiberghien P, C Ferrand, B Lioure, N Milpied, R Angonin, E Deconinck, JM Certoux, E Robinet, P Saas, B Petracca, C Juttner, CW Reynolds, DL Longo, P Hervé and JY Cahn. (2001). Administration of Herpes Simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97:63-72.
4. Robinet E, JM Certoux, C Ferrand, P Maples, A Hardwick, JY Cahn, CW Reynolds, W Jacob, P Hervé and P Tiberghien. (1998). A closed culture system for the ex vivo transduction and expansion of human T lymphocytes. J. Hematother. 7:205-215.
5. Maddens S, P Tiberghien, E Contassot, JM Certoux, D Chalmers, E Otto, P Hervé and C Ferrand. (2000). Development of a competitive PCR method for in vitro and in vivo quantification of Herpes Simplex virus thymidine kinase and neomycin resistance-expressing cells used in a clinical trial. J Hematother Stem Cell Res. 9:225-236.
6. Deacock S, A Schwarer, R Batchelor, J Goldman and R Lechler. (1992). A rapid limiting dilution assay for measuring frequencies of alloreactive, interleukin-2-producing T cells in humans. J Immunol Meth. 147:83-92.
7. Sharrock CEM, E Kaminski and S Man. (1990). Limite dilution assay of human T cells: a useful clinical tool. Immunol Today. 11:281-286.
8. - αβ bone marrow T cells with suppressor activity. J Immunol 148:373-380.
9. Howland KC, LJ Ausubel, CA London and AK Abbas. (2000). The roles of CD28 and CD40 ligand in T cell activation and tolerance. J Immunol. 164:4465-4470.
10. Vandenborre K, SW Van Gool, A Kasran, JL Ceuppens, MA Boogaerts and P Vandenberghe. (1999). Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. Immunology 98:413-421.
11. Effros RB. (2000). Long-term immunological memory against viruses. Mech Ageing Dev 121:161-171.
12. Chambers CA, MS Kuhns, JG Egen and JP Allison. (2001). CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 19:565-594.
13. Sansom DM and ND Hall. (1993). B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro. Eur J Immunol. 23:295-298.
14. Contassot E, W Murphy, R Angonin, JJ Pavy, MC Bittencourt, E Robinet, CW Reynolds, JY Cahn, P Hervé and P Tiberghien, (1998). In vivo alloreactive potential of ex vivo-expanded primary T lymphocytes. Transplantation 65:1365-1370.
15. Contassot E, C Ferrand, JM Certoux, CW Reynolds, W Jacob, Y Chiang, JY Cahn, P Hervé and P Tiberghien. (1998). Retrovirus-mediated transfer of the Herpes Simplex thymidine kinase gene in alloreactive T lymphocytes. Hum Gene Ther 9:73-80.
16. Contassot E, E Robinet, R Angonin, V Laithier, M Bittencourt, JJ Pavy, JY Cahn, P Hervé and P Tiberghien. (1998). Differential effects of cyclosporin A on the alloreactivity of fresh and ex-vivo expanded T lymphocytes. Bone Marrow Transplant 22:1097-1102.
17. Ferrand C, E Robinet, E Contassot, JM Certoux, A Lim, P Hervé and P Tiberghien. (2000). Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of the ex vivo expansion on the T cell receptor β chain hypervariable region repertoire. Hum Gene Ther 11:1151-1164.
18. Sauce D, M Bodinier, M Garin, B Petracca, N Tonnelier, A Duperrier, JV Melo, JF Apperley, C Ferrand, P Hervé, F Lang, P Tiberghien and E Robinet. (2002). Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-EBV potential through both culture-dependent and selection process-dependent mechanisms. Blood 99:1165-1173.
19. Wyss-Coray T, D Mauri-Hellweg, K Baumann, F Bettens, R Grunow and WJ Pichler. (1993). The B7 adhesion molecule is expressed on activated human T cells: functional involvement in T-T cell interactions. Eur J Immunol 23:2175-2180.
20. Riddell SR, M Elliott, DA Lewinsohn, MJ Gilbert, L Wilson, SA Manley, SD Lupton, RW Overell, TC Reynolds, L Corey and PD Greenberg. (1996). T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med 2:216-223.
21. Bonini C, G Ferrari, S Verzeletti, P Servida, E Zappone, L Ruggieri, M Ponzoni, S Rossini, F Mavilio, C Traversari and C Bordignon. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic Graft-versus-Leukemia. Science 276:1719-1724.
22. Anderson CC and P Matzinger. (2001). Immunity or tolerance: opposite outcomes of microchimerism from skin grafts. Nature Med 7:80-87.
23. Robinet E, S Fournel, A Fatmi and JP Revillard. (1996). IL-2-resistant hyporesponsiveness induced by CD4 mAbs in OKT3-activated human T cells is reversed by CD45RA trigerring. Cell Immunol 167:1-7.
24. Vincent C, S Fournel, J Wijdenes and JP Revillard. (1995). Specific hyporesponsiveness of alloreactive peripheral T cells induced by CD4 Abs. Eur J Immunol. 25:816-822.
25. Wells AD, MC Walsh, JA Bluiestone and LA Turka. (2001). Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest 108:895-903.
26. Pawelec G. (2000). Hypothesis: loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation. Mech Ageing Dev 121:181-185.
27. Fehse B, A Richters, K Putimtseva-Scharf, H Klump, H Li, W Ostertag, AR Zander and C Baum. (2000). CD34 splice variant: an attractive marker for selection of gene-modified cells. Mol Ther 1:448-456.
28. Introna M, AM Barbui, F Bambacioni, C Casati, G Gaipa, G Borleri, S Bernasconi, T Barbui, J Golay, A Biondi and A Rambaldi. (2000). Genetic modification of human T cells with CD20: A strategy to purify the lyse transduced cells with anti-CD20 antibodies. Hum Gene Ther 11:611-620.