Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor

Journal of Bone and Mineral Research

Volumn 11, Issue 5, 1996, Pages 578-586

  Blind, Eberhard ^a,b,c   Bambino, Tom ^a,b   Huang, Zhengmin ^a,b   Bliziotes, Michael ^d   Nissenson, Robert A ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTORADIOGRAPHY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; OPOSSUM; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION;

EID: 0029914846     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110505     Document Type: Article

References (44)

1. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, Jr. Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from ral osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736.
2. Schipani E, Karga H, Karaplis A, Potts JT, Jr, Kronenberg H, Segre GV, Abou-Samra A, Jüppner H 1993 Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 132:2157-2165.
3. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LFJ, Hock J, Potts JT, Jr, Kronenberg HM, Segre GV 1991 A G-protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026.
4. Jüppner H, Abou-Samra A, Uneno S, Gu WX, Potts JT, Jr, Segre GV 1988 The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 263:8557-8560.
5. Nissenson RA, Diep D, Strewler GJ 1988 Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem 263:12866-12871.
6. Fukayama S, Tashjian AH, Jr, Bringhurst FR 1992 Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells. Endocrinology 131:1757-1769.
7. Pun KK, Ho PW, Nissenson RA, Arnaud CD 1990 Desensitization of parathyroid hormone receptors on cultured bone cells. J Bone Miner Res 5:1193-1200.
8. Yamamoto I, Shigeno C, Potts JT, Jr. Segre GV 1988 Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells. Endocrinology 122:1208-1217.
9. Urena P, Iida KA, Kong XF, Jüppner H, Kronenberg HM, Abou-Samra AB, Segre GV 1994 Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells. Endocrinology 134:451-456.
10. Fukayama S, Schipani E, Jüppner H, Lanske B, Kronenberg HM, Abou-Samra A, Brmghurst FR 1994 Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells. Endocrinology 134:1851-1858.
11. Fukayama S, Tashjian A, Jr, Bringhurst FR 1992 Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells. Endocrinology 131:1757-1769.
12. Mitchell J, Goltzman D 1990 Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106. Endocrinology 126: 2650-2660.
13. Teitelbaum AP, Silve CM, Nyiredy KO, Arnaud CD 1986 Down-regulation of parathyroid hormone (PTH) receptors in cultured bone cells is associated with agonist-specific intracellular processing of PTH-receptor complexes. Endocrinology 118:595-602.
14. Civitelli R, Martin TJ, Fausto A, Gunsten SL, Hruska KA, Avioli LV 1989 Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: Comparison with parathyroid hormone. Endocrinology 125:1204-1210.
15. Babich M, Alford GE, Nissenson RA 1994 A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid-stimulated signaling pathways in rat osteosarcoma cells. J Pharmacol Exptl Ther 269:172-177.
16. Sugimoto T, Kano J, Ikeda K, Fukase M, Chihara K 1993 Interaction of parathyroid hormone-related peptide-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: role in PTHrP-induced homologous desensitization. J Bone Miner Res 8:451-458.
17. Segre GV, Goldring SR 1993 Receptors for secretin. calcitonin. parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4:309-314.
18. Chen R, Lewis KA, Perrin MH, Vale WW 1993 Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci USA 90:8967-8971.
19. Blind E, Bambino T, Nissenson RA 1995 Agonist-stimulated phosphorylation of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein. Endocrinology 136:4271-4277.
20. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ 1991 Model systems for the study of seven-transmembrane-segment receptors. Ann Rev Biochem 60:653-688.
21. Lee SK, Stern PH 1994 Studies on the mechanism of desensitization of the parathyroid hormone-stimulated calcium signal in UMR-106 cells: Reversal of desensitization by alkaline phosphatase but not by protein kinase C downregulation. J Bone Miner Res 9:781-789.
22. Hausdorff WP, Caron MG, Lefkowitz RJ 1990 Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J 4:2881-2889.
23. Lefkowitz RJ, Hausdorff WP, Caron MG 1990 Role of phosphorylation in desensitization of the beta-adrenoceptor. Trends Pharmacol Sci 11:190-194.
24. Lefkowitz RJ 1993 G protein-coupled receptor kinases. Cell 74:409-412.
25. Patridge N, Kemp B, Veroni M, Martin T 1981 Activation of adenosine 3′,5′-monophosphate-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2 and prostacyclin. Endocrinology 108:220-225.
26. Chase L, Fedak S, Aurbach G 1969 Activation of skeletal adenyl cyclase by parathyroid hormone in vitro. Endocrinology 84:761-768.
27. Donahue HJ, Fryer MJ, Eriksen EF, Heath H, III 1988 Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells. J Biol Chem 263:13522-13527.
28. Babich M, King KL, Nissenson RA 1989 G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes. J Bone Miner Res 4:549-556.
29. Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA 1988 PTH elevates inositol polyp ho sphates and diacylglycerol in a rat osteoblast-like cell line. Am J Physiol 255:E660-E667.
30. Abou-Samra AB, Jüppner H, Westerberg D, Potts JT, Jr, Segre GV 1989 Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells. Endocrinology 124:1107-1113.
31. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ 1989 Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science 246:235-240.
32. Deng W, Nickoloff J 1992 Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal Biochem 200:81-88.
33. Huang Z, Chen Y, Nissenson RA 1995 The cytoplasmic tail of the G-protein coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem 270:151-156.
34. Sambrook J, Fritsch E, Maniatis T 1989 Expression of cloned genes in cultured mammalian cells. In: Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring; Harbor Laboratory, Cold Spring Harbor, NY. pp. 16.33-16.36.
35. Harlow E, Lane D 1988 Immunoprecipitation. In: Antibodies. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 451-470.
36. Iida-Klein A, Guo J, Xie L, Jüppner H, Potts JT, Jr, Kronenberg HM, Bringhurst F, Abou-Samra AB, Segre GV 1995 Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C. J Biol Chem 270:8458-8465.
37. Kennelly P, Krebs E 1991 Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 266:15555-15558.
38. Liggett SB, Bouvier M, Hausdorff WP, O'Dowd B, Caron MG. Lefkowitz RJ 1989 Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. Mol Pharmacol 36:641-646.
39. Hausdorff WP, Bouvier M, O'Dowd BF, Irons GP, Caron MG, Lefkowitz RJ 1989 Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem 204:12657-12665.
40. Hausdorff WP, Campbell PT, Ostrowski J, Yu SS, Caron MG, Lefkowitz RJ 1991 A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. Proc Natl Acad Sci USA 88:2979-2983.
41. 2A-adrenergic receptor. J Biol Chem 270:4681-4688.
42. Nygaard S, Kuestner R, Moore E, Stroop S 1995 Phosphorylation of the calcitonin receptor localized at the C-terminus. J Bone Miner Res 10 (Suppl 1):S141 (abstract 10).
43. Hipkin RW, Sanchez-Yagüe J, Ascoli M 1993 Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line. Mol Endocrinol 7:823-832.
44. Hipkin RW, Zheng W, Ascoli M 1995 Human chorionic gonadotropin (CG)- and phorbol ester-stimulated phosphorylation of the luteinizing hormone/CG receptor maps to serines 635, 639, 649, and 652 in the C-terminal cytoplasmic tail. Mol Endocrinol 9:151-158.