In vitro induction of micronuclei and chromosome aberrations by quinolones: Possible mechanisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 352, Issue 1-2, 1996, Pages 143-150

  Curry, Patrick T ^a   Kropko, Melvin L ^b   Garvin, Jeffrey R ^b   Fiedler, Ronald D ^c   Theiss, Jeffrey C ^b  

^a Microbiological Associates Inc   (United States)

^b PFIZER INC   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Chromosome aberration; Chromosome stickiness; Ciprofloxacin; Genotoxic mechanism; Micronuclei; PD 124816; Quinolone; Topoisomerase II

Indexed keywords

5 AMINO 7 (3 AMINO 1 PYRROLIDINYL) 1 CYCLOPROPYL 6,8 DIFLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; CIPROFLOXACIN; CYTOCHALASIN B; DEMECOLCINE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL STRAIN V 79; CELL SURVIVAL; CENTROMERE; CHINESE HAMSTER; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG STRUCTURE; ENZYME INHIBITION; GENOTOXICITY; LUNG ALVEOLUS CELL; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL CHROMOSOME ABERRATION;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0029982322     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(96)00002-4     Document Type: Article

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