Atherosclerotic expansive remodeled plaques: A wolf in sheep's clothing

Journal of Vascular Research

Volumn 39, Issue 6, 2002, Pages 514-523

  Pasterkamp, Gerard ^a   Fitzgerald, Peter F ^b   De Kleijn, Dominique P V ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angina; Arterial remodeling; Atherosclerosis; Cardiovascular diseases; Constrictive remodeling; Plaque rupture

Indexed keywords

ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE PREDISPOSITION; FEASIBILITY STUDY; FOLLOW UP; GEOMETRY; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REGULATORY MECHANISM; RUPTURE; TIME; TISSUE REPAIR;

CORONARY ARTERIOSCLEROSIS; CORONARY CIRCULATION; HUMANS; VENTRICULAR REMODELING;

EID: 0036948315     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067204     Document Type: Article

References (68)

1. Armstrong ML, Heistad DD, Marcus ML, Megan MB, Piegors DJ: Structural and hemodynamic responses of peripheral arteries of macaque monkeys to atherogenic diet. Arteriosclerosis 1985;5:336-346.
2. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis G: Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371-1375.
3. Hermiller JB, Tenaglia AN, Kisslo KB, Phillips HR, Bashore TM, Stack RS, Davidson CJ: In vivo validation of compensatory enlargement of atherosclerotic coronary arteries. Am J Cardiol 1993;71:665-668.
4. Alfonso F, Macaya C, Goicolea J, Iniguez A, Hernandez R, Zamorano J, Perez-Vizcayne MJ, Zarco P: Intravascular ultrasound imaging of angiographically normal coronary segments in patients with coronary artery disease. Am Heart J 1994;127:536-544.
5. Pasterkamp G, Wensing PJW, Post MJ, Hillen B, Mali WPTM, Borst C: Paradoxical arterial wall shrinkage contributes to luminal narrowing of human atherosclerotic femoral arteries. Circulation 1995;91:1444-1449.
6. Pasterkamp G, Borst C, Post MJ, Mali WPTM, Wensing PJW, Gussenhoven EJ, Hillen B: Atherosclerotic arterial remodeling in the superficial femoral artery: Individual variation in local compensatory enlargement response. Circulation 1996;93:1818-1825.
7. Nishioka T, Luo H, Eigler NL, Berglund H, Kim CJ, Siegel RJ: Contribution of inadequate compensatory enlargement to development of human coronary artery stenosis: An in vivo intravascular ultrasound study. J Am Coll Cardiol 1996;27:1571-1576.
8. Mintz GS, Kent KM, Pichard AD, Satler LF, Popma JJ, Leon MB: Contribution of inadequate arterial remodeling to the development of focal coronary artery stenoses: An intravascular ultrasound study. Circulation 1997;95:1791-1798.
9. Pasterkamp G, de Kleijn DPV, Borst C: Arterial remodeling in atherosclerosis, restenosis and after alteration in blood flow: Potential mechanisms and clinical implications. Cardiovasc Res 2000;45:843-852.
10. Ward MJ, Pasterkamp G, Yeung AC, Borst C: Clinical implications of arterial remodeling. Circulation 2000;102:1186-1191.
11. Vink A, Schoneveld AH, Richard W, de Kleijn DPV, Falk E, Borst C, Pasterkamp G: Plaque burden, arterial remodeling and plaque vulnerability: Determined by systemic factors? J Am Coll Cardiol 2001;38:718-723.
12. Pasterkamp G, Schoneveld AH, van Wolferen WA, Hillen B, Clarijs RJG, Haudenschild CC, Borst C: The impact of atherosclerotic arterial remodeling on percentage luminal stenosis varies widely within the arterial system: A post mortem study. Arterioscler Thromb Vasc Biol 1997;17:3057-3063.
13. Pasterkamp G, Jeremias A, Vink A, Yeung AC, Smits PC, Fitzgerald P, Borst C: The relative contributions of constrictive remodeling and plaque mass to atherosclerotic luminal narrowing: An intravascular ultrasound study. Eur Heart J 2000;21:506.
14. Smits PC, Pasterkamp G, de Jaegere PJ, Eefting FD, Stella PR, Borst C: Coronary artery disease: Arterial remodeling and clinical presentation. Heart 1999;82:461-464.
15. Wexberg P, Gyongyoshi M, Sperker W, Kiss K, Yang P, Hassan A, Pasterkamp G, Glogar D: Pre-existing arterial remodeling is associated with in-hospital and late adverse cardiac events after coronary interventions in patients with stable angina pectoris. J Am Coll Cardiol 2000;36:1860-1869.
16. Dangas G, Mintz GS, Mehran R, Lansky AJ, Kornowski R, Pichard AD, Satler LF, Kent KM, Stone GW, Leon MB: Preintervention arterial remodeling as an independent predictor of target lesion revascularization after non stent coronary intervention. Circulation 1999;99:3149-3154.
17. Nakamura M, Nishikawa H, Mukai S, Setsuda M, Nakajima K, Tamada H, Suzuki H, Ohnishi T, Kakuta Y, Nakano T, Yeung AC: Impact of coronary artery remodeling on clinical presentation of coronary artery disease: An intravascular ultrasound study. J Am Coll Cardiol 2001;37:63-69.
18. Okura H, Morino Y, Oshima A, Hayase M, Ward MR, Popma JJ, Kuntz RE, Bonneau HN, Yock PG, Fitzgerald PJ: Preintervention arterial remodeling affects clinical outcome following stenting: An intravascular ultrasound study. J Am Coll Cardiol 2001;37:1031-1035.
19. von Birgelen C, Klinkhart W, Mintz GS, Papatheodorou A, Herrman J, Baumgart D, Haude M, Wieneke H, Ge J, Erbel R: Plaque distribution and vascular remodeling of ruptured and nonruptured plaques in the same vessel: An intravascular ultrasound study in vivo. J Am Coll Cardiol 2001;37:1864-1870.
20. Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu M: Extent and direction of arterial remodeling in stable versus unstable coronary syndromes. Circulation 1999;101:598-603.
21. Davies MJ, Thomas AC: Plaque fissuring - The cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 1985;53:363-373.
22. Fuster V, Badimon L, Badimon J, Chesebro JH: The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:242-250, 310-318.
23. Fuster V, Lewis A: Conner Memorial Lecture: Mechanisms leading to myocardial infarction: Insights from studies of vascular biology. Circulation 1994;90:2126-2146.
24. van der Wal AC, Becker AE, van der Loos CM, Das PK: Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994;89:36-44.
25. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT: Macrophage infiltration in acute coronary syndromes: Implications for plaque rupture. Circulation 1994;90:775-778.
26. Falk E, Shah PK, Fuster V: Coronary plaque disruption. Circulation 1995;92:657-671.
27. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J: Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J 1993;69:377-381.
28. Ambrose JA, Tannenbaum, Alexopoulos D, et al: Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988;12:56-62.
29. Little WC, Constantinescu M, Applegate RJ, et al: Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 1988;78:1157-1166.
30. Alderman EL, Corley SD, Fisher LD, et al: Five year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 1993;22:1141-1154.
31. Mann JM, Davies MJ: Vulnerable plaque. Relation of characteristics to degree of stenosis in human coronary arteries. Circulation 1996;94:928-931.
32. Pasterkamp G, Schoneveld AH, van der Wal AC, Haudenschild CC, Clarijs RJG, Becker AE, Hillen B, Borst C: The relation of arterial geometry with luminal narrowing and plaque vulnerability: The remodeling paradox. J Am Coll Cardiol 1998;32:655-662.
33. Pasterkamp G, Schoneveld AH, Hijnen DJ, de Kleijn DPV, Teepen H, van der Wall AC, Borst C: Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteinases in the human coronary artery. Atherosclerosis 2000;150:245-253.
34. Burke AP, Kolodgie FD, Farb A, Weber D, Virmani R: Morphological predictors of arterial remodeling in coronary atherosclerosis. Circulation 2002;105:297-303.
35. Varnava AM, Mills PG, Davies MJ: Relationship between coronary artery remodeling and plaque vulnerability. Circulation 2002;105:939-943.
36. de Korte CL, Pasterkamp G, van der Steen AFW, Woutman HA, Bom N: Characterization of plaque components with intravascular ultrasound elastography: A validation study in vitro. Circulation 2000;102:617-623.
37. Stefanadis C, Diamantopoulos L, Vlachopoulos C, Tsiamis E, Dernellis J, Toutouzas K, Stefanadi E, Toutouzas P: Thermal heterogeneity within human atherosclerotic coronary arteries detected in vivo. Circulation 1999;99:1965-1971.
38. Thieme T, Wernecke KD, Meyer R, Brandenstein E, Habedank D, Hinz A, Felix SB, Baumann G, Kleber FX, et al: Angioscopic evaluation of atherosclerotic plaques. Validation by histomorphologic analysis and association with stable and unstable coronary syndromes. J Am Coll Cardiol 1996;28:1-6.
39. Smits PC, Pasterkamp G, de Jaegere PPT, de Feyter PJ, Borst C: Angioscopic complex lesions are predominantly compensatory enlarged: An angioscopy and intracoronary ultrasound study. Cardiovasc Res 1999;41:458-464.
40. Gyongyosi M, Yang P, Hassan A, Domanovits H, Laggner A, Weidinger F, Glogar D: Intravascular ultrasound predictors of major adverse cardiac events in patients with unstable angina. Clin Cardiol 2000;23:507-515.
41. Mintz GS, Kimura T, Nobuyoshi M, Dangas G, Leon MB: Relation between preintervention remodeling and late arterial responses to coronary angioplasty or atherectomy. Am J Cardiol 2001;87:392-396.
42. Libby P: Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001;104:365-372.
43. Moore M, Shixiong L, Curci JA, Starcher BC, Martin RL, Hendricks RT, Chen JJ, Thompson RW: Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). J Vasc Surg 1999;29:522-532.
44. Bigatel DA, Elmore JR, Carey DJ, Cizmeci-Smith G, Franklin DP, Youkey JR: The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. J Vasc Surg 1999;29:130-139.
45. Karwowski JK, Markezich A, Whitson J, Abbruzzese TA, Zarins CK, Dalman RL: Dose-dependent limitation of arterial enlargement by the matrix metalloproteinase inhibitor RS-113,456. J Surg Res 1999;87:122-129.
46. Sierevogel MJ, Pasterkamp G, Velema E, De Kleijn DPV, De Smet BJGL, De Jaegere PPT, Borst C: Oral matrix metalloproteinase inhibition blocks constrictive arterial remodeling following balloon dilation in the pig. Circulation 2001;103:302-307.
47. Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC: Production and localization of 92 kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest 1995;96:318-326.
48. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA: Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 1999;104:1191-1197.
49. Prescott MF, Sawyer WK, Von Linden-Reed J, Jeune M, Chou M, Caplan SL, Jeng AY: Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12 and MMP-13 and on restenosis in rats after balloon injury. Ann NY Acad Sci 1999;878:179-190.
50. Anidjar S, Salzmann JL, Gentric D, Lagneau P, Camilleri JP, Michel JB: Elastase induced experimental aneurysms in rats. Circulation 1990;82:973-981.
51. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P: Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998;102:576-583.
52. Walsh K, Smith RC, Kim HS: Vascular cell apoptosis in remodeling, restenosis and plaque rupture. Circ Res 2000;87:184-188.
53. Bennett MR, Evan GI, Schwartz SM: Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 1995;95:2266-2274.
54. Bennett MR, Littlewood TD, Schwartz SM, Weissberg PL: Increased sensitivity of human vascular smooth muscle cells from atherosclerotic plaques to p53-mediated apoptosis. Circ Res 1997;81:591-599.
55. Boyle JJ, Bowyer DE, Weissberg PL, Bennett MR: Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth cells by Fas-ligand/Fas interactions. Arterioscler Thromb Vasc Biol 2001;21:1402-1407.
56. Jacob T, Ascher E, Hingorani A, Gunduz Y, Kallakuri S: Initial steps in the unifying theory of the pathogenesis of aortic aneurysms. J Surg Res 2001;101:37-43.
57. Hassan AH, Lang IM, Ignatescu M, Ullrich R, Bonderman D, Wexberg P, Weidinger F, Glogar HD: Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargement. J Am Coll Cardiol 2001;38:1333-1339.
58. De Kleijn DPV, Sluijter JPG, Smit J, Velema E, Schoneveld AH, Pasterkamp G, Borst C: Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling. FEBS Lett 2001;501:37-41.
59. Langille BL: Arterial remodeling: Relation to hemodynamics. Can J Physiol Pharmacol 1996;74:834-841.
60. Langille BL, O'Donnell F: Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science 1986;231:405-407.
61. Tronc F, Wassef M, Esposito B, Henrion D, Glagov S, Tedgui A: Role of NO in flow-induced remodeling of the rabbit common carotid artery. Arterioscler Thromb Vasc Biol 1996;16:1256-1262.
62. Guzman RJ, Abe K, Zarins CK: Flow-induced arterial enlargement is inhibited by suppression of nitric oxide synthase activity in vivo. Surgery 1997;122:273-280.
63. Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC: Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998;101:731-736.
64. De Smet BJGL, De Kleijn DPV, Hanemaaijer H, Verheijen H, Robertus JL, van der Helm YJM, Borst C, Post MJ: Metalloproteinase inhibition reduces constrictive arterial remodeling following balloon angioplasty: A study in the atherosclerotic Yucatan micropig. Circulation 2000;101:2962-2967.
65. Fuster V, Badimon J, Chesebro JH, Fallon JT: Plaque rupture, thrombosis, and therapeutic implications. Haemostasis 1996;26(suppl 4):269-284.
66. Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M: Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits. Circulation 2001;103:993-999.
67. Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001;7:687-692.
68. Pasterkamp G, Schoneveld AH, van der Wal AC, Hijnen DJ, van Wolveren WJA, Plomp S, Teepen HLJM, Borst C: Inflammation of the atherosclerotic cap and shoulder of the plaque is a common and locally observed feature in unruptured plaques of femoral and coronary arteries. Arterioscler Thromb Vasc Biol 1999;19:54-58.