Histone H2AX in DNA repair

Nukleonika

Volumn 47, Issue 4, 2002, Pages 127-131

  Lewandowska, Hanna ^a   Szumiel, Irena ^a  

^a INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

Author keywords

DNA double strand breaks; DNA repair; Histone H2AX; Ionising radiation

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; HISTONE H2A;

ARTICLE; CELL NUCLEUS; CELLULAR IMMUNITY; CHROMATIN; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; IONIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RADIATION; SIGNAL TRANSDUCTION;

EID: 0036938596     PISSN: 00295922     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G (2001) Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 276:38224-38230
2. Badie C, Iliakis G, Foray N et al. (1995) Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines. Radiat Res 144:26-35
3. Brownell JE, Zhou J, Ranalli T et al. (1996) Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843-851
4. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276:42462-42467
5. Carbone R, Pearson M, Minucci S, Pelicci PG (2002) PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. Oncogene 21:1633-1640
6. Chen HT, Bhandoola A, Difilippantonio MJ et al. (2000) Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science 29:1962-1965
7. Costanzo V, Robertson K, Bibikova M et al. (2001) Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell 8:137-147
8. Downs JA, Lowndes NF, Jackson SP (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408:1001-1004
9. Gately DP, Hittle JC, Chan GK, Yen TJ (1998) Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol Biol Cell 9:2361-2374
10. Hoppe BS, Jensen RB, Kirchgessner CU (2000) Complementation of the radiosensitive M059J cell line. Radiat Res 153:125-130
11. Maser RS, Monsen KJ, Nelms BE, Petrini JH (1997) hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 17:6087-6096
12. O'Neill LP, Turner BM (1995) Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. EMBO J 14:3946-3957
13. Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886-895
14. Petersen S, Casellas R, Reina-San-Martin B et al. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414:660-665
15. Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W (2002) Histone H2A variants H2AX and H2AZ. Curr Opin Genet Dev 12:162-169
16. Rogakou EP, Boon C, Redon C, Bonner WM (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905-916
17. Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM (2000) Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275:9390-9395
18. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273:5858-5868
19. Szumiel I (1998) Monitoring and signalling of radiation-induced damage in mammalian cells. Radiat Res 150;S1:s92-s101