A γ-herpesvirus immune evasion gene allow tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope

European Journal of Immunology

Volumn 32, Issue 12, 2002, Pages 3481-3487

  Rice, Jason ^a   de Lima, Brigitte ^b   Stevenson, Freda K ^a   Stevenson, Philip G ^b  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Chemokine; Chemotaxis; Tumor immunity; Vaccination

Indexed keywords

BINDING PROTEIN; CHEMOKINE; CHEMOKINE BINDING PROTEIN; CHEMOKINE RECEPTOR; DNA VACCINE; EPITOPE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG TARGETING; GENETIC TRANSDUCTION; HERPES VIRUS; IN VIVO STUDY; LYMPHOCYTE MIGRATION; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SUBCUTANEOUS TISSUE TUMOR; TUMOR CELL; TUMOR IMMUNITY; VIRAL GENETICS;

ANIMALS; ANTIGENS, NEOPLASM; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; GAMMAHERPESVIRINAE; GENES, VIRAL; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED; VACCINES, DNA; VIRAL PROTEINS;

EID: 0036918638     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200212)32:12<3481::AID-IMMU3481>3.0.CO;2-J     Document Type: Article

References (26)

1. Rickinson, A. B. and Kieff, E., Epstein-Barr virus. In Fields, B. N., Knipe, D. M. and Howley, P. M. (Eds.) Field's Virology. Lippincott-Raven, Philadelphia 1996, pp 2397.
2. Ensoli, B. and Sirianni, M. C., Kaposi's sarcoma pathogenesis: a link between immunology and tumour biology. Crit. Rev. Oncog. 1998. 9: 107-124.
3. Kretschmer, C., Murphy, C., Biesinger, B., Beckers, J., Fickenscher, H., Kirchner, T., Fleckenstein, B. and Ruther, U., A herpes saimiri oncogene causing peripheral T cell lymphoma in transgenic mice. Oncogene 1996. 12: 1609-1616.
4. Nash, A. A., Dutia, B. M., Stewart, J. P. and Davison, A. J., Natural history of murine gamma-herpesvirus infection. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2001. 356: 569-579.
5. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., Cohen, J. I. and Spriggs, M. K., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995. 3: 811-821.
6. Hsu, D. H., de Waal Malefyt, R., Florentino, D. F., Dang, M. N., Vieira, P., de Vries, J., Spits, H., Mosmann, T. R. and Moore, K. W., Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 1990. 250: 830-832.
7. Strockbine, L. D., Cohen, J. I., Farrah, T., Lyman, S. D., Wagener, F., DuBose, R. F., Armitage, R. J. and Spriggs, M. K., The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor. J. Virol. 1998. 72: 4015-4021.
8. Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S. and Reitz, M. S., Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat. Med. 1997. 3: 287-292.
9. Rosenkilde, M. M., Waldhoer, M., Luttichau, H. R. and Schwartz, T. W., Virally encoded 7TM receptors. Oncogene 2001. 20: 1582-1593.
10. Parry, C. M., Simas, J. P., Smith, V. P., Stewart, C. A., Minson, A. C., Efstathiou, S. and Alcami, A. A., A broad-spectrum secreted chemokine-binding protein encoded by a herpesvirus. J. Exp. Med. 2000. 191: 573-578.
11. van Berkel, V., Barrett, J., Tiffany, H. L., Fremont, D. H., Murphy, P. M., McFadden, G., Speck, S. H. and Virgin, H. W. IV. Identification of a gammaherpesvirus-selective chemokine-binding protein that inhibits chemokine action. J. Virol. 2000. 74: 6741-6747.
12. Sallusto, F., Mackay, C. R. and Lanzavecchia, A., The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 2000. 18: 593-620.
13. Bridgeman, A., Stevenson, P. G., Simas, J. P. and Efstathiou, S., A secreted chemokine-binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load. J. Exp. Med. 2001. 194: 301-312.
14. + T lymphocytes. Proc. Natl. Acad. Sci. USA 1999. 96: 7508-7513.
15. Boname, J. M. and Stevenson, P. G., MHC class I ubiquitination by a viral PHD/LAP finger protein. Immunity 2001. 15: 627-636.
16. Simas, J. P., Swann, D., Bowden, R. and Efstathiou, S., Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection. J. Gen. Virol. 1999. 80: 75-82.
17. Rochford, R., Lutzke, M. L., Alfinito, R. S., Clavo, A. and Cardin, R. D., Kinetics of murine gammaherpesvirus 68 gene expression following infection of murine cells in culture and in mice. J. Virol. 2001. 75: 4955-4963.
18. Gorelik, L. and Flavell, R. A., Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signalling in T cells. Nat. Med. 2001. 7: 1118-1122.
19. Mukherji, B., Chakraborty, N. G., Yamasaki, S., Okino, T., Yamase, H., Sporn, J. R., Kurtzman, S. K., Ergin, M. T., Ozols, J., Meehan, J. and Mauri, F., Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen-presenting cells. Proc. Natl. Acad. Sci. USA 1995. 92: 8078-8082.
20. Perez-Diez, A., Spiess, P. J., Restifo, N. P., Matzinger, P. and Marincola, F. M., Intensity of the vaccine-elicited immune response determines tumor clearance. J. Immunol. 2002. 168: 338-347.
21. Rice, J., Elliott, T., Buchan, S. and Stevenson, F. K., DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: implications for cancer vaccines. J. Immunol. 2001. 167: 1558-1565.
22. van Berkel, V., Preiter, K., Virgin, H. W. and Speck, S. H., Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein. J. Virol. 1999. 73: 4524-4529.
23. Karre, K., Ljunggren, H. G., Piontek, G. and Kiessling, R., Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 1986. 319: 675-678.
24. van Hall, T., van Bergen, J., van Veelen, P. A., Kraakman, M., Heukamp, L. C., Koning, F., Meilef, C. J., Ossendorp, F. and Offringa, R., Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin. J. Immunol. 2000. 165: 869-877.
25. + T cells. J. Fxp. Med. 2001. 194: 953-966.
26. Stevenson, P. G., Efstathiou, S., Doherty, P. C. and Lehner, P. J., Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc. Natl. Acad. Sci. USA 2000, 97: 8455-8460.