Increased serum levels of macrophage inflammatory protein-3α in chronic viral hepatitis: Prognostic importance of macrophage inflammatory protein-3α during interferon therapy in chronic hepatitis C

Journal of Viral Hepatitis

Volumn 9, Issue 3, 2002, Pages 213-220

  Yamauchi, K ^a   Akbar, S M F ^a   Horiike, N ^a   Michitaka, K ^a   Onji, Morikazu ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Chronic hepatitis; Interferon therapy; MIP 3

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ASPARTATE AMINOTRANSFERASE; BETA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; KINETICS; LIVER CELL DAMAGE; LYMPHOCYTE; MALE; PRIORITY JOURNAL; PROGNOSIS; VIRUS HEPATITIS;

ADULT; ANTIVIRAL AGENTS; CHEMOKINES, CC; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; LIVER FUNCTION TESTS; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MIDDLE AGED; RECEPTORS, CHEMOKINE;

EID: 0036917026     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2002.00354.x     Document Type: Article

References (17)

1. Peters M, Vierling J, Gershwin ME, Millich D, Chisari FV, Hoofnagle JH. Immunology and the liver. Hepatology 1991; 13: 977-994.
2. Chisari FV. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995; 13: 29-60.
3. Napoli J, Bishop GA, McGuinness PH, Painter DM, McCaughan GW. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996; 24: 759-765.
4. Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J Immunol 1999; 1: 6236-6243.
5. Gerard C, Rollins BJ. Chemokines and disease. Nature Immunol 2001; 2: 108-115.
6. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nature Immunol 2001; 2: 123-128.
7. Schutyser E, Struyf S, Menten P et al. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. J Immunol 2000; 165: 4470-4477.
8. Iwasaki A, Kelsall BL. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3 alpha, MIP-3 beta, and secondary lymphoid organ chemokine. J Exp Med 2000; 191: 1381-1394.
9. Hieshima K, Imai T, Opdenakker G et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 1997; 272: 5846-5853.
10. Dieu-Nosjean MC, Massacrier C, Homey B et al. Macrophage inflammatory protein 3 alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 2000; 192: 705-718.
11. Homey B, Dieu-Nosjean MC, Wiesenborn A et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000; 164: 6621-6632.
12. Nakayama T, Fujisawa R, Yamada H et al. Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol 2001; 13: 95-103.
13. Shimizu Y, Murata H, Kashii Y et al. CC-chemokine receptor 6 and its ligand macrophage migration inhibitory protein 3 alpha might be involved in the amplification of focal necro-inflammatory response in the liver. Hepatology 2001; 34: 311-319.
14. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology 1994; 19: 1513-1520.
15. Ishak K, Baptisa A, Bianchi L et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699.
16. Keeffe EB, Hollinger FB. Therapy of hepatitis C. consensus interferon trials. Consensus Interferon Study Group. Hepatology 1997; 26: 101S-107S.
17. Trabaud MA, Bailly F, Si-Ahmed SN et al. Comparison of HCV RNA assays for the detection and quantification of hepatitis C virus RNA levels in serum of patients with chronic hepatitis C treated with interferon. J Med Virol 1997; 52: 105-112.