Regulation of human immunodeficiency virus type 1 gene expression and pathogenesis by CCAAT/enhancer binding proteins in cells of the monocyte/macrophage lineage

Journal of NeuroVirology

Volumn 8, Issue SUPPL. 2, 2002, Pages 21-26

  Hogan, Tricia H ^a   Krebs, Fred C ^a   Wigdahl, Brian ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

C EBP; HIV 1; Monocyte macrophage

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CYTOKINE; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CORRELATION ANALYSIS; CYTOKINE RELEASE; DEMENTIA; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; GENE EXPRESSION; GENE REPLICATION; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE DEFICIENCY; IMMUNOCOMPETENT CELL; INFLAMMATION; LONG TERMINAL REPEAT; MACROPHAGE; MONOCYTE; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; VIRUS PATHOGENESIS;

CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGES; MONOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036957557     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280290167911     Document Type: Article

References (23)

1. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T (1990). A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9: 1897-1906.
2. Ambrosino C, Ruocco MR, Chen X, Mallardo M, Baudi F, Trematerra S, Quinto I, Venuta S, Scala G (1997). HIV-1 Tat induces the expression of the interleukin-6, (IL6) gone by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors. J Biol Chem 272: 14883-14892.
3. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (1996). A novel human CCAAT/enhancer binding protein gene, C/EBP epsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. Genomics 35: 30-38.
4. Bretz JD, Williams SC, Baer M, Johnson PF, Schwartz RC (1994). C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line. Proc Natl Acad Sci USA 91: 7306-7310.
5. Cao Z, Umek RM, McKnight SL (1991). Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5: 1538-1552.
6. Cooper C, Henderson A, Artandi S, Avitahl N, Calame K (1995). Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res 23: 4371-4377.
7. Henderson AJ, Calame KL (1997). CCAAT/enhancer binding protein (C/EBP) sites are required for HIV-1 replication in primary macrophages but not CD4(+) T cells. Proc Natl Acad Sci USA 94: 8714-8719.
8. Henderson AJ, Connor RI, Calame KL (1996). C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines. Immunity 5: 91-101.
9. Henderson AJ, Zou X, Calame KL (1995). C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes. J Virol 69: 5337-5344.
10. Hogan TH, Stauff D, Krebs FC, Gartner S, Quiterio S, Wigdahl B (2003). Structural and functional evolution of HIV-1 LTR C/EBP sites and their use as molecular markers for GNS disease progression. J Neuro Virol 9(1) In press.
11. Hu HM, Baer M, Williams SC, Johnson PF, Schwartz RC (1998). Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1. J Immunol 160: 2334-2342.
12. Krebs FC, Goodenow MM, Wigdahl B (1997). Neuroglial ATF/CREB factors interact with the human immunodeficiency virus type 1 long terminal repeat. J Neuro Virol 3(suppl. 1): S28-S32.
13. Krebs FC, Mehrens D, Pomeroy S, Goodenow MM, Wigdahl B (1998). Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes. J Biomed Sci 5: 31-44.
14. Landschulz WH, Johnson PF, Adashi EY, Graves BJ, McKnight SL (1988). Isolation of a recombinant copy of the gene encoding C/EBP [published erratum appears in Genes Dev 1994, 8: 1131]. Genes Dev 2: 786-800.
15. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S (1993). Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90: 10193-10197.
16. Morosetti R, Park DJ, Chumakov AM, Grillier I, Shiohara M, Gombart AF, Nakamaki T, Weinberg K, Koeffler HP (1997). A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation. Blood 90: 2591-2600.
17. Ross HL, Gartner S, McArthur JC, Corboy JR, McAllister JJ, Millhouse S, Wigdahl B (2001). HIV-1 LTR C/EBP binding site sequence configurations preferentially encountered in brain lead to enhanced C/EBP factor binding and increased LTR-specific activity. J Neuro Virol 7: 235-249.
18. Roux P, Alfieri C, Hrimech M, Cohen EA, Tanner JE (2000). Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression. J Virol 74: 4658-4665.
19. Ruocco MR, Chen X, Ambrosino C, Dragonetti E, Liu W, Mallardo M, De Falco G, Palmieri C, Franzoso G, Quinto I, Venuta S, Scala G (1996). Regulation of HIV-1 long terminal repeats by interaction of C/EBP (NF-IL6) and NF-kappaB/Rel transcription factors. J Biol Chem 271: 22479-22486.
20. Scott LM, Civin CI, Rorth P, Friedman AD (1992). A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80: 1725-1735.
21. Tesmer VM, Rajadhyaksha A, Babin J, Bina M (1993). NF-IL6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1. Proc Natl Acad Sci USA 90: 7298-7302.
22. Wedel A, Ziegler-Heitbrock HW (1995). The C/EBP family of transcription factors. Immunobiology 193: 171-185.
23. Williams SC, Du Y, Schwartz RC, Weiler SR, Ortiz M, Keller JR, Johnson PF (1998). C/EBP epsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage colony-stimulating factor receptor genes. J Biol Chem 273: 13493-13501.