Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by NG-nitro-L-arginine methyl ester

Human Reproduction

Volumn 11, Issue 4, 1996, Pages 895-899

  Yallampalli, Chandrasekhar ^a   Dong, Yuan Lin ^a   Wimalawansa, Sunil J ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

CGRP; Nitric oxide; Pre eclampsia; Pregnancy; Progesterone

Indexed keywords

ANIMALIA;

CALCITONIN GENE RELATED PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; FEMALE; FETUS; FETUS MORTALITY; FETUS WEIGHT; MATERNAL HYPERTENSION; NEWBORN MORTALITY; NONHUMAN; PREECLAMPSIA; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SYSTOLIC BLOOD PRESSURE;

EID: 0030007363     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.humrep.a019274     Document Type: Article

References (39)

1. Bodelsson, G. and Stjernquist, M. (1992) Smooth muscle dilatation in the human uterine artery induced by substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide and atrial natriuretic peptide. relation to endothelium-derived relaxing substances. Hum. Reprod., 7, 1185-1188.
2. Buhimschi, I., Yallampalli, C., Dong, Y.-L. and Garfield, R E. (1995a) Involvement of a nitric oxide-cGMP pathway in control of human uterine contractility during pregnancy. Am. J. Obstet. Gynecol., 72, 1577-1584.
3. Buhimschi, I., Yallampalli, C., Chwalisz, K. and Garfield, R.E. (1995b) Preeclampsia-like conditions produced by nitric oxide inhibition: effects of L-arginine, D-arginine, and steroid hormones. Hum. Reprod., 10, 2723-2730.
4. Carter, T.L., Park, P., Pratt, K. et al (1993) Effects of CGRPa on the migration of endothelial cells of human origin. FASEB J., 7, 125.
5. Dana, H.K., Rafter, P.W , Wimalawansa, S.J. et al. (1990) CGRP and amylinamide display a proliferative effect on human umbilical endothelial cells and osteoblast-hke osteosarcoma cell-line. Biochem. Soc. Trans., 18, 1276.
6. DiPette, D. and Wimalawansa, S.J. (1994) Cardiovascular actions of calcitonin gene-related peptide. In Crass, M.F., III and Avioli, L.V. (eds), Calcium-regulating Hormones and Cardiovascular Function. CRC Press, Ann Arbor, MI, USA, pp 239-252.
7. Edvinsson, L., Fredholm, B.B., Hamel, E. et al. (1985) Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett., 58, 213-217.
8. Fickling, S.A., Williams, D., Vallance, P et al. (1993) Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and preeclampsia. Lancet, 342, 242-243.
9. Furchgott, R.F. (1984) The role of endothelium in the responses of vascular smooth muscle to drugs. Annu. Rev. Pharmacol. Toxicol., 24, 175-197
10. Girgis, S.I., Macdonald, D.W.R., Stevenson, J.C. et al. (1985) Calcitonin gene-related peptide, potent vasodilator and major product of the calcitonin gene. Lancet, 2, 14-16.
11. Grace, G.C., Dusting, G.J., Kemp, B.E. and Martin, T.J. (1987) Endothelium and the vasodilatory action of rat calcitonin gene-related peptide (CGRP). Br. J. Pharmaco., 91, 729-733.
12. Isch, J.H. and Shumacker, H.B. (1975) Arterial steal phenomena. J. Am. Med. Assoc., 232, 836.
13. Izumi, H , Yallampalli, C. and Garfield, R.E. (1993) Gestational changes in L-arginine induced relaxation of pregnant rat and human myometrial smooth muscle Am. J Obstet. Gynecol., 169, 1327-1337.
14. Jovanovic, A., Grbovic, L. and Tulic, I. (1994a) L-arginine induces relaxation of human uterine artery with both intact and denuded endothelium. Eur. J. Pharmacol., 256, 103-107.
15. Jovanovie, A., Grbovic, L. and Tulic, I. (1994b) Predominant role for nitric oxide in the relaxation induced by acetylcholine in human uterine artery. Hum Reprod., 9, 387-393.
16. Knight, K B. and Keith, R.E. (1992) Calcium supplementation on normotensive and hypertensive pregnant women. Am. J. Clin. Nutr., 55, 891-895.
17. McCarthy, A.L., Woolfson, R.G., Raju, S.K. and Poston, L. (1993) Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am. J. Obstet. Gynecol., 168, 1323-1330.
18. Molnar, M. and Hertelendy, F. (1992) N-Nitro-L-arginine, an inhibitor of nitric oxide synthesis increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am. J. Obstet. Gynecol., 166, 1560-1567.
19. Molnar, M., Sütö, T., Tóth, T. and Hertelendy, F. (1994) Prolonged blockade of nitric oxide synthesis in gravid rats produced sustained hypertension, proteinuria, thrombocytopenia and intrauterine growth retardation. Am J. Obstet. Gynecol., 170, 1458-1466.
20. Moncada, S., Radomsik, M.W. and Palmer, R.M.J, (1988) Endothelium-derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacol., 37, 2495-2501.
21. Nelson, S H., Steinsland, O.S. and Suresh, M.S. (1993) Possible physiologic role of calcitonin gene-related peptide in the human uterine artery. Am. J. Obstet. Gynecol., 168, 605-611.
22. Page, E W. (1939) The relation between hydrated moles, relative ischemia of the gravid uterus and placental origin of eclampsia. Am. J. Obstet. Gynecol., 37, 291
23. Rees, D D., Palmer, R.M.J., Schulz, R. et al. (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol., 101, 746-752
24. Rosenfeld, M.G., Mernod, J.J., Amara, S.G. et al. (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature, 304, 129-135
25. Seligman, S.P., Buyon, J.P., Clancy, R.M. et al. (1994) The role of nitric oxide in the pathogenesis of preeclampsia. Am. J. Obstet. Gynecol., 171, 944-948.
26. Stevenson, J.C., Macdonald, D.W.R., Warren, R.C. et al. (1986) Increased concentration of calcitonin gene-related peptide during normal human pregnancy. Br. Med. J., 293, 1329-1330
27. G-monomethyl-L-arginine on the blood pressure of pithed normotensive and spontaneously hypertensive rats. Clin. Exp. Hyperten. Theory Practice, A14, 527-546.
28. Tippins, J.R. (1986) CGRP: a neuropeptide from the calcitonin gene is the most potent vasodilator known. J. Hyperten., 4, S102-S105.
29. Wimalawansa, S.J. (1993a) Effects of neonatal capsaicin therapy on plasma contents and tissue levels of immunoreactive CGRP. Peptides, 14, 247-252.
30. Wimalawansa, S.J. (1993b) Anti-hypertensive effects of oral calcium supplementation is mediated through the potent vasodilator CGRP. Am J. Hyperten., 6, 996-1002.
31. Wimalawansa, S.J. (1996) CGRP, calcitonin, amylin and adrenomadullin 'super family'. Crit. Rev. Neurobiol., in press.
32. Wimalawansa, S.J. and MacIntyre, I. (1988a) Heterogeneity of plasma calcitonin gene-related peptide: partial characterisation of immunoreactive forms Peptides. 9, 407-410.
33. Wimalawansa, S.J. and MacIntyre, I. (1988b) Calcitonin gene-related peptide and its specific binding sites in the cardiovascular system of the rat. Int. J. Cardiol., 20, 29-37.
34. Wimalawansa, S.J., Emson, P.C. and MacIntyre, I. (1987) Regional distribution of calcitonin gene-related peptide and its specific binding sites in the rat, with particular reference to the nervous system. Neuroendocrinology, 46, 131-136.
35. Wimalawansa, S.J., Morris, H.R. and MacIntyre, I. (1989) Both α- and β-calcitonin gene-related peptides are present in plasma, cerebrospinal fluid and spinal cord in man. J. Mol. Endocrinol., 3, 247-252.
36. Yallampalli, C. and Garfield, R.E (1993) Inhibition of nitric oxide synthesis in rats during pregnancy produces symptoms identical to preeclampsia. Am. J Obstet. Gynecol., 169, 1316-1320
37. Yallampalli, C., Garfield, R.E. and Byam-Smith, M. (1993) Nitric oxide inhibits uterine contractility during pregnancy but not during delivery. Endocrinology, 133, 1899-1902.
38. Yallampalli, C., Byam-Smith, M., Nelson, S.O. and Garfield, R.E. (1994a) Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus. Endocrinology, 134, 1971-1974.
39. Yallampalli, C., Izumi, H., Byam-Smith, M. and Garfield, R.E. (1994b) An L-arginine-nitric oxide cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy. Am. J. Obstet. Gynecol., 170, 173-185.