Calcitonin gene-related peptide dilates the pregnant rat uterine vascular bed via guanylate cyclase, ATP- and Ca-sensitive potassium channels and gap junctions

Current Medical Research and Opinion

Volumn 18, Issue 8, 2002, Pages 465-470

  Vedernikov, Y P ^a   Fulep, E E ^a   Saade, G R ^a   Garfield, R E ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

cAMP; cGMP; CGRP; Gap junctions; Nitric oxide; Potassium channels; Uterine circulation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE TRIPHOSPHATE; BUFFER; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CARBENOXOLONE; DEXTRAN; GLIBENCLAMIDE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; INDOMETACIN; MDL 1233OA; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; TETRYLAMMONIUM; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; GAP JUNCTION; INHIBITION KINETICS; NONHUMAN; OXIDATION; PEPTIDE ANALYSIS; PERFUSION; PREGNANCY; PRESSURE MEASUREMENT; RAT; UTERUS BLOOD FLOW; VASODILATATION; VOLTAGE CLAMP;

EID: 0036966153     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079902125001001     Document Type: Article

References (39)

1. McEwan J, Legon S, Wimalawansa SJ, Zaida M, Dollery CT, MacIntyre I. Calcitonin gene-related peptide: a review of its biology and relevance to the cardiovascular system. In: Laragh JH, Brenner BM, Kaplan NM, eds. Endocrine Mechanisms in Hypertension. New York: Raven Press; 1989:287-306
2. Owman C. Peptidergic vasodilatory nerves in the peripheral circulation and in the vascular beds of the heart and brain. Blood Vessels 1990;27:73-93
3. Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocrin Rev 1996;17:533-85
4. DiPette D, Wimalawansa SJ. Cardiovascular action of calcitonin gene-related peptide. In: Crass MF, III, Avioli, L.V. editors. Calcitonin Gene Regulating Hormones and Cardiovascular Function. Ann Arbor: CRC Press; 1994:239-52
5. Wimalawansa SJ, MacIntyre I. Calcitonin gene-related peptide and its specific binding sites in the cardiovascular system of rats. Int J Cardiol 1988;20:29-37
6. Hirata Y, Takagi Y, Takida S, Fukuda Y, Yoshimi H, Fujita T. Calcitonin gene- related peptide receptor in cultured vascular smooth muscle and endothelial cells. Biochem Biophys Res Commun 1988;151:1113-21
7. Struthers AD, Brown MJ, Macdonald DW, Beacham JL, Stevenson JC, Morris HR, et al. Human calcitonin gene-related peptide: a potent endogenous vasodilator in man. Clin Sci 1986;70:389-93
8. Stevenson JC, Macdonald DW, Warren RC, Booker MW, Whitehead MI. Increased concentration of circulating calcitonin gene-related peptide during normal human pregnancy. Br Med J 1986;293:1329-30
9. Saggese G, Bertelloni S, Baroncelli G, Pelletti A, Benedetti U. Evaluation of a peptide family encoded by calcitonin gene in selected healthy pregnant women: a longitudinal study. Horm Res 1990;34:240-4
10. DiPette DJ, Schawarzenberger K, Ker N, Holland OB. Dose-dependent systemic and regional hemodynamic effects of calcitonin-gene related peptide. Am J Med Sci 1989;297:65-70
11. Yang D, Van Buren GA, Clark KE. Effect of calcitonin gene-related peptide on the uterine vasculature of the nonpregnant ewe. Am J Obstet Gynecol 1992;176:178-84
12. Shen YT, Pittman TJ, Buie PS, Bolduc DL, Koblan KS, Gould RJ, et al. Functional role of alpha-calcitonin gene-related peptide in the regulation of the cardiovascular system. J Pharmacol Exp Ther 2001;298:551-8
13. Florio P, Margutti A, Apa R, Miceli F, Pezzani I, Degli Uberti EC, et al. Maternal plasma calcitonin gene-related peptide levels do not change during labor and are not influenced by delivery route. J Soc Gynecol Invest 2001;8:165-8
14. Nelson SH, Steinsland OS, Suresh MS. Possible physiologic role of calcitonin gene-related peptide in the human uterine artery. Am J Obstet Gynecol 1993;168:605-11
15. + channels in the human uterine artery. Eur J Pharmacol 1993;242:255-61
16. Abdelrahman A, Wang YX, Chang SD, Pang CCY. Mechanisms of the vasodilator action of calcitonin gene related peptide in conscious rats. Br J Pharmacol 1992;106:45-8
17. Gray DW, Marshall I. Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta. Eur J Pharmacol 1992;212:37-42
18. + channels. Nature 1990;344:771-3
19. + currents in rabbit arterial smooth muscle via protein kinase A. J Physiol (Lond) 1994;475:9-13
20. + channels of vascular smooth muscle via adenylate cyclase. Basic Res Cardiol 1995;90:332-6
21. Grace GC, Dusting GJ, Kemp BE, Martin TJ. Endothelium and the vasodilator action of rat calcitonin gene-related peptide CGRP. Br J Pharmacol 1987;91:729-33
22. Tan DY, Zhang LZ, Zhao YT, Zhao D, Tang J. Involvement of nitric oxide in the vasodilator and depressor effect of calcitonin gene-related peptide. Clin Med J (Engl) 1994;107:745-9
23. Lu LF, Fiscus RR. Nitric oxide donors enhance calcitonin gene-related peptide-induced elevation of cyclic AMP in vascular smooth muscle cells. Eur J Pharmacol 1999;376:307-14
24. Anouar A, Schirar A, Germain G. Relaxant effect of calcitonin gene-related peptide (CGRP) on the nonpregnant and pregnant rat uterus. Comparison with vascular tissue. Naunyn Schmiedebergs Arch Pharmacol 1998;357:446-53
25. Lei S, Mulvany MJ, Nyborg NC. Characterization of the CGRP receptor and mechanisms of action in rat mesenteric arteries. Pharmacol Toxicol 1994;74:120-5
26. Gao YJ, Nishimura Y, Suzuki A, Nakai Y. Calcitonin gene-related peptide-induced relaxation in isolated small superior mesenteric arteries from adult stroke prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 1995;22:S109-11
27. Hong KW, Yoo SE, Yu SS, Lee JY, Rhim BY. Pharmacological coupling and functional role for CGRP receptors in the vasodilation or rat pial arterioles. Am J Physiol 1996;270:H317-23
28. Wisskirchen FM, Gray DW, Marshall I. Receptor mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h (alpha) CGRP (8-37). Br J Pharmacol 1999;128:283-92
29. Jansen-Olesen I, Kaarill L, Edvinsson L. Characterization of CGRP (1) receptors in the guinea pig basilar artery. Eur J Pharmacol 2001;414:249-58
30. Sheykhzade M, Berg Nyborg NC. Mechanism of CGRP-induced relaxation in rat intramural coronary arteries. Br J Pharmacol 2001;132:1235-46
31. G-nitro-L-arginine methyl ester. Human Reprod 1996;11:895-9
32. Grewal M, Cuevas J, Chaudhuri G, Nathan L. Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroid. Am J Physiol 1999;276:H2063-68
33. G-nitro-L-arginine methyl ester-induced hypertension. Am J Obstet Gynecol 1997;176:894-900
34. Gangula PR, Zhao H, Wimalawansa SJ, Supowit SC, DiPette DJ, Yallampalli C. Pregnancy and steroid hormones enhance the systemic and regional hemodynamic effects of calcitonin gene-related peptide in rats. Biol Reprod 2001;64:1776-83
35. Lanlua P, Decorti F, Gangula PR, Chung K, Taglialatela G, Yallampalli C. Female steroid hormones modulate receptors for nerve growth factor in rat dorsal root ganglia. Biol Reprod 2001;64:331-8
36. Takahashi Y, Vroomen M, Roman C, Heymann MA. Mechanisms of calcitonin gene-related peptide-induced increases of pulmonary blood flow in fetal sheep. Am J Physiol 2000;279:H1654-60
37. Langer B, Barthelemebs M, Grima M, Coquard C, Imbs JL. In vitro vascular reactivity of rat utero-feto-placental unit. Obstet Gynecol 1993;82:380-6
38. Edwards G, Feletou M, Gardene MJ, Thollon C, Vanhoutte PM, Weston AH. Role of gap junctions in the response to EDHF in rat and guinea pig small arteries. Br J Pharmacol 1999;128:1788-94
39. Vedernikov YP, Fulep EE, Saade GR, Garfield RE. Endothelium-derived hyperpolarizing factor (EDHF) and utero-feto-placental circulation in the rat. In: Vanhoutte, P.M, ed. EDHF 2000. London: Taylor & Francis, 2001:323-31