C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines

Immunity

Volumn 5, Issue 1, 1996, Pages 91-101

  Henderson, Andrew J ^a   Connor, Ruth I ^b   Calame, Kathryn L ^a  

^a The New York Presbyterian Hospital   (United States)

^b AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; NUCLEAR FACTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; VIRUS INDUCTION; VIRUS REPLICATION;

EID: 0030200963     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80313-1     Document Type: Article

References (64)

1. Akira, S., and Kishimoto, T. (1992). IL-6 and NF-IL-6 in acute-phase response and viral infection. Immunol. Rev. 127, 25-50.
2. Alcami, J., Lain de Lera, T., Folgueira, L., Pedraza, M.A., Jacque, J.M., Bachelerie, F., Noriega, A.R., Hay, R.T., Harrich, D., Gaynor, R.B., Virelizier, J.L., and Arenzana-Seisdedos, F. (1995). Absolute dependence on κB responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4T lymphocytes. EMBO J. 14, 1552-1560.
3. Baeuerle, P.A., and Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-180.
4. Breen, E.G., Rezai, A.R., Nakajima, K., Beall, G.N., Mitsuyasu, R.T., Hirano, T., Kishimoto, T., and Martinez-Maza, O. (1990). Infection with HIV is associated with elevated IL-6 levels and production. J. Immunol. 144, 480-484.
5. Cao, Z., Umek, R., and McKnight, S. (1991). Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5, 1538-1552.
6. Chen, B.K., Saksela, K., Andino, R., and Baltimore, D. (1994). Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses. J. Virol. 68, 654-60.
7. Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J., and Rutter, W.J. (1979). Isolation of biological ribonucleic acid from sources enriched in ribonucleases. Biochemistry 18, 5294-5298.
8. Cooper, C., Johnson, D., Roman, C., Avitahl, N., Tucker, P., and Calame, K. (1992). The C/EBP family of transcriptional activators is functionally important for Ig Vh promoter activity in vivo and in vitro. J. Immunol. 149, 3225-3231.
9. Cooper, C., Berrier, A., Roman, C., and Calame, K. (1994). Limited expression of C/EBP family proteins during B-lymphocyte development: negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later. J. Immunol. 153, 5049-5058.
10. Descombes, P., and Schibler, U. (1991). A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67, 569-579.
11. Dustin, M.L., Rothlein, R., Bhan, A.K., Dinarello, C.A., and Springer, T.A. (1986). Induction of IL1 and interferon-gamma: tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J. Immunol. 137, 245-254.
12. Embretson, J., Zupancic, M., Ribas, J.L., Burke, A., Racz, P., Tenner-Racz, K., and Haase, A.T. (1993). Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362.
13. Fauci, A. (1993). Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science. 262, 1011-1018.
14. Fauci, A.S. (1988). The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239, 480-484.
15. Folkes, T.M., Justement, J., Kinter, A., Dinarello, C.A., and Fauci, A.S. (1987). Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 238, 800-802.
16. Folkes, T.M., Justement, J., Kinter, A., Schnittman, S., Orenstein, J., Poli, G., and Fauci, A.S. (1988). Characterization of a promonocytic clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate. J. Immunol. 140, 1117-1122.
17. Gartner, S., Markovits, P., Markovitz, B.M., Kaplan, M.H., Gallo, R.C., and Popovic, M. (1986). The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233, 215-219.
18. Goff, S., Traktman, P., and Baltimore, D. (1981). Isolations and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J. Virol. 38, 239-248.
19. Gossen, M., and Bujard, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.
20. Griffin, G.E., Leung, K., Folks, T.M., Kunkel, S., and Nabel, G.J. (1989). Activation of HIV gene expression during monocyte differentiation by induction of NF-κB. Nature 339, 70-73.
21. Griffin, G., Leung, K., Folks, T., Kunkel, S., and Nabel, G. (1991). Induction of NF-κB during monocyte differentiation is associated with activation of HIV-gene expression. Res. Virol. 142, 233-238.
22. Harrich, D., Garcia, J., Wu, F., Mitsuyasu, R., Gonazalez, J., and Gaynor, R. (1989). Role of Sp1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J. Virol. 63, 2585-2591.
23. Heinzel, S.S., Krysan, P.J., Carlos, M.P., and DuBridge, R.B. (1988). Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells. J. Virol. 62, 3738-3746.
24. Henderson, A., Zou, X., and Calame, K. (1995). C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes. J. Virol. 69, 5337-5344.
25. Hoffman, R.A., King, P.C., Hansen, W.P., and Goldstein, G. (1980). Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood. Proc. Natl. Acad. Sci. USA 77, 4914-4917.
26. Kim, J.Y.H., Gonzalez-Scarano, F., Ziechner, S.L., and Alwine, J.C. (1993). Replication of type 1 human immunodeficiency virus containing linker substitution mutations in the -201 to -130 region of the long terminal repeat. J. Virol. 67, 1658-1662.
27. Kinter, A.L., Poli, G., Maury, W., Folks, T.M., and Fauci, A.S. (1990). Direct and cytokine-mediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells. J. Virol. 64, 4306-12.
28. Koyanagi, Y., O'Brien, W., Zhao, J.Q., Golde, D.W., Gasson, J.C., and Chen, I.S.Y. (1988). Cytokines alter HIV-1 from primary mononuclear phagocytes. Science 241, 1673-1675.
29. LeClair, K.P., Blanar, M.A., and Sharp, P.A. (1992). The p50 subunit of NF-κB associates with the NF-IL-6 transcription factor. Proc. Natl. Acad. Sci. USA 89, 8145-8149.
30. Leonard, J., Parrot, C., Buckler-White, A., Turner, W., Ross, E., Martin, M., and Rabson, A. (1989). The NF-κB binding sites in the HIV-1 LTR are not required for virus infectivity. J. Virol. 65, 4919-4924.
31. Lu, Y., Stenzel, M., Sodroski, J.G., and Haseltine, W.A. (1989). Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication. J. Virol. 63, 4115-4119.
32. Lubbert, M., Hermann, F., and Koeffler, P. (1991). Expression and regulation of myeloid-specific genes and markers in normal and leukemic myeloid cells. Blood 77, 909-917.
33. McCune, J.M. (1995). Viral latency in HIV disease. Cell 82, 183-188.
34. Metz, R., and Ziff, E. (1991). cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev. 10, 1754-1766.
35. Morgenstern, J.P., and Laud, H. (1990). Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucl. Acid Res. 18, 3587-3596.
36. Nabel, G., and Baltimore, D. (1987). An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326, 711-713.
37. Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., and Akira, S. (1993). Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL-6. Proc. Natl. Acad. Sci. USA 90, 2207-2211.
38. Natsuka, S., Akira, S., Nishio, Y., Hashimoto, S., Sugita, T., Isshiki, H., and Kishimoto, T. (1992). Macrophage differentiation-specific expression of NF-IL-6, a transcription factor for Interleukin-6. Blood 79, 460-466.
39. Parrot, C., Seidner, T., Duh, E., Leonard, J., Theodore, T., Buckler-White, A., Martin, M., and Rabson, A. (1991). Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes. J. Virol. 65, 1414-1419.
40. Pear, W.S., Nolan, G.P., Scott, M.L., and Baltimore, D. (1993). Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90, 8392-8396.
41. Poli, G., Bressler, P., Kinter, A., Duh, E., Timmer, W.C., Rabson, A., Justement, J.S., Stanley, S., and Fauci, A.S. (1990a). Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor a by transcriptional and post-transcriptional mechanisms. J. Exp. Med. 172, 151-158.
42. Poli, G., Kinter, A., Justement, J.S., Kehrl, J.H., Bressler, P., Stanley, S., and Fauci, A.S. (1990b). Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc. Natl. Acad. Sci. USA 87, 782-785.
43. Poli, G., Kinter, A.L., Vicenzi, E., and Fauci, A.S. (1994a). Cytokine regulation of acute and chronic HIV infection in vitro: from cell lines to primary mononuclear cells. Res. Immunol. 145, 578-582.
44. Poli, G., Kinter, A.L., and Fauci, A.S. (1994b). Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist. Proc. Natl. Acad. Sci. USA 97, 108-112.
45. Pomerantz, R.J., Feinberg, M.B., Trono, D., and Baltimore, D. (1990). Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J. Exp. Med. 172, 253-261.
46. Roman, C., Platero, J.S., Shuman, J., and Calame, K. (1990). Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev. 4, 1404-1415.
47. Ron, D., Brasier, A., and Habener, J. (1991). Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Mol. Cell. Biol. 11, 2887-2895.
48. Ross, E., Buckler-White, A., Rabson, A., Englund, G., and Martin, M. (1991). Contribution of NF-κB and Sp1 binding motifs to the replicative capacity of HIV-1: distinct patterns of viral growth are determined by T-cell types. J. Virol. 65, 4350-4358.
49. Roulston, A., D'Addario, M., Boulerice, F., Caplan, S., Wainberg, M.A., and Hiscott, J. (1992). Induction of monocytic differentiation and NF-κB-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells. J. Exp. Med. 775, 751-763.
50. Sakaguchi, M., Zenzie-Gregory, B., Groopman, J., Smale, S., and Kim, S. (1991). Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery. J. Virol. 65, 5448-5456.
51. Saksela, K., MucLemore, E., Girard, M., Fultz, P., and Baltimore, D. (1993). High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1 infected chimpanzees. J. Virol. 67, 7423-7427.
52. Scala, G., Ruocco, M.R., Ambrosino, C., Mallardo, M., Giordano, V., Baldassarre, F., Dragonetti, E., Quinto, I., and Venuta, S. (1994). The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein. J. Exp. Med. 179, 961-971.
53. Schnittman, S.M., Psallidopoulos, M.C., Lane, H.C., Thompson, L., Baseler, M., Massari, F., Fox, C.H., Salzman, N.P., and Fauci, A.P. (1989). The reservior for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4. Science 245, 305-308.
54. Screiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1989). Rapid detection of octamer binding proteins with miniextracts prepared from a small number of cells. Nucl. Acid Res. 17, 6419.
55. Southern, P.J., and Berg, P. (1982). Transformation of mammalian cells to antibiotic resistance with bacterial gene under control of the SV40 early region promoter. Mol. Appl. Genet. 1, 327-341.
56. Stein, B., Cogswell, P.C., and Baldwin, A.S. (1993). Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13, 3964-3974.
57. Suzan, M., Salaun, D., Neuveut, C., Spire, B., Hirsch, I., Le Bouteiller, P., Querat, G., and Sire, J. (1991). Induction of NF-KB during monocyte differentiation by HIV type 1 infection. J. Immunol. 146, 377-383.
58. Tesmer, V.M., Rajadhyaksha, A., Babin, J., and Bina, M. (1993). NF-IL-6-mediated transcriptional activation of the long terminal repeat of the human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90, 7298-7302.
59. Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., and Chojkier, M. (1993). Transactivation by NF-IL-6/LAP is enhanced by phosphorylation of its activation domain. Nature 364, 544-547.
60. Trautwein, C., van der Geer, P., Karin, M., Hunter, T., and Chojkier, M. (1994). Protein kinase A and C site-specific phosphorylations of LAP (NF-IL-6) modulate its binding affinity to DNA recognition elements. J. Clin. Invest. 93, 2554-2561.
61. Van Voorhis, W.C., Steinman, L.S., Hair, L.S., Luban, J., Witmer, M.D., Koide, S., and Cohn, Z.A. (1983). Specific antimononuclear phagocyte monoclonal antibodies: application to the purification of dendritic cells and the tissue localization of macrophages. J. Exp. Med. 158, 126-145.
62. Vinson, C., Sigler, P., and McKnight, S. (1989). Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246, 911-916.
63. Wegner, M., Cao, Z., and Rosenfeld, M. (1992). Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256, 370-373.
64. Williams, S., Cantwell, C., and Johnson, P. (1991). A family of C/EBP related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5, 1553-1567.