Acute treatment with the cyclic antidepressant desipramine, but not fluoxetine, increases membrane-associated G protein-coupled receptor kinases 2/3 in rat brain

Neuropharmacology

Volumn 43, Issue 8, 2002, Pages 1249-1257

  Miralles, A ^a   Asensio, V J ^a   Garcia Sevilla J A ^a,b  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

5 HT receptors; Desipramine; Fluoxetine; G protein coupled receptor kinase 2 3; Rat brain; 2 Adrenoceptors

Indexed keywords

ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; DESIPRAMINE; ENZYME ANTIBODY; FLUOXETINE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; ISOENZYME; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DOSE TIME EFFECT RELATION; LONG TERM EXPOSURE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

EID: 0036950710     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00306-4     Document Type: Article

References (47)

1. Arriza J.L., Dawson D.L., Simerly R.B., Martin L.J., Caron M.G., Snyder S.H., Lefkowitz R.J. The G protein-coupled receptor kinase beta ARK1 and beta ARK2 are widely distributed at synapses in the rat brain. Journal of Neuroscience. 12:1992;4045-4055.
2. 1A antagonists. Trends in Neurosciences. 19:1996;378-383.
3. 2-adrenoceptors in the rat brain. Molecular Pharmacology. 42:1992;846-855.
4. Benovic J.L., Onorato J.J., Arriza J.L., Stone W.C., Lohse M., Jenkins N.A., Gilbert D.J., Copeland N.G., Caron M.G., Lefkowitz R.J. Cloning, expression, and chromosomal localization of β-adrenergic receptor kinase 2. Journal of Biological Chemistry. 266:1991;14939-14946.
5. Benovic J.L., Regan J.W., Matsui H., Mayor F. Jr, Cotecchia S., Leeb-lundberg L.M., Caron M.G., Lefkowitz R.J. Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. Journal of Biological Chemistry. 262:1987;17251-17253.
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
7. Charney D.S. Monoamine dysfunction and the pathophysiology and treatment of depression. Journal of Clinical Psychiatry. 59:1998;11-14.
8. Chuang T.T., Iacovelli L., Sallese M., De Blasi A.G. G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends in Pharmacological Sciences. 17:1996;416-421.
9. Delgado P., Moreno F. Antidepressants and the brain. International Clinical Psychopharmacology. 14:(suppl. 1):1999;S9-S16.
10. 2+ channel inhibition. Neuron. 16:1996;579-585.
11. 2A-adrenergic receptor. Journal of Biological Chemistry. 270:1995;4681-4688.
12. Eckhart A.D., Koch W.J. Transgenic studies of cardiac adrenergic receptor regulation. Journal of Pharmacology and Experimental Therapeutics. 299:2001;1-5.
13. Erdtmann-Vourliotis M., Mayer P., Ammon S., Riechert U., Höllt V. Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain. Molecular Brain Research. 95:2001;129-137.
14. 2-adrenoceptor subtypes. Naunyn-Schmiedeberg's Archives of Pharmacology. 353:1996;391-399.
15. 1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology. 360:1999;135-143.
16. Ferguson S.S.G. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacological Reviews. 53:2001;1-24.
17. Fredericks Z.L., Pitcher J.A., Lefkowitz R.J. Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta 2-adrenergic receptor. Journal of Biological Chemistry. 271:1996;13796-13803.
18. Freedman N.J., Liggett S.B., Drachman D.E., Pei G., Caron M.G., Lefkowitz R.J. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Journal of Biological Chemistry. 270:1995;17953-17961.
19. 2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides. Journal of Neurochemistry. 72:1999;282-291.
20. 2-adrenoceptors after inhibition of neuronal uptake by antidepressant drugs in the rat vas deferens. British Journal of Pharmacology. 89:1986;673-683.
21. Gautam N., Downes G.B., Yan K., Kisselev O. The G-protein beta/gamma complex. Cellular Signaling. 10:1998;447-455.
22. Grange-Midroit M., García-Sevilla J.A., Ferrer-Alcón M., La Harpe R., Walzer C., Guimón J. G protein-coupled receptor kinases, β-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution. Molecular Brain Research. 101:2002;39-51.
23. 2A receptor desensitization and resensitization reveal an arrestin-, GRK2- and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Molecular Pharmacology. 60:2001;1020-1030.
24. 2A receptor. Journal of Pharmacology and Experimental Therapeutics. 300:2002;468-477.
25. Harlow E., Lane D. Using Antibodies. A Laboratory Manual. 1999;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
26. Hausdorff W.P., Bouvier M., O'Dowd B.F., Irons G.P., Caron M.G., Lefkowitz R.J. Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. Journal of Biological Chemistry. 264:1989;12657-12665.
27. 1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology. 26:2002;565-573.
28. Hervás I., Queiroz C.M.T., Adell A., Artigas A. Role of uptake inhibition and autoreceptor activation in the control of 5-HT release in the frontal cortex and dorsal hippocampus of the rat. British Journal of Pharmacology. 130:2000;160-166.
29. 2C-Adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation. Journal of Biological Chemistry. 275:2000;28989-28993.
30. Klein U., Müller C., Chu P., Birnbaumer M., Von Zastrow M. Heterologous inhibition of G protein-coupled receptor endocytosis mediated by receptor-specific trafficking of β-arrestins. Journal of Biological Chemistry. 276:2001;17442-17447.
31. Koch W.J., Rockman H.A. Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Trends in Cardiovascular Medicine. 9:1999;77-81.
32. Koch W.J., Rockman H.A., Samana P., Hamilton R.A., Bond R.A., Milano C.A., Lefkowitz R.J. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 268:1995;1350-1353.
33. Krupnick J.G., Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annual Review of Pharmacology and Toxicology. 38:1998;289-319.
34. 2C-adrenergic but not serotonin-1B receptors. Molecular Endocrinology. 13:1999;138-147.
35. Lohse M.J., Krasel C., Winstel R., Mayor F. Jr. G protein-coupled receptor kinases. Kidney International. 49:1996;1047-1052.
36. 2-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. British Journal of Pharmacology. 133:2001;1362-1370.
37. 2-adrenoceptors mediating mydriasis in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 341:1990;101-107.
38. Miralles A., Asensio V.J., García-Sevilla J.A. Efecto de la desipramina sobre la densidad de la cinasa de receptores acoplados a proteínas G (GRK 2) en cerebro de rata. Revista de Neurología. 33:(suppl.):2001;883.
39. Ozaita A., Escribá P.V., Ventayol P., Murga C., Mayor F., García-Sevilla J.A. Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts. Journal of Neurochemistry. 70:1998;1249-1257.
40. Penela P., Ruiz-Gómez A., Castano J.G., Mayor F. Jr. Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. Journal of Biological Chemistry. 273:1998;35238-35244.
41. Pitcher J.A., Freedman N.J., Lefkowitz R.J. G protein-coupled receptor kinases. Annual Review of Biochemistry. 67:1998;653-692.
42. Premont R.T., Macrae A.D., Aparicio S.A.J.R., Kendall H.E., Welch J.E., Lefkowitz R.J. The GRK 4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization and sequence conservation. Journal of Biological Chemistry. 274:1999;29381-29389.
43. 2-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA. British Journal of Pharmacology. 132:2001;1467-1476.
44. 7 receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. British Journal of Pharmacology. 132:2001;1574-1580.
45. Rockman H.A., Choi D.-J., Akhter S.A., Jaber M., Giros B., Lefkowitz R.J., Caron M.G., Koch W.J. Control of myocardial contractile function by the level of β-adrenergic receptor kinase 1 in gene-targeted mice. Journal of Biological Chemistry. 273:1998;18180-18184.
46. Sastre-Coll A., Esteban S., García-Sevilla J.A. Effects of imidazoline receptor ligands on monoamine synthesis in the rat brain in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology. 360:1999;50-62.
47. Wess J. Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology. Trends in Pharmacological Sciences. 21:2000;364-366.