Novel autoantibodies for the diagnosis of rheumatoid arthritis;Neue autoantikörper in der diagnostik der rheumatoiden arthritis

Zeitschrift fur Rheumatologie

Volumn 61, Issue 6, 2002, Pages 667-673

  Steiner, Günter ^a   Smolen, Josef S ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anti BiP; Anti RA33; Autoantibodies; CCP; Citrullinated antigens; Diagnostic markers; Glucose 6 phosphate isomerase (GPI)

Indexed keywords

ANTIBODY; AUTOANTIBODY; FILAGGRIN; KERATIN ANTIBODY; PEPTIDE; PROTEIN ANTIBODY; RHEUMATOID FACTOR;

ANTIBODY SPECIFICITY; AUTOIMMUNITY; DIAGNOSTIC PROCEDURE; MEDICAL SCHOOL; REVIEW; RHEUMATOID ARTHRITIS; SERODIAGNOSIS;

ANTIBODY SPECIFICITY; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BIOLOGICAL MARKERS; HEAT-SHOCK PROTEINS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KERATINS; PREDICTIVE VALUE OF TESTS; RHEUMATOID FACTOR;

EID: 0036962672     PISSN: 03401855     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00393-002-0470-y     Document Type: Review

References (46)

1. Baeten D, Peene I, Union A, Meheus L, Sebbag M, Serre G, Veys EM, De Keyser F (2001) Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum 44:2255-2262
2. Bizzaro N, Mazzanti G, Tonutti E, Villalta D, Tozzoli R (2001) Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem 47:1089-1093
3. Behrens S, Bergholz R, Schumann F, Schmidt W, Valet G, Burmester GR, Engel JM, Bläss S (2001) Immunomics in rheumatoid arthritis. Arthritis Rheum 44, No 9 (Suppl):abstract 2073
4. Bläss S, Union A, Raymackers J, Schumann F, Ungethum U, Muller Steinbach S, De Keyser F, Engel JM, Burmester GR (2001) The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis Rheum 44:761-771
5. Cordonnier C, Meyer O, Palazzo E, de Bandt M, Elias A, Nicaise P, Haim T, Kahn MF, Chatellier G (1996) Diagnostic value of anti-RA33 antibody, antikeratin antibody, antiperinuclear factor and antinuclear antibody in early rheumatoid arthritis: comparison with rheumatoid factor [see comments]. Br J Rheumatol 35:620-624
6. Corrigall VM, Bodman Smith MD, Fife MS, Canas B, Myers LK, Wooley P, Soh C, Staines NA, Pappin DJ, Berlo SE, van Eden W, van Der Zee R, Lanchbury JS, Panayi GS (2001) The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol 166:1492-1498
7. Fritsch R, Eselböck D, Skriner K, Jahn-Schmid B, Scheinecker C, Bohle B, Tohidast-Akrad M, Hayer S, Neumüller J, Pinol-Roma S, Smolen J, Steiner G (2002) Characterization of autoreactive T cells to the autoantigens RA33 (hnRNP A2) and filaggrin in patients with rheumatoid arthritis. J Immunol 169:1068-1076
8. Girbal Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, Simon M, Senshu T, Masson Bessiere C, Jolivet Reynaud C, Jolivet M, Serre G (1999) The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol 162:585-594
9. Goldbach Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, Steiner G, Rosen A, Zhang C, Menard HA, Zhou ZJ, Palosuo T, Van Venrooij WJ, Wilder RL, Klippel JH, Schumacher HR Jr, Ei Gabalawy HS (2000) Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2:236-243
10. Hassfeld W, Steiner G, Graninger W, Witzmann G, Schweitzer H, Smolen JS (1993) Autoantibody to the nuclear antigen RA33: a marker for early rheumatoid arthritis. Br J Rheumatol 32:199-203
11. Hassfeld W, Steiner G, Studnicka Benke A, Skriner K, Graninger W, Fischer I, Smolen JS (1995) Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus. Arthritis Rheum 38:777-785
12. Houssien DA, Jonsson T, Davies E, Scott DL (1998) Rheumatoid factor isotypes, disease activity and the outcome of rheumatoid arthritis: comparative effects of different antigens. Scand J Rheumatol 27:46-53
13. Hueber W, Hassfeld W, Smolen JS, Steiner G (1999) Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis. Rheumatology Oxford 38:155-159
14. Akiyama K, Senshu T (1999) Dynamic aspects of protein deimination in developing mouse epidermis. Exp Dermatol 8:177-186
15. Ji H, Korganow AS, Mangialaio S, Hoglund P, Andre I, Luhder F, Gonzalez A, Poirot L, Benoist C, Mathis D (1999) Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems. Immunol Rev 16:9139-9146
16. Jonsson T, Valdimarsson H (1998) What about IgA rheumatoid factor in rheumatoid arthritis? Ann Rheum Dis 57:63-64
17. Kassahn D, Kolb C, Solomon S, Bochtler P, Illges H (2002) Few human autoimmune sera detect GPI. Nature Immunol 3:411-412
18. Kindas Mugge I, Steiner G, Smolen JS (1993) Similar frequency of autoantibodies against 70-kD class heat-shock proteins in healthy subjects and systemic lupus erythematosus patients. Clin Exp Immunol 92:46-50
19. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87:811-822
20. Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van't Hof M, van de Putte LB, van Rijswijk MH, van Venrooij WJ, van Riel PL (2000) The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 43:1831-1835
21. Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T, Serre G (2001) The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 166:4177-4184
22. Matsumoto I, Staub A, Benoist C, Mathis D (1999) Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286:1732-1735
23. Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, Mathis D, Benoist C (2002) How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 3:360-365
24. Moseley P (2000) Stress proteins and the immune response. Immunopharmacology 48:299-302
25. Nell VPK, Machold KP, Hueber W, Eberl G, Hiesberger H, Hoefler E, Smolen JS, Steiner G (2002) The diagnostic significance of autoantibodies in patients with very early rheumatoid arthritis. Arthritis Rheum 45, No 9 (Suppl):abstract 1450
26. Pritzker LB, Joshi S, Gowan JJ, Harauz G, Moscarello MA (2000) Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D. Biochemistry 39:5374-5381
27. Richter Cohen M, Steiner G, Smolen JS, Isenberg DA (1998) Erosive arthritis in systemic lupus erythematosus: analysis of a distinct clinical and serological subset. Br J Rheumatol 37:421-424
28. Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HEN, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ (2002) Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med 8:295-301
29. Schaller M, Burton DR, Ditzel HJ (2001) Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol 2:746-753
30. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998) Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 101:273-281
31. Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, van Venrooij WJ (2000) The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 43:155-163
32. Scott DL (2000) Prognostic factors in early rheumatoid arthritis. Rheumatology 124-129
33. Simon M, Girbal E, Sebbag M, Gomes Daudrix V, Vincent C, Salama G, Serre G (1993) The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies", autoantibodies specific for rheumatoid arthritis. J Clin Invest 92:1387-1393
34. Skriner K, Sommergruber WH, Tremmel V, Fischer I, Barta A, Smolen JS, Steiner G (1997) Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. J Clin Invest 100:127-135
35. Smolen JS (1996) Autoantibodies in rheumatoid arthritis. In: van Venrooij WJ, Maini RN (eds) Manual of Biological Markers of Disease (Vol C); Kluwer Academic Publishers, Dordrecht Boston London, pp 1.1/1-18
36. Smolen JS, Steiner G (1998) Are autoantibodies active players or epiphenomena? Curr Opin Rheumatol 10:201-206
37. Smolen JS, Steiner G (2001) Rheumatoid arthritis is more than cytokines: autoimmunity and rheumatoid arthritis. Arthritis Rheum 44:2218-2220
38. Steiner G, Hartmuth K, Skriner K, Maurer Fogy I, Sinski A, Thalmann E, Hassfeld W, Barta A, Smolen JS (1992) Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. J Clin Invest 90:1061-1066
39. Steiner G, Skriner K, Smolen JS (1996) Autoantibodies to the A/B proteins of the heterogeneous nuclear ribonucleoprotein complex: novel tools for the diagnosis of rheumatic diseases. Int Arch Allergy Immunol 111:314-319
40. Steiner G, Smolen J (2002) Autoantibodies in rheumatoid arthritis and their clinical significance. Arthritis Res 4(Suppl 2):S1-5
41. Tishler M, Shoenfeld Y (1996) Anti-heat-shock protein antibodies in rheumatic and autoimmune diseases. Semin Arthritis Rheum 26:558-563
42. Union A, Meheus L, Humbel RL, Conrad K, Steiner G, Moereels H, Pottel H, Serre G, De Keyser F (2002) Identification of citrullinated rheumatoid arthritis-specific epitopes in natural filaggrin relevant for antifilaggrin autoantibody detection by LINE immunoassay. Arthritis Rheum 46
43. van Venrooij WJ, Pruijn GJ (2000) Citrullination: a small change for a protein with great consequences for rheumatoid arthritis. Arthritis Res 2:249-251
44. Xu W, Seiter K, Feldman E, Ahmed T, Chiao JW (1996) The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase. Blood 87:4502-4506
45. Youinou P, Serre G (1995) The antiperinuclear factor and antikeratin antibody systems. Int Arch Allergy Immunol 107:508-518
46. Zugel U, Kaufmann SH (1999) Immune response against heat shock proteins in infectious diseases. Immunobiology 201:22-35