How are hepatocytes sensitized to apoptosis?

Journal of Gastroenterology

Volumn 37, Issue 12, 2002, Pages 1094-1096

  Nagaki, Masahito ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; CYCLOHEXIMIDE; DACTINOMYCIN; FAS ANTIGEN; FAS LIGAND; GALACTOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P55; PROTEIN P75; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; CARBOXY TERMINAL SEQUENCE; DOWN REGULATION; EDITORIAL; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HUMAN; IMMUNOREACTIVITY; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER FAILURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENSITIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; HEPATECTOMY; HEPATOCYTES; LIVER REGENERATION; MALE; MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 0036958518     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350200187     Document Type: Editorial

References (21)

1. Osthoff SK, Krammer PH, Droge W. Divergent signaling via APO-1/FAS and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J 1994;13:4587-96.
2. Leist M, Gantner F, Nauman H, Bluethmann H, Vogt K, Brigelius-Flohé R, et al. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology 1997;112:923-34.
3. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993;364:806-9.
4. Leist M, Gantner F, Künstle G. The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol Med 1996;2:109-24.
5. Nagaki M, Sugiyama A, Osawa Y, Naiki T, Nakashima S, Nozawa Y, et al. Lethal hepatic apoptosis mediated by tumor necrosis factor receptor, unlike Fas-mediated apoptosis, requires hepatocyte sensitization in mice. J Hepatol 1999;31:997-1005.
6. Wong GHW, Goeddel DV. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol 1995;152: 1751-5.
7. Xia M, Xu C, Ji S, Xue S. Shedding of Fas ectodomain that affects apoptosis of hepatocytes occurring in regenerating liver. J Gastroenterol 2002;37:1042-7.
8. Takerara T, Hayashi N, Mita E, Kanto T, Tatsumi T, Sasaki Y, et al. Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of TNFα. Hepatology 1998;27:1643-51.
9. Kiba T, Saito S, Numata K, Sekihara H. Fas (APO-1/CD95) mRNA is down-regulated in liver regeneration after hepatectomy in rats. J Gastroenterol 2000;35:34-8.
10. Galle PR, Hofmann WJ, Walczak H, Schaller H, Otto G, Stremmel W, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 1995;182:1223-30.
11. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, et al. Tumor necrosis factor α in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 2000;119:446-60.
12. Kim PK, Wang Y, Gambotto A, Kim YM, Weller R, Zuckerbraun BS, et al. Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli. J Biol Chem 2002;277:38855-62.
13. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 1996;274:782-4.
14. Wang C-Y, Mayo MW, Baldwin Jr AS. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 1996;274:784-7.
15. Van Antwerp DJ, Martin SJ, Kafri T, Green D, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science 1996;274:787-9.
16. Beg A, Sha AW, Bronson R, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167-70.
17. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol 1998;18:6353-64.
18. Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hyashi H, et al. Tumor necrosis factor α prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not Fas-mediated apoptosis: role of nuclear factor-κB. Hepatology 2000; 32:1272-9.
19. Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-κB in human endothelial cells. J Biol Chem 2000;275:15458-65.
20. Hatano E, Brenner DA. Akt protects mouse hepatocytes from TNF-α- and Fas-mediated apoptosis through NF-κB activation. Am J Physiol Gastrointest Liver Physiol 2002;282:G1357-68.
21. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, et al. TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 2001;167:173-80.