Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation

Immunology

Volumn 98, Issue 3, 1999, Pages 413-421

  Vandenborre, K ^a   Van Gool, S W ^a   Kasran, A ^a   Ceuppens, J L ^a   Boogaerts, M A ^a   Vandenberghe, Peter ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Onderwijs en Navorsing   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOMODULATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0032701156     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00888.x     Document Type: Article

References (24)

1. 1. JUNE C.H., BLUESTONE J.A., NADLER L.M. & THOMPSON C.B. (1994) The B7 and CD28 receptor families, Immunol Today 15, 321.
2. 2. LINSLEY P.S., GREENE J.L., BRADY W., BAJORATH J., LEDBETTER J.A. & PEACH R. (1994) Human B7 (CD80) and B7 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1, 793.
3. 3. TIVOL E.A., BORRIELLO F., SCHWEITZER A.N., LYNCH W.P., BLUESTONE J.A. & SHARPE A.H. (1995) Loss of CTLA-4 leads to massive lympheproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541.
4. 4. WATERHOUSE P., PENNINGER J.M., TlMMS E. et al. (1995) Lymphoproliferative disorders with early lethality in mite deficient in Ctla-4. Science 270, 985.
5. 5. KRUMMEL M.F. & ALLISON J.P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 182, 459.
6. 6. KRUMMEL M.F. & ALLISON J.P. (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183, 2533.
7. 7. WALUNAS T.L., BAKKER C.Y. & BLUESTONE J.A. (1996) CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183, 2541.
8. 8. PEREZ V.L., VAN PARUS L., BIUCKIANS A., ZHENG X.X., STROM T.B. & ABBAS A.K. (1996) Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411.
9. 9. WALUNAS T.L., LENSCHOW D.J., BAKKER C.Y. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405.
10. 10. KARANDIKAK N.J., VANDERLUGT C.L., WALUNAS T.L., MILLER S.D. & BLUESTONE J.A. (1996) CTLA-4: a negative regulator of autoimmune disease. J Exp Med 184, 783.
11. 11. PERRIN P.J., MALDONADO J.H., DAVIS T.A., JUNE C.H. & RACKF M.K. (1996) CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J Immumol 157, 1333.
12. 12. LEACH D.R., KRUMMEL M.F. & ALLISON J.P. (1996) Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734.
13. 13. MCCOY K., CAMBERIS M. & GROS G.L. (1996) Protective immunity to nematode infection is induced by CTLA-4 blockade. J Exp Med 186, 183.
14. 14. Wu Y., GUO Y., HUANG A., ZHENG, P. & LIU Y. (1997) CTLA-4 B7 interaction is sufficient to costimulateT cell clonal expansion. J Exp Med 185, 1327.
15. 15. LINSLEY P.S., GREENE J.L., TAN P. et al. (1992) Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 176, 1595.
16. 16. GRIBBEN J.G., FREEMAN G.J., BOUSSIOTIS V.A. et al. (1995) CTLA4 mediates antigen-specific apoptosis of human T cells, froc Natl Acad Sci USA 92, 811.
17. 17. BLAIR P.J., RILEY J.L, LEVINE B,L, et al. (1998) CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X-L induction. J Immunol 160, 12.
18. 18. VANDENBORRE K., DELABIE J., BOOGAERTS M.A. et al. (1998) Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease and in Hodgkin's disease. Am J Pathol 152, 963.
19. 19. VANDENBERGHE P. & CEUPPENS J.L. (1991) Immobilized anti-CD5 together with prolonged activation of protein kinase C induce inlerleukin 2-dependent T cell growth: evidence for signal transduction through CDS. Eur J ImmunoJ 21, 251.
20. 20. ROMANI N., REIDER D., HEUER M. et al. (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 196, 137.
21. 21. BULLENS D.M.A., KASRAN A., PENG X., LORRE K. & CEUPPENS J.L. (1998) Effects of anti-IL-4 receptor monoclonal antibody on in vitro T cell cytokine levels: IL-4 production by T cells from non-atopic donors. Clin Exp Immunol 113, 320.
22. 22. VAN GOOL S.W., CEUPPENS J.L., WALTER H. & DE BOER M. (1994) Synergy between cyclosporin A and a monoclonal antibody to B7 in blocking alloantigen-induced T-cell activation. Blood 83, 176.
23. 23. FALLARINO F., FIELDS P.E. & GAJEWSKI T.F. (1998) B7 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J Exp Med 188, 205.
24. 24. LIN H., RATHMELL J.C., GRAY G.S., THOMPSON C.B., LEUDEN J.M. & ALEGRE M.L. (1998) Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice; CTLA4 can function independently of CD28. J Exp Med 188, 199.