Family studies: Their role in the evaluation of genetic cardiovascular risk factors

Clinical Chemistry and Laboratory Medicine

Volumn 40, Issue 11, 2002, Pages 1085-1096

  Mansour Chemaly, Marianne ^a   Haddy, Nadia ^a   Siest, Gérard ^a   Visvikis, Sophie ^a  

^a INSERM   (France)

Author keywords

Cardiovascular risk factors; Family history; Genetic risk factors; STANISLAS cohort

Indexed keywords

ADULT; AGED; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COHORT ANALYSIS; ENVIRONMENTAL FACTOR; EVALUATION; FAMILY STUDY; FEMALE; GENE LOCATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC TRAIT; HEREDITY; HUMAN; HUMAN GENOME; MALE; PATHOPHYSIOLOGY; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

CARDIOVASCULAR DISEASES; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; FAMILY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RISK FACTORS;

EID: 0036909884     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2002.190     Document Type: Review

References (89)

1. Wood D, De Backer G, Faergeman O, Graham I, Mancia G, Pyorala K. Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis 1998; 140:199-270.
2. Myers RH, Kiely DK, Cupples LA, Kannel WB. Parental history is an independent risk factor for coronary artery disease: the Framingham Study. Am Heart J 1990; 120:963-9.
3. Fauchier L, Maison-Blanche P, Forhan A, D'Hour A, Lepinay P, Tichet J, et al. Association between heart rate-corrected QT interval and coronary risk factors in 2,894 healthy subjects (the DESIR Study). Data from an epidemiological study on the insulin resistance syndrome. Am J Cardiol 2000; 86:557-9.
4. Bensen JT, Li R, Hutchinson RG, Province MA, Tyroler HA. Family history of coronary heart disease and pre-clinical carotid artery atherosclerosis in African-Americans and whites: the ARIC study: Atherosclerosis Risk In Communities. Genet Epidemiol 1999; 16:165-78.
5. Higgins M. Epidemiology and prevention of coronary heart disease in families. Am J Med 2000; 108:387-95.
6. Ciruzzi M, Schargrodsky H, Rozlosnik J, Pramparo P, Delmonte H, Rudich V, et al. Frequency of family history of acute myocardial infarction in patients with acute myocardial infarction. Am J Cardiol 1997; 80:122-7.
7. Knuiman MW, Divitini ML, Welborn TA, Bartholomew HC. Familial correlations, cohabitation effects, and heritability for cardiovascular risk factors. Ann Epidemiol 1996; 6:188-94.
8. Lauer RM. Role of family history and family testing in cardiovascular risk assessment. Am J Med 1999; 107:14S-15S.
9. Hamby RI. Hereditary aspects of coronary artery disease. Am Heart J 1981; 101:639-49.
10. Hunt SC, Williams RR, Barlow GK. A comparison of positive family history definitions for defining risk of future disease. J Chronic Dis 1986; 39:809-21.
11. Pankow JS, Folsom AR, Province MA, Rao DC, Eckfeldt J, Heiss G, et al. Family history of coronary heart disease and hemostatic variables in middle-aged adults. Atherosclerosis Risk in Communities Investigators and Family Heart Study Research Group. Thromb Haemost 1997; 77:87-93.
12. Kardia SL, Haviland MB, Sing CF. Correlates of family history of coronary artery disease in children. J Clin Epidemiol 1998; 51:473-86.
13. An P, Rice T, Gagnon J, Borecki IB, Perusse L, Leon AS, et al. Familial aggregation of resting blood pressure and heart rate in a sedentary population: the HERITAGE Family Study. HEalth, RIsk factors, exercise Training, And GEnetics. Am J Hypertens 1999; 12:264-70.
14. De Bacquer D, De Backer G, Kornitzer M, Blackburn H. Parental history of premature coronary heart disease mortality and signs of ischemia on the resting electrocardiogram. J Am Coll Cardiol 1999; 33:1491-8.
15. Snowden CB, McNamara PM, Garrison RJ, Feinleib M, Kannel WB, Epstein FH. Predicting coronary heart disease in siblings - a multivariate assessment: the Framingham Heart Study. Am J Epidemiol 1982; 115:217-22.
16. Feinleib M. The Framingham Study: sample selection, follow-up, and methods of analysis. Natl Cancer Inst Monogr 1985; 67:59-64.
17. http://www.framingham.com/heart/backgrnd.htm
18. Dawber, TR. Summary of recent literature regarding cigarette smoking and coronary heart disease. Circulation 1960; 22:164-6.
19. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes JI. Factors of risk in the development of coronary heart disease - six year follow-up experience; the Framingham Study. Ann Intern Med 1961; 55:33-50.
20. Kannel WB. Habitual level of physical activity and risk of coronary heart disease: the Framingham Study. Can Med Assoc J 1967; 96:811-2.
21. Thomas HEJ, Kannel WB, McNamara PM. Obesity: a hazard to health. Med Times 1967; 95:1099-106.
22. Kannel WB, Wolf PA, Verter JI, McNamara PM. Epidemiologic assessment of the role of blood pressure in stroke; the Framingham Study. J Am Med Assoc 1970; 214:301-10.
23. Haynes SG, Levine S, Scotch N, Feinleib M, Kannel WB. The relationship of psychosocial factors to coronary heart disease in the Framingham Study. I. Methods and risk factors. Am J Epidemiol 1978; 107:362-83.
24. Anderson KM, Castelli WP, Levy D. Cholesterol and mortality. 30 years of follow-up from the Framingham Study. J Am Med Assoc 1987; 257:2176-80.
25. Kannel WB, D'Agostino RB, Belanger AJ. Fibrinogen, cigarette smoking, and risk of cardiovascular disease: insights from the Framingham Study. Am Heart J 1987; 113:1006-10.
26. Genest JJ, McNamara JR, Salem DN, Wilson PWF, Schaefer EJ, Malinow MR. Plasma homocysteine levels in men with premature coronary artery disease. J Am Coll Cardiol 1990; 16:1114-9.
27. Abbott RD, Wilson PWF, Kannel WB, Castelli WR High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study. Arteriosclerosis 1988; 8:207-11.
28. Post WS, Larson MG, Levy D. Impact of left ventricular structure on the incidence of hypertension: the Framingham Heart Study. Circulation 1994; 90:179-85.
29. Post WS, Levy D. New developments in the epidemiology of left ventricular hypertrophy. Curr Opin Cardiol 1994; 9:534-41.
30. Liao YL, McGee DL, Cooper RS, Sutkowski MBE. How generalizable are coronary risk prediction models? Comparison of Framingham and two national cohorts. Am Heart J 1999; 137:837-45.
31. D'Agostino RB, Russell MW, Huse DM, Ellison RC, Silbershatz H, Wilson PWF, et al. Primary and subsequent coronary risk appraisal: new results from the Framingham Study. Am Heart J 2000; 139:272-81.
32. Namboodiri KK. Framingham Heart Study: review of genetic data and design, limitations and prospects. Prog Clin Biol Res 1984; 147:65-78.
33. Feinleib M, Kannel WB, Garrison RJ, McNamara PM, Castelli WP. The Framingham Offspring Study. Design and preliminary data. Prev Med 1975; 4:518-25.
34. Shearman AM, Ordovas JM, Cupples LA, Schaefer EJ, Harmon MD, Shao Y, et al. Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genomewide scan in the Framingham Study. Hum Mol Genet 2000; 9:1315-20.
35. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998; 97:1766-72.
36. Coon H, Myers RH, Borecki 113, Arnett DK, Hunt SC, Province MA, et al. Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus: the NHLBI Family Heart Study. Arterioscler Thromb Vasc Biol 2000; 20:2275-80.
37. Feitosa MF, Borecki IB, Rich SS, Arnett DK, Sholinsky P, Myers RH, et al. Genome scan for body mass index in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 2000; 67:Suppl 2:49.
38. Jacques PF, Bostom AB, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg RH, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93:7-9.
39. Ludwig EH, Borecki IB, Ellison RC, Folsom AR, Heiss G, Higgins M, et al. Associations between candidate loci angiotensin-converting enzyme and angiotensinogen with coronary heart disease and myocardial infarction: the NHLBI Family Heart Study. Ann Epidemiol 1997; 7:3-12.
40. Arnett DK, Borecki IB, Ludwig EH, Pankow JS, Myers RH, Evans GW, et al. Angiotensinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: the Atherosclerosis Risk in Communities and the NHLBI Family Heart Studies. Atherosclerosis 1998; 138:111-6.
41. Pankow JS, Arnett DK, Borecki IB, Hunt SC, Eckfeldt JH, Folsom AR, et al. Lack of association between the angiotensin-converting enzyme insertion/deletion polymorphism and plasminogen activator inhibitor-1 antigen levels; the NHLBI Family Heart Study. Blood Coagul 2000; 11:551 -8.
42. Tsai MY, Arnett DK, Eckfeldt JH, Williams RR, Ellison RC. Plasma homocysteine and its association with carotid intimal-medial wall thickness and prevalent coronary heart disease: NHLBI Family Heart Study. Atherosclerosis 2000; 151:519-24.
43. Hong, U, Leppert MF, Lin J, Hunt SC, Rich SS, Arnett DK, et al. No evidence of linkage between the very-low density lipoprotein receptor gene and fasting serum insulin or homeostasis model assessment insulin resistance index: the NHLBI Family Heart Study. Metabolism 2000; 49:293-7.
44. Hunt SC, Province MA, Atwood LD, Sholinsky P, Lalouel J-M, Rao DC, et al. No linkage of the lipoprotein lipase locus to hypertension in Caucasians; the NHLBI Family Heart Study. J Hypertens 1999; 17:39-43.
45. Wilk JB, Djousse L, Arnett DK, Rich SS, Province MA, Hunt SC, et al. Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study. Genet Epidemiol 2000; 19:81-94.
46. Visvikis S, Sass C, Pallaud C, Grow MA, Zannad F, Siest G, et al. Familial studies on the genetics of cardiovascular diseases: the STANISLAS cohort. Clin Chem Lab Med 2000; 38:827-32.
47. Siest G, Visvikis S, Herbeth B, Gueguen R, Vincent-Viry M, Sass C, et al. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the STANISLAS cohort. Clin Chem Lab Med 1998; 36:35-42.
48. Siest G, Henny J, Galteau MM, Schiele F, Steinmetz J, Visivikis S. Lipid and lipoprotein genetic variability: an important contribution from the French health examination centers. Clin Biochem 1995; 28:31-8.
49. Salah D, Bohnet K, Gueguen R, Siest G, Visvikis S. Combined effects of lipoprotein lipase and apolipoprotein E polymorphisms on lipid and lipoprotein levels in the STANISLAS cohort. J Lipid Res 1997; 38:904-12.
50. Zannad F, Visvikis S, Gueguen R, Sass C, Chapet O, Herbeth B, et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998; 103:183-8.
51. Pallaud C, Sass C, Zannad F, Siest G, Visvikis S. APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the STANISLAS cohort). Clin Genet 2001; 59:316-24.
52. 447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness and femoral arteries in healthy subjects from the STANISLAS cohort. Atherosclerosis 1998; 140:89-95.
53. Sass C, Pallaud C, Zannad F, Visvikis S. Relationship between E-selectin L/F554 polymorphism and blood pressure in the STANISLAS cohort. Hum Genet 2000; 107:58-61.
54. Pallaud C, Gueguen R, Sass C, Grow M, Cheng S, Siest G, et al. Genetic influences on lipid metabolism trait variability within the STANISLAS cohort. J Lipid Res 2001; 42:1879-90.
55. Pallaud C. Détermination d'un profil génétique de risque cardiovasculaire: approche épidémiologique. PhD thesis 2001. Université Henri Poincaré-Nancy 1.
56. Wilmore JH, Stanforth PR, Gagnon J, Leon AS, Rao DC, Skinner JS, et al. Endurance exercise training has a minimal effect on resting heart rate: the HERITAGE Study. Med Sci Sports Exerc 1996; 28:829-35.
57. Gu C, Borecki I, Gagnon J, Bouchard C, Leon AS, Skinner JS, et al. Familial resemblance for resting blood pressure with particular reference to racial differences: preliminary analyses from the HERITAGE Family Study. Hum Biol 1998; 70:77-90.
58. An R Rice T, Perusse L, Borecki IB, Gagnon J, Leon AS, et al. Complex segregation analysis of blood pressure and heart rate measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study. Am J Hypertens 2000; 13:488-97.
59. Rankinen T, Rice T, Perusse L, Chagnon YC, Gagnon J, Leon AS, et al. NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE Family Study. Hypertension 2000; 36:885-9.
60. Rankinen T, Perusse L, Borecki I, Chagnon YC, Gagnon J, Leon AS, et al. The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE Family Study. J Appl Physiol 2000; 88:346-51.
61. Rice T, Province M, Perusse L, Bouchard C, Rao DC. Cross-trait familial resemblance for body fat and blood pressure: familial correlations in the Quebec Family Study. Am J Hum Genet 1994; 55:1019-29.
62. Oppert JM, Vohl MC, Chagnon M, Dionne FT, Cassard-Doulcier AM, Ricquier D, et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes 1994; 18:526-31.
63. Bouchard C, Rice T, Lemieux S, Despres JP, Perusse L, Rao DC. Major gene for abdominal visceral fat area in the Quebec Family Study. Int J Obes 1996; 20:420-7.
64. Couillard C, Lemieux S, Moorjani S, Lupien PJ, Theriault G, Prud'homme D, et al. Associations between 12 year changes in body fatness and lipoprotein-lipid levels in men and women of the Quebec Family Study. Int J Obes 1996; 20:1081-8.
65. Katzmarzyk PT, Malina RM, Song TM, Bouchard C. Television viewing, physical activity, and health-related fitness of youth in the Quebec Family Study. J Adolesc Health 1998; 23:318-25.
66. Bouchard C. Genetics of human obesity: recent results from linkage studies. J Nutr 1997; 127:1887S-90S.
67. Perusse L, Rice T, Chagnon YC, Despres JP, Lemieux S, Roy S, et al. A genome-wide scan for abdominal fat assessed by computed tomography in the Quebec Family Study. Diabetes 2001; 50:614-21.
68. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L, Borecki IB, et al. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec Family Study. Circulation 2000; 102:1956-63.
69. Ukkola O, Perusse L, Weisnagel SJ, Bergeron J, Despres JP, Rao DC, et al. Interactions among the glucocorticoid receptor, lipoprotein lipase, and adrenergic receptor genes and plasma insulin and lipid levels in the Quebec Family Study. Metabolism 2001; 50:246-52.
70. Goble A, Jackson B, Phillips P, Race E, Oliver RG, Worcester MC. The Family Atherosclerosis Risk Intervention Study (FARIS): risk factor profiles of patients and their relatives following an acute cardiac event. Aust N Z J Med 1997; 27:568-77
71. Bhattacharyya S, Leaves NI, Wiltshire S, Cox R, Cookson WO. A high-density genetic map of the chromosome 13q14 atopy locus. Genomics 2000; 70:286-91.
72. Watt G, McConnachie A, Upton M, Emslie C, Hunt K. How accurately do adult sons and daughters report and perceive parental deaths from coronary disease? J Epidemiol Community Health 2000; 54:859-63.
73. Fuentes RM, Notkola IL, Shemeikka S, Tuomilehto J, Nissinen A. Familial aggregation of serum total cholesterol: a population-based family study in eastern Finland. Prev Med 2000; 31:603-7.
74. Kosch A, Junker R, Kurnik K, Schobess R, Gunther G, Koch H, et al. Prothrombotic risk factors in children with spontaneous venous thrombosis and their asymptomatic parents: a family study. Thromb Res 2000; 99:531-7.
75. Lamont DW, Parker L, Cohen MA, White M, Bennett SM, Unwin NC, et al. Early life and later determinants of adult disease: a 50 year follow-up study of the Newcastle Thousand Families cohort. Public Health 1998; 112:85-93.
76. Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, et al. Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension 1998; 31:725-9.
77. Friedlander Y, Elkana Y, Sinnreich R, Kark JD. Genetic and environmental sources of fibrinogen variability in Israeli families: the Kibbutzim Family Study. Am J Hum Genet 1995; 56:1194-206.
78. Sinnreich R, Friedlander Y, Luria MH, Sapoznikov D, Kark JD. Inheritance of heart rate variability: the Kibbutzim Family Study. Hum Genet 1999; 105:654-61.
79. Bielak LF, Sheedy PF, Peyser PA. Coronary artery calcification measured at electron-beam CT: agreement in dual scan runs and change over time. Radiology 2001; 218:224-9.
80. (http://www.sfbr.org/sfbr/public/research/mapp.html).
81. (http://www.sfbr.org/sfbr/public/research/strongheart.html).
82. Pereira MA, Schreiner PJ, Pankow JS, Williams RR, Higgins M, Province MA, et al. The Family Risk Score for coronary heart disease: associations with lipids, lipoproteins, and body habitus in a middle-aged bi-racial cohort: the ARIC study. Ann Epidemiol 2000; 10:239-45.
83. Higgins M, Province M, Heiss G, Eckfeldt J, Ellison RC, Folsom AR, et al. NHLBI Family Heart Study: objectives and design. Am J Epidemiol 1996; 143:1219-28.
84. Li R, Bensen JT, Hutchinson RG, Province MA, Hertz-Picciotto I, Sprafka JM, et al. Family risk score of coronary heart disease (CHD) as a predictor of CHD: the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI Family Heart Study. Genet Epidemiol 2000; 18:236-50.
85. Siest G, Visvikis S, Zaiou M, Regis A, Jaid M, Steinmetz J, et al. The role of genetics in defining reference values and health status. Methods Inf Med 1993; 32:255-9.
86. Lecomte E, Herbeth B, Nicaud V, Rakotovao R, Arthur Y, Tiret L. Segregation analysis of fat mass and fat-free mass with age and sex-dependent effects: the STANISLAS Family Study. Genet Epidemiol 1997; 14:51-62.
87. Pérusse L, Rice T, Després JP, Bergeron J, Province M, Gagnon J, et al. Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study. Arterioscler Thromb Vasc Biol 1997; 11:3263-9.
88. Pérusse L, Rice T, Després JP, Rao DC, Bouchard C. Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study. Arterioscler Thromb Vasc Biol 1997; 11:3270-7.
89. http://www.nhlbi.nih.gov