7-Substituted-[1,4]dioxano[2,3-g]quinazolines as inhibitors of epidermal growth factor receptor kinase

Archiv der Pharmazie

Volumn 335, Issue 10, 2002, Pages 487-494

  Lee, Jae Yeol ^a   Park, Yong Kyu ^a   Seo, Seon Hee ^a   Yang, Beom Seok ^a   Park, Hokoon ^a   Lee, Yong Sup ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

A431; Antitumor; Dioxane; EGFR; Inhibitor; Quinazoline; Tyrosine kinase; Water solubility

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 7 (4 METHYL 1 PIPERAZINO)METHYL 4 [(3' BROMOPHENYL)AMINO] 1,4 DIOXANO[2,3 G]QUINAZOLINE; 7 (DIETHANOLAMINO)METHYL 4 [(3' IODOPHENYL)AMINO] 1,4 DIOXANO[2,3 G]QUINAZOLINE; 7 METHOXYMETHYL 1,4 DIOXANO[2,3 G]QUINAZOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

HUMANS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036964279     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200290003     Document Type: Article

References (16)

1. M. Yamada, T. Ikeuchi, H. Hatanaka, Prog. Neurobiol. 1997, 51, 19-37.
2. K. Hickey, D. Grehan, I. M. Reid, S. O'Briain, T. N. Walsh, T. P. J. Hennessy, Cancer 1994, 74, 1693-1698.
3. D. W. Fry, A. J. Kraker, A. McMichael, L. A. Ambroso, J. M. Nelson, W. R. Leopold, R. W. Connors, A. J. Bridges, Science 1994, 265, 1093-1095.
4. G. W. Rewcastle, W. A. Denny, A. J. Bridges, H. Zhou, D. R. Cody, A. McMichael, D. W. Fry, J. Med. Chem. 1995, 38, 3482-3487.
5. W. H. J. Ward, P. N. Cook, A. M. Slater, D. H. Davies, G. A. Holdgate, L. R. Green, Biochem. Pharmacol. 1994, 48, 659-666.
6. A. Wissner, B. D. Johnson, M. B. Floyd, D. B. Kitchen, U.S. Patent 5,760,041, 1998; CAN 127:190750.
7. C. M. Discafani, M. L. Carroll, M. B. Floyd Jr., I. J. Hollander, Z. Husain, B. D. Johnson, D. Kitchen, M. K. May, M. S. Malo, A. A. Minnick Jr., R. Nilakantan, R. Shen, Y.-F. Wang, A. Wissner, L. M. Greenberger, Biochem. Pharmacol. 1999, 57, 917-925.
8. M. W. Kunkel, K. E. Hook, C. T. Howard, S. Przybranowski, B. J. Roberts, W. L. Elliott, W. R. Leopold, Invest. New Drugs 1996, 13, 295-302.
9. A. M. Thompson, A. J. Bridges, D. W. Fry, A. J. Kraker, W. A. Denny, J. Med. Chem. 1995, 38, 3780-3788.
10. G. W. Rewcastle, B. D. Palmer, A. M. Thompson, A. J. Bridges, D. J. Fry, A. J. Kraker, W. A. Denny, J. Med. Chem. 1996, 39, 1823-1835.
11. A. M. Thompson, D. K. Murray, W. L. Elliott, D. W. Fry, J. Nelson, H. D. H. Showalter, B. J. Roberts, P. W. Vincent, W. A. Denny, J. Med. Chem. 1997, 40, 3915-3925.
12. J. Y. Lee, Y. K. Park, S. H. Seo, I.-S. So, H.-K. Chung, B.-S. Yang, S. J. Lee, H. Park, Y. S. Lee, Arch. Pharm. Pharm. Med. Chem. 2001, 334, 357-360.
13. A. G. Suárez, Tetrahedron Lett. 1999, 40, 3523-3526.
14. P. M. Heertjes, B. J. Knape, H. C. A. van Beek, K. van den Boogaart, J. Chem. Soc. 1957, 3445-3447.
15. A. Wissner, D. M. Berger, D. H. Boschelli, M. B. Floyd, Jr. L. M. Greenberger, B. C. Gruber, B. D. Johnson, N. Mamuya, R. Nilakantan, M. F. Reich, R. Shen, H-R. Tsou, E. Upeslacis, Y. F. Wang, B. Wu, F. Ye, N. Zhang, J. Med. Chem. 2000, 43, 3244-3256.
16. B. D. Smaill, B. D. Palmer, G.W. Rewcastle, W. A. Denny, D. J. McNamara, E. M. Dobrusin, A. J. Bridges, H. Zhou, H. D. H. Showalter, R. T. Winters, W. R. Leopold, D. W. Fry, J. M. Nelson, V. Slintak, W. L. Elliot, B. J. Roberts, P. W. Vincent, S. J. Patmore, J. Med. Chem. 1999, 42, 1803-1815.