Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-α through ceramide pathway

Cellular Immunology

Volumn 219, Issue 1, 2002, Pages 1-10

  Mangalam, Ashutosh Kumar ^a   Aggarwal, Amita ^a   Naik, Sita ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Ceramide; Cytokines; Human; Inflammation; Lipopolysaccharide; RT PCR and transcription factors

Indexed keywords

AUROTHIOMALATE; BACTERIUM LIPOPOLYSACCHARIDE; CERAMIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HUMAN; HUMAN CELL; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; ANTIRHEUMATIC AGENTS; CELLS, CULTURED; CERAMIDES; FEMALE; GOLD SODIUM THIOMALATE; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 0036926171     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-8749(02)00580-4     Document Type: Article

References (59)

1. R.L. Ulevtich, P.S. Tobias, Receptor-dependents mechanisms of cell stimulation by bacterial endotoxin, Annu. Rev. Immunol. 13 (1995) 437-459.
2. E. Hailman, T. Vasselon, M. Kelley, L.A. Busse, M.C. Hu, H.S. Lichenstein, P.A. Detmers, S.D. Wright, Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14, J. Immunol. 156 (1996) 4384-4390.
3. R.B. Yang, M.R. Mark, A. Gray, A. Huang, M.H. Xie, M. Zhang, A. Goddard, W.I. Wood, A.L. Gurney, P.J. Godowski, Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling, Nature 395 (1998) 284-288.
4. B. Beutler, Tlr4: Central component of the sole mammalian LPS sensor, Curr. Opin. Immunol. 12 (2000) 20-26.
5. S.L. Weinstein, J.S. Sanghera, K. Lemke, A.L. DeFranco, S.L. Pelech, Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages, J. Biol. Chem. 267 (1992) 14955-14962.
6. J.S. Sanghera, S.L. Wemstein, M. Aluwalia, J. Girn, S.L. Pelech, Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages, J. Immunol. 156 (1996) 4457-4465.
7. J. Han, J.-D. Lee, L. Bibbs, R.J. Ulevitch, A MAP kinase targeted by endotoxin and hypoosmolarity in mammalian cells, Science 265 (1994) 808-811.
8. L. Shapira, S. Takashiba, C. Champagne, S. Amar, T.E. van Dyke, Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-α arid IL-1β production by human monocytes, J. Immunol. 153 (1994) 1818-1824.
9. J.P. Jakway, A.L. DeFranco, Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide, Science 234 (1986) 743-746.
10. I. Stefanova, M.L. Corcoran, E.M. Horak, L.M. Wahl, J.B. Bolen, I.D. Horak, Lipopolysaccharide-induced activation of CD-14-associated protein tyrosine kinase p53/56lyn, J. Biol. Chem. 268 (1993) 20725-20728.
11. P.J. Barnes, M. Karin, Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory disease, N. Engl. J. Med. 336 (1997) 1066-1071.
12. J.S. Downey, J. Han, Cellular activation mechanism in septic shock, Front. Biosci. 3 (1998) 468-476.
13. R. Kolesnick, D.W. Golde, The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling, Cell 77 (1994) 325-328.
14. C.K. Joseph, S.D. Wright, W.G. Bornmann, J.T. Randolph, E.R. Kumar, R. Bittman, J. Liu, R.N. Kolesnick, Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase (CAPK) in myeloid cells, J. Biol. Chem. 269 (1994) 17606-17610.
15. R.T. Dobrowsky, Y.A. Hannun, Ceramide stimulates a cytosolic protein phosphatase, J. Biol. Chem. 267 (1992) 5048-5051.
16. B. Yao, Y. Zhang, S. Delicat, S. Mathias, S. Basu, R.N. Kolesnick, Phosphorylation of raf by ceramide activated protein kinase, Nature 378 (1995) 307-310.
17. S.D. Wright, R.N. Kolesnick, Does endotoxin stimulate cells by mimicking ceramide?, Immunol. Today 16 (1995) 297-302.
18. d) macrophages, J. Immunol. 155 (1995) 2303-2305.
19. S.A. Barber, G. Detore, R. McNally, S.N. Vogel, Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages, Infect. Immun. 64 (1996) 3397-4000.
20. G. Buchan, K. Barrett, M. Turner, D. Chantry, R.N. Maini, M. Fieldmann, Interleukin-1 and tumor necrosis factor mRNA expression in rheumatoid arthritis: Prolonged production of IL-1α, Clin. Exp. Immunol. 73 (1988) 449-455.
21. F.M. Brennan, R.N. Maini, M. Feldmann, Role of pro-inflammatory cytokines in rheumatoid arthritis, Springer. Semin. Immunopathol. 20 (1998) 133-147.
22. R.O. Williams, M. Feldmann, R.N. Maini, Anti-TNF ameliorates joint disease in murine collagen-induced arthritis, Proc. Natl. Acad. Sci. USA 89 (1992) 9784-9788.
23. P.H. Wooley, J. Dutcher, M.B. Widmer, S. Gillis, Influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice, J. Immunol. 151 (1993) 6602-6607.
24. M.J. Elliott, R.N. Maini, M. Feldmann, A. Long-Fox, P. Charles, P. Katsikis, F.M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, J.N. Woody, Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α, Arthritis. Rheum. 36 (1993) 1681-1690.
25. M.J. Elliott, R.N. Maini, M. Feldmann, A. Long-Fox, P. Charles, H. Bijl, J.N. Woody, Repeated therapy with monoclonal antibodies to tumor necrosis factor α (cA2) in patients with rheumatoid arthritis, Lancet 344 (1994) 1125-1127.
26. P. Charles, M.J. Elliott, D. Davis, A. Potter, J.R. Kalden, C. Antoni, F.C. Breedveld, J.S. Smolen, G. Eberl, K. deWoody, M. Feldmann, R.N. Maini, Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-α therapy in rheumatoid arthritis, J. Immunol. 163 (1999) 1521-1528.
27. V.A. Danis, A.J. Kulesz, D.S. Nelson, P.M. Brooks, The effect of gold sodium thiomalate and auranofin on lipopolysaccharide-induced Interleukin-1 production by blood monocytes in vitro: Variation in healthy subjects and patients with arthritis, Clin. Exp. Rheumatol. 79 (1990) 335-340.
28. G. Yanni, M. Nabil, M.R. Farahat, R.N. Poston, G.S. Panayi, Intramuscular gold decreases cytokine expression and macrophage numbers in the synovial membrane, Ann. Rheum. Dis. 53 (1994) 315-322.
29. M. Seitz, P. Loetscher, B. Dewald, H. Towbin, M. Baggiolini, In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs, J. Rheumatol. 24 (1997) 1471-1476.
30. R. Yadav, R. Misra, S. Naik, In vitro effect of gold sodium thiomalate and methotrexate on tumor necrosis factor production in normal healthy individuals and patients with rheumatoid arthritis, Int. J. Immunopharmacol. 19 (1997) 111-114.
31. A.K. Mangalam, A. Aggarwal, S. Naik, Mechanism of action of disease modifying anti-rheumatic agent, gold sodium thiomalate (GSTM), Int. Immunopharmacol. 1 (6) (2001) 1165-1172.
32. A. Boyum, Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g, Scand. J. Clin. Lab. Invest. Suppl. 97 (1968) 77-89.
33. S.R. Cordle, R. Donald, M.A. Read, J. Hawiger, Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1 cells, J. Biol. Chem. 268 (1993) 11803-11810.
34. E. Schreiber, P. Matthias, M.M. Muller, W. Schaffner, Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells, Nucleic Acids Res. 17 (1989) 6419.
35. M. Bradford, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
36. H.H. Hassanain, W. Dai, S.L. Gupta, Enhanced gel mobility shift assay for DNA-binding factors, Anal. Biochem. 213 (1993) 162-167.
37. H. Singh, J.H. Lebowitz, A.S. Baldwin Jr., P.A. Sharp, Molecular cloning of an enhancer binding protein: Isolation by screening of an expression library with a recognition site DNA, Cell 52 (1988) 415-423.
38. Y.A. Hannun, The sphingomyelin cycle and the second messenger function of ceramide, J. Biol. Chem. 269 (1994) 3125-3128.
39. P. Morell, P. Braun, Biosynthesis and metabolic degradation of sphingolipids net containing sialic acid, J. Lipid Res. 13 (1992) 293-310.
40. S.J. Laulederkind, A. Bielawska, R. Raghow, Y.A. Hannun, L.R. Ballou, Ceramide induces interleukin 6 gene expression in human, J. Exp. Med. 182 (1995) 599-604.
41. K.M. Knapp, B.K. English, Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity, J. Leukoc. Biol. 67 (2000) 735-741.
42. E. Coroneos, Y. Wang, J.R. Panuska, D.J. Templeton, M. Kester, Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades, Biochem. J. 316 (1996) 13-17.
43. C.J. Lo, M. Fu, F.R. Lo, H.G. Cryer, Macrophage TNF mRNA expression induced by LPS is regulated by sphingomyelin metabolites, Shock 11 (1999) 411-415.
44. K. Nakajima, Y. Tohyama, S. Kohsaka, T. Kurihara, Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro, J. Neurochem. 80 (2002) 697-705.
45. Y.W. Hsu, K.H. Chi, W.C. Huang, W.W. Lin, Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: Effects on protein kinases and transcription factors, J. Immunol. 166 (2001) 5388-5397.
46. G. Lochnit, R.D. Dennis, A.J. Ulmer, R. Geyer, Structural elucidation and monokine-inducing activity of two biologically active zwitterionic glycosphingolipids derived from the porcine parasitic nematode Ascaris suum, J. Biol. Chem. 273 (1998) 466-474.
47. J. Bondeson, R. Sundler, Auranofin inhibits the induction of interleukin 1β and tumor necrosis factor α mRNA in macrophages, Biochem. Pharmacol. 50 (1995) 1753-1759.
48. W. Schraut, P. Wendelgass, J.C. Calzada-Wack, M. Frankenberger, H.W. Ziegler-Heitbrock, TNF gene expression in monocytes of low and high responder individuals, Cytokine 9 (1997) 206-211.
49. M.L. Handel, L.B. McMorrow, E.M. Gravallese, Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65, Arthritis Rheum. 38 (1995) 1762-1770.
50. R. Marok, P.G. Winyard, A. Coumbe, M.L. Kus, K. Gaffney, S. Blades, P.I. Mapp, C.J. Morris, D.R. Blake, C. Kaltschmidt, P.A. Baeuerle, Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue, Arthritis Rheum. 39 (1996) 583-591.
51. C. Wahl, S. Liptay, G. Adler, R.M. Schmid, Sulfasalazine: A potent and specific inhibitor of nuclear factor κB, J. Clin. Invest. 101 (1998) 1163-1174.
52. S.K. Manna, B.B. Aggarwal, α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents, J. Immunol. 161 (1998) 2873-2880.
53. K.I. Jeon, J.Y. Jeong, D.M. Jue, Thiol-reactive metal compounds inhibit NF-κB activation by blocking IκB kinase, J. Immunol. 164 (2000) 5981-5989.
54. B. Foxwell, K. Browne, J. Bondeson, C. Clarke, R. de Martin, F. Brennan, M. Feldmann, EUcient adenoviral infection with IκB α reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent, Proc. Natl. Acad. Sci. USA 95 (1998) 8211-8215.
55. A.V. Miagkov, D.V. Kovalenko, C.E. Brown, J.R. Didsbury, J.P. Cogswell, S.A. Stimpson, A.S. Baldwin, S.S. Makarov, NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint, Proc. Natl. Acad. Sci. USA 95 (1998) 13859-13864.
56. J. Lozano, E. Berra, M.M. Municio, M.T. Diaz-Meco, I. Dominguez, L. Sanz, J. Moscat, Protein kinase C zeta isoform is critical for κB-dependent promoter activation by sphingomyelinase, J. Biol. Chem. 269 (1994) 19200-19207.
57. B. Yao, Y. Zhang, S. Delikat, S. Mathias, S. Basu, R. Kolesnick, Phosphorylation of Raf by ceramide-activated protein kinase, Nature 378 (1995) 307-310.
58. K.J. Procyk, M.R. Rippo, R. Testi, F. Hoffmann, P.J. Parker, M. Baccarini, Lipolysaccharide induces Jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C ζ and phosphoatidylcholine-dependent phospholipase C, Blood 96 (2000) 2592-2598.
59. E. Kopp, S. Ghosh, Inhibition of NF-κB by sodium salicylate and aspirin, Science 265 (1994) 956-959.