Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice

Journal of Neuroscience

Volumn 19, Issue 2, 1999, Pages 653-663

  Bureau, Ingrid ^a   Bischoff, Serge ^b   Heinemann, Steve F ^c   Mulle, Christophe ^a  

^a CNRS   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

CA1 interneurons; CA1 pyramidal cells; GluR6 knock out mouse; GYKI 53655; Kainate receptors; NBQX

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 4 AMINOBUTYRIC ACID RECEPTOR; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR ANTAGONIST; DOMOIC ACID; GLUTAMATE RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; MALE; MOUSE; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPTIC INHIBITION;

EID: 0033555878     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-02-00653.1999     Document Type: Article

References (35)

1. Ankri N, Legendre P, Faber DS, Korn H (1994) Automatic detection of spontaneous synaptic responses in central neurones. J Neurosci Methods 52:87-100.
2. Bettler B, Mulle C (1995) AMPA and kainate receptors. Neuropharmacology 34:123-139.
3. Bischoff S, Barhanin J, Bettler B, Mulle C, Heinemann S (1997) Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon. J Comp Neurol 379:541-562.
4. Bleakman D, Ballyk BA, Schoepp DD, Palmer AJ, Bath CP, Sharpe EF, Woolley ML, Bufton HR, Kamboj RK, Tarnawa I, Lodge D (1996) Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 35:1689-1702.
5. Castillo PE, Malenka RC, Nicoll RA (1997) Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388:182-186.
6. Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL, Henley JM (1996) Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature 379:78-81.
7. Clarke VRJ, Ballyk BA, Hoo KH, Mandelzys A, Pellizzari A, Bath CP, Thomas J, Sharpe EF, Davies CH, Ornstein PL, Schoepp DD, Kamboj RK, Collingridge GL, Lodge D, Bleakman D (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389:599-603.
8. Egebjerg J, Bettler B, Hermans-Borgmeyer I, Heinemann S (1991) Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351:745-748.
9. Fisher R, Alger B (1984) Electrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice. J. Neurosci 4:1312-1323.
10. Freund T, Buzsaki G (1996) Interneurons of the hippocampus. Hippocampus 6:347-470.
11. Herb A, Burnashev N, Werner P, Sakmann B, Wisden W, Seeburg PH (1992) The KA-2 subunit of excitatory amino acid receptor shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 8:775-785.
12. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
13. Howe J (1996) Homomeric and heteromeric ion channels formed from the kainate-type subunits GluR6 and KA2 have very small but different unitary conductances. J Neurophysiol 76:510-519.
14. Huettner (1990) Glutamate receptor channels in rat DRG neurons -activation by kainate and quisqualate and blockade of desensitization by Con-A. Neuron 5:255-266.
15. 2++ influx and EPSP in area CA1 of the rat hippocampus. J Physiol (Lond) 509:833-846.
16. Lerma J, Paternain AV, Naranjo JR, Mellstrom B (1993) Functional kainate selective glutamate receptors in cultured hippocampal neurons. Proc Natl Acad Sci USA 90:11688-11692.
17. Llano I, Marty A (1995) Presynaptic metabotropic regulation of inhibitory synapses in rat cerebellar slices. J Physiol (Lond) 486:163-176.
18. Mulle C, Andreas S, Pérez-Otaño I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Bettler B, Heinemann SF (1998) Altered synaptic physiology and reduced susceptibility to kainate induced seizures in GluR6-deficient mice. Nature 392:601-604.
19. Nakanishi N (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
20. Partin K, Patneau D, Winters C, Mayer M, Buonanno A (1993) Selective modulation of desensitization at AM PA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082.
21. Paternain A, Morales M, Lerma J (1995) Selective antagonism of AMPA receptor unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
22. Paternain AV, Vicente A, Nielsen EO, Lerma J (1996) Comparative antagonism of kainate-activated kainate and AM PA receptors in hippocampal neurons. Eur J Neurosci 8:2129-2136.
23. Represa A, Tremblay E, Ben-Ari Y (1987) Kainic binding sites in the hippocampal mossy fibers: localization and plasticity. Neuroscience 20:739-748.
24. Robinson JH, Deadwyler SA (1981) Kainic acid produces depolarization of CA3 pyramidal cells in the in vitro hippocampal slice. Brain Res 221:117-127.
25. Rodriguez-Moreno A, Herrera O, Lerma J (1997) Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19:893-901.
26. Sahara Y, Noro N, Iida Y, Soma K, Nakamura Y (1997) Glutamate receptor subunits GluRS and KA-2 are coexpressed in rat trigeminal ganglion neurons. J Neurosci 17:6611-6620.
27. Seeburg PH (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci 14:297-303.
28. Sheardown M, Nielsen E, Hansen A, Jacobsen P, Honoré T (1990) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-574.
29. Sloviter R, Damiano B (1981) On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage. Neuropharmacology 20:1001-1011.
30. Vignes M, Collingridge GL (1997) The synaptic activation of kainate receptors. Nature 388:179-182.
31. Westbrook G, Lothman E (1983) Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity. Brain Res 273:97-109.
32. Wilding T, Huettner J (1997) Activation and desensitization of hippocampal kainate receptors. J Neurosci 17:2713-2721.
33. Wilding TJ, Huettner JE (1995) Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol Pharmacol 47:582-587.
34. Wilding TJ, Huettner JE (1996) Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring receptors. Mol Pharmacol 49:540-546.
35. Wisden W, Seeburg P (1993) A complex mosaic of high-affinity kainate receptors in rat brain. J Neurosci 13:3582-3598.