1,4-Dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase

Archiv der Pharmazie

Volumn 334, Issue 11, 2001, Pages 357-360

  Lee, Jae Yeol ^a   Park, Yong Kyu ^a   Seo, Seon Hee ^b   So, In Seop ^b   Chung, Hee Kyung ^a   Yang, Beom Seok ^b   Lee, Sook Ja ^a   Park, Hokoon ^b   Lee, Yong Sup ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Hankuk University of Foreign Studies   (South Korea)

Author keywords

1,4 Dioxane; 4 Anilinoquinazolines; A431 cell; Antitumor agent; EGFR; Tyrosine kinases

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 [(3 BROMOPHENYL)AMINO] 6,7 ETHYLENEDIOXYQUINAZOLINE; 4 [(3 CHLOROPHENYL)AMINO] 6,7 ETHYLENEDIOXYQUINAZOLINE; 4 [(3 TRIFLUOROMETHYLPHENYL)AMINO] 6,7 ETHYLENEDIOXYQUINAZOLINE; 4 [(3,5 DIMETHYLPHENYL)AMINO] 6,7 ETHYLENEDIOXYQUINAZOLINE; 4 [(4 CHLORO 3 FLUOROPHENYL)AMINO] 6,7 ETHYLENEDIOXYQUINAZOLINE; 4 ANILINOQUINAZOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIOXANE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; UTERUS CANCER;

ANTINEOPLASTIC AGENTS; CELL DIVISION; DIOXANES; HUMANS; PROTEIN-TYROSINE KINASES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035666237     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4184(200112)334:11<357::AID-ARDP357>3.0.CO;2-Q     Document Type: Article

References (11)