Ethanol antagonizes kainate receptor-mediated inhibition of evoked GABAA inhibitory postsynaptic currents in the rat hippocampal CA1 region

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 3, 2002, Pages 937-944

  Crowder, T L ^a   Ariwodola, O J ^a   Weiner, J L ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ALCOHOL; KAINIC ACID; KAINIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HIPPOCAMPUS; KAINIC ACID; MALE; RATS; RECEPTORS, GABA-A; RECEPTORS, KAINIC ACID; SYNAPTIC TRANSMISSION;

EID: 0036895853     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.038471     Document Type: Article

References (42)

1. Ben-Ari Y and Cossart R (2000) Kainate, a double agent that generates seizures: Two decades of progress. Trends Neurosci 23:580-587.
2. Bureau I, Bischoff S, Heinemann SF, and Mulle C (1999) Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J Neurosci 19:653-663.
3. Chandler LJ, Harris RA, and Crews FT (1998) Ethanol tolerance and synaptic plasticity. Trends Pharmacol Sci 19:491-495.
4. Chergui K, Bouron A, Normand E, and Mulle C (2000) Functional GluR6 kainate receptors in the striatum: Indirect down-regulation of synaptic transmission. J Neurosci 20:2175-2182.
5. Chittajallu R, Braithwaite SP, Clarke VR, and Henley JM (1999) Kainate receptors: Subunits, synaptic localization and function. Trends Pharmacol Sci 20:26-35.
6. Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL, and Henley JM (1996) Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature (Lond) 379:78-81.
7. Cossart R, Esclapez M, Hirsch JC, Bernard C, and Ben-Ari Y (1998) GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells. Nat Neurosci 1:470-478.
8. Crowder TL and Weiner JL (2002) Functional characterization of kainate receptors in the rat nucleus accumbens core region. J Neurophysiol 88:41-48.
9. Davies CH, Davies SN, and Collingridge GL (1990) Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J Physiol (Lond) 424:513-531.
10. Deitrich RA, Dunwiddie TV, Harris RA, and Erwin VG (1989) Mechanism of action of ethanol: Initial central nervous system actions. Pharmacol Rev 41:489-537.
11. Dildy-Mayfield JE and Harris RA (1992) Comparison of ethanol sensitivity of rat brain kainate, DL-α-amino-3 hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 262:487-494.
12. Everts I, Villmann C, and Hollmann M (1997) N-Glycosylation is not a prerequisite for glutamate receptor function but Is essential for lectin modulation. Mol Pharmacol 52:861-873.
13. Faingold CL, N'Gouemo P, and Riaz A (1998) Ethanol and neurotransmitter interactions-from molecular to integrative effects. Prog Neurobiol. 55:509-535.
14. Frerking M, Malenka RC, and Nicoll RA (1998) Synaptic activation of kainate receptors on hippocampal interneurons. Nat Neurosci 1:479-486.
15. Frerking M and Nicoll RA (2000) Synaptic kainate receptors. Curr Opin Neurobiol 10:342-351.
16. Frerking M, Petersen CC, and Nicoll RA (1999) Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proc Natl Acad Sci USA 96:12917-12922.
17. A receptors expressed in mammalian cells and Xenopus oocytes. Alcohol Clin Exp Res 21:444-451.
18. Jiang L, Xu J, Nedergaard M, and Kang J (2001) A kainate receptor increases the efficacy of GABAergic synapses. Neuron 30:503-513.
19. Kang MH, Spigelman I, and Olsen RW (1998) Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. Alcohol Clin Exp Res 22:2165-2173.
20. Lerma J, Paternain AV, Rodriguez-Moreno A, and Lopez-Garcia JC (2001) Molecular physiology of kainate receptors. Physiol Rev 81:971-998.
21. Lovinger DM (1993). High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells. Neurosci Lett 159:83-87.
22. Lovinger DM, White G, and Weight FF (1990) Ethanol inhibition of neuronal glutamate receptor function. Ann Med 22:247-252.
23. 2+. Brain Res 546:227-234.
24. Martin D, Tayyeb MI, and Swartzwelder HS (1995) Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. Alcohol Clin Exp Res 19:1312-1316.
25. Masood K, Wu C, Brauneis U, and Weight FF (1994) Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 45:324-329.
26. Mayer ML and Westbrook GL (1987) The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol (NY) 28:197-276.
27. Min MY, Melyan Z, and Kullmann DM (1999) Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors. Proc Natl Acad Sci USA 96:9932-9937.
28. Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, and Niki H (1997) Fyn-kinase as a determinant of ethanol sensitivity: Relation to NMDA-receptor function. Science (Wash DC) 278:698-701.
29. Mulle C, Sailer A, Swanson GT, Brana C, O'Gorman S, Bettler B, and Heinemann SF (2000) Subunit composition of kainate receptors in hippocampal interneurons. Neuron 28:475-484.
30. Nie Z, Madamba SG, and Siggins GR (1994) Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther 271:1566-1573.
31. Paternain AV, Morales M, and Lerma J (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
32. Poelchen W, Proctor WR, and Dunwiddie TV (2000) The in vitro ethanol sensitivity of hippocampal synaptic γ-aminobutyric acid(A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol. J Pharmacol Exp Ther 295:741-746.
33. Standley S and Baudry M (2000) The role of glycosylation in ionotropic glutamate receptor ligand binding, function, and trafficking. Cell Mol Life Sci 57:1508-1516.
34. Tsai G and Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49:173-184.
35. Valenzuela CF, Bhave S, Hoffman P, and Harris RA (1998a) Acute effects of ethanol on pharmacologically isolated kainate receptors in cerebellar granule neurons: Comparison with NMDA and AMPA receptors. J Neurochem 71:1777-1780.
36. Valenzuela CF and Cardoso RA (1999) Acute effects of ethanol on kainate receptors with different subunit compositions. J Pharmacol Exp Ther 288:1199-1206.
37. Valenzuela CF, Cardoso RA, Lickteig R, Browning MD, and Nixon KM (1998b) Acute effects of ethanol on recombinant kainate receptors: Lack of role of protein phosphorylation. Alcohol Clin Exp Res 22:1292-1299.
38. Volpicelli JR (2001) Alcohol abuse and alcoholism: An overview. J Clin Psychiatry 62 (Suppl 20):4-10.
39. Weiner JL, Dunwiddie TV, and Valenzuela CF (1999) Ethanol inhibition of synaptically evoked kainate responses in rat hippocampal CA3 pyramidal neurons. Mol Pharmacol 56:85-90.
40. A synapses onto rat hippocampal CA1 pyramidal neurons. J Neurophysiol 77:1306-1312.
41. Wirkner K, Eberts C, Poelchen W, Allgaier C, and Illes P (2000) Mechanism of inhibition by ethanol of NMDA and AMPA receptor channel functions in cultured rat cortical neurons. Naunyn-Schmiedeberg's Arch Pharmacol 362:568-576.
42. Woodward JJ (2000) Ethanol and NMDA receptor signaling. Crit Rev Neurobiol 14:69-89.