Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice

Investigational New Drugs

Volumn 13, Issue 4, 1995, Pages 295-302

  Kunkel, Mark W ^a   Hook, Kenneth E ^a   Howard, Curtis T ^a   Przybranowski, Sally ^a   Roberts, Billy J ^a   Elliott, William L ^a   Leopold, Wilbur R ^a  

^a PFIZER INC   (United States)

Author keywords

A431 xenograft; epidermal growth factor; kinase inhibitor; signal transduction; tyrosine kinase

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENCY; DRUG TUMOR LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; EPIDERMOID TUMOR; HUMAN; HUMAN TISSUE; IMMUNE DEFICIENCY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; XENOGRAFT;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; ENZYME INHIBITORS; HUMANS; MICE; MICE, NUDE; NEOPLASMS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029582641     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/BF00873135     Document Type: Article

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