Membrane rafts in immunoreceptor signaling: New doubts, new proofs?

Trends in Immunology

Volumn 23, Issue 12, 2002, Pages 562-564

  Hořejší, Václav ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM ION; CD59 ANTIGEN; CHOLESTEROL; CHOLESTEROL OXIDASE; FC RECEPTOR; MEMBRANE LIPID; MEMBRANE PROTEIN; METHYL BETA CYCLODEXTRIN; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRITON X 100;

CELL FUNCTION; CELL SHAPE; EXTRACTION; HUMAN; LYMPHOCYTE MEMBRANE; PROTEIN DOMAIN; PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0036900081     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02330-X     Document Type: Review

References (20)

1. Germain R.N. The T-cell receptor for antigen: signaling and ligand discrimination. J. Biol. Chem. 276:2001;35223-35226.
2. Werlen G., Palmer E. The T-cell receptor signalosome: a dynamic structure with expanding complexity. Curr. Opin. Immunol. 14:2002;299-305.
3. Xavier R., et al. Membrane compartmentation is required for efficient T-cell activation. Immunity. 8:1998;723-732.
4. Kabouridis P.S., et al. Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. Eur. J. Immunol. 30:2000;954-963.
5. Ilangumaran S., Hoessli D.C. Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem J. 335:1998;433-440.
6. Pizzo P., et al. Lipid rafts and T-cell receptor signaling: a critical revaluation. Eur. J. Immunol. 32:2002;3082-3091.
7. Surviladze Z., et al. Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein. Eur. J. Immunol. 31:2001;1-10.
8. Drevot P., et al. TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J. 21:2002;1899-1908.
9. Zeyda M., et al. LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T-cell signaling by polyunsaturated fatty acids. J. Biol. Chem. 277:2002;28418-28423.
10. Tuosto L., et al. Organization of plasma membrane functional rafts upon T-cell activation. Eur. J. Immunol. 31:2001;345-349.
11. Kabouridis P.S., et al. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:1997;4983-4998.
12. Zhang W., et al. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T-cell activation. Immunity. 9:1998;239-246.
13. Kosugi A., et al. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity. 14:2001;669-680.
14. Rouquette-Jazdanian A.K., et al. Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor. Biochem. J. 363:2002;645-655.
15. Delgado P., et al. CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature. 406:2000;426-430.
16. Werlen G., et al. A motif in the αβT-cell receptor controls positive selection by modulating ERK activity. Nature. 406:2000;422-426.
17. Doucey, M.A. et al. (2002) CD3δ establishes a functional link between the T-cell receptor and CD8. J. Biol. Chem. DOI: 10.1074/jbc.M20811920.
18. Schade J.I., et al. Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction. J. Immunol. 168:2002;2233-2239.
19. Gomez-Mouton C., et al. Segregation of leading-edge and uropod components into specific lipid rafts during T-cell polarization. Proc. Natl. Acad. Sci. U. S. A. 98:2001;9642-9647.
20. Nix M., Stoffel W. Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T-cell receptor stimulation. Cell Death Differ. 7:2000;413-424.