A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load

Journal of Experimental Medicine

Volumn 194, Issue 3, 2001, Pages 301-312

  Bridgeman, A ^a   Stevenson, P G ^a   Simas, J P ^a   Efstathiou, S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD8+ T lymphocyte; Herpesvirus; Immune evasion; Latency; Pathogenesis

Indexed keywords

BINDING PROTEIN; CD8 ANTIGEN; CHEMOKINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HERPES VIRUS; HERPES VIRUS 68; HUMAN HERPESVIRUS 8; INFECTIOUS MONONUCLEOSIS; LATENT PERIOD; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; FEMALE; GAMMAHERPESVIRINAE; GENE TARGETING; HERPESVIRIDAE INFECTIONS; IN SITU HYBRIDIZATION; MICE; MICE, INBRED BALB C; MUTATION; RNA, TRANSFER; RNA, VIRAL; SPLEEN; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0035817385     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.3.301     Document Type: Article

References (49)

1. Chemokines and leukocyte traffic
2. Chemokines
3. Viral mechanisms of immune evasion
4. Modulating chemokines: More lessons from viruses
5. Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus
6. Immunomodulation by viruses: The myxoma virus story
7. A broad spectrum secreted chemokine binding protein encoded by a herpesvirus
8. Vaccinia virus immune evasion
9. Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action
10. Adoption of chemokine elements by herpesviruses
11. RANTES binding and down-regulation by a novel human herpesvirus-6 beta chemokine receptor
12. The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues
13. Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein M-T1, during myxoma virus pathogenesis
14. Mapping and investigation of the role in pathogenesis of the major unique secreted 35-kDa protein of rabbitpox virus
15. Isolation of five strains of herpesviruses from two species of free living small rodents
16. Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri
17. Murine gammaherpesvirus-68; a model for the study of gammaherpesvirus pathogenesis
18. Complete sequence and genomic analysis of murine gammaherpesvirus 68
19. Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency
20. Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency
21. Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus-68 are dispensable for lytic replication in vitro and latency in vivo
22. The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency
23. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma
24. Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells
25. Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice
26. + T cells
27. B cells regulate murine gammaherpesvirus 68 latency
28. Latent murine γ-herpesvirus infection is established in activated B cells, dendritic cells and macrophages
29. Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo
30. Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice
31. Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells
32. Murine Gammaherpesvirus-68 encodes tRNA-like sequences which are expressed during latency
33. Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection
34. Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus
35. Non-antigen-specific B-cell activation following murine gammaherpesvirus infection is CD4 independent in vitro but CD4 dependent in vivo
36. Tuning into immunological dissonance: An experimental model for infectious mononucleosis
37. Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice
38. Identification and initial characterisation of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein
39. Intranuclear foci containing low abundance herpes simplex virus latency-associated transcripts visualised by non-isotopic in situ hybridisation
40. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis
41. A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lytic-phase epitope
42. + T cells
43. Protection against lethal influenza virus encephalitis by intranasally primed CD8+ memory T cells
44. + T cells
45. Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8(+) T lymphocytes
46. Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses
47. Repression of viral transcription during herpes simplex virus latency
48. HHV-8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines
49. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus