Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells

Cancer

Volumn 85, Issue 9, 1999, Pages 1937-1942

  Lin, Heng Liang ^a   Liu, Tsung Yun ^a   Lui, Wing Yiu ^a   Chi, Chin Wen ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Berberine; Flaw cytometry; Hepatoma; Multidrug resistance transporter rhodamine 123

Indexed keywords

B 3251; BERBERINE; CARRIER PROTEIN; RHODAMINE 123; TAMOXIFEN; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BERBERINE; CARCINOMA, HEPATOCELLULAR; DRUGS, CHINESE HERBAL; HUMANS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; P-GLYCOPROTEIN; TAMOXIFEN; TUMOR CELLS, CULTURED; UP-REGULATION; VERAPAMIL;

EID: 0033135821     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19990501)85:9<1937::AID-CNCR9>3.0.CO;2-F     Document Type: Article

References (36)

1. Thibaut F, Tsuruo T, Hamada H, Gottsman MM, Pastan I, Willingham MC. Cellular localization of the multidrug-resistance gene product P-glycoprotein in ormal human tissues. Proc Natl Acad Sci U S A 1987;84:7735-8.
2. Hunter J, Jepson MA, Tsuruo T, Simmons NL, Hirst BH. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. J Biol Chem 1993; 268:14991-7.
3. Cordon-Cardo C, O'Brien JP, Casals D. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci U S A 1989;86: 695-8.
4. Goldstein LJ. MDR1 gene expression in solid tumor. Eur J Cancer 1996;32:1039-50.
5. Silverman JA, Schrenk D. Expression of multidrug resistance genes in liver. FASEB J 1997;11:308-13.
6. Becker KF, Allmeier H, Hollt V. New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones? Horm Metab Res 1992;24:210-3.
7. Schinkel AH, Smit, JJM, Vantelli O, Beilnen JH, Wagenaar EC, Riele HPJ, et al. Disruption of the mouse mdr 1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994;77: 491-502.
8. Kiehntopf M, Brach MA, Licht T, Petschauer S, Karawajew L, Kirschning C, et al. Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells. EMBO J 1994;13:4645-52.
9. Watt G, Long GW, Grogl M, Martin SK. Reversal of drug-resistant falciparum malaria by calcium antagonists: potential for host cell toxicity. Trans R Soc Trop Med Hyg 1990;84: 187-90.
10. Chaudy PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991;66:85-94.
11. Sun D, Abraham SN, Beachey EH. Influence of berberine sulfate on synthesis and expression of Pap fimbrial adhesion in uropathogenic Escherichia coli. Antimicrob Agents Chemother 1988;32:1370-4.
12. Jenning BR, Ridler PJ. Interaction of chromosomal stains with DNA: an electrofluorescence study. Biophys Struct Mech 1983;10:71-9.
13. Taira Z, Matsumoto M, Ishida S, Ichikawa T, Sakiya Y. Aggregation of DNA enhanced by protoberberine alkaloids, coralyne and berberine. Chem Pharmacol Bull 1994;42: 1556-61.
14. Kuo CL, Chou CC, Yung YM. Berberine complex with DNA in the berberine-induced apoptosis in human leukemia HL-60 cells. Cancer Lett 1995;93:193-200.
15. Chi CW, Chang YF, Chao TW, Chiang SH. P'eng FK, Lui WY, et al. Flow cytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. Life Sci 1994;45:2099-107.
16. Ueda K, Pastan I, Gottesman MM. Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem 1987;262:17432-6.
17. Petriz J, Garcia-Lopez J. Flow cytometric analysis of P-glycoprotein function using rhodamine 123. Leukemia 1997;11: 1124-30.
18. Ludescher C, Thaler J, Drach D, Drach J, Spitaler M, Gattringer C, et al. Detection of activity of P-glycoprotein in human tumor samples using rhodamine 123. Br J Haematol 1992;82:161-8.
19. Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess DY changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 1997;411:77-82.
20. Wang YX, Zheng YM. Ionic mechanism responsible for prolongation of cardiac action-potential duration by berberine. J Cardiovasc Pharmacol 1997;30:214-22.
21. Wang YX, Zheng YM, Zhou XB. Inhibitory effects of berberine on ATP-sensitive K+ channels in cardiac myocytes. Eur J Pharmacol 1996;316:307-15.
22. Ivanovska N, Philipov S. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 1996;18:553-61.
23. Ckless K, Schlottfeldt JL, Pasqual M, Moyna P, Henriques JA, Wajner M. Inhibition of in-vitro lymphocyte transformation by the isoquinoline alkaloid berberine. J Pharm Pharmacol 1995;47:1029-31.
24. Miura N, Yamamoto M, Ueki T, Kitani T, Fukuda K, Komatsu Y. Inhibition of thymocyte apoptosis by berberine. Biochem Pharmacol 1997;53:1315-22.
25. Ikekawa T, Ikeda Y. Antitumor activity of 13-methyl-berberrubine derivatives. J Pharmacobiodyn 1982;5:469-74.
26. Zhang RX, Dougherty DV, Rosenblum ML. Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. Chin Med J 1990;103:658-65.
27. Chen KT, Hao DM, Liu ZX, Chen YC, You ZS. Effect of berberine alone or in combination with argon ion laser treatment on 9L rat glioma cell line. Chin Med J 1994;107: 808-12.
28. Bellamy WT. P-glycoproteins and multidrug resistance. Ann Rev Pharmacol Taxicol 1996;36:161-83.
29. Bates SE, Mickley LA, Chen Y, Richert N, Rudick J, Biedler J, et al. Expression of drug resistance gene in human neuroblastoma cell lines: modulation by retioic acid-induced differentiation. Mol Cell Biol 1989;9:4337-44.
30. Chin K, Tanaka S, Darligton G, Pastan I, Gottesman MM. Heat shock and arsenite increases expression of multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem 1990;265:221-6.
31. Fairchild CR, Ivy SP, Rushmore T, Lee G, Koo P, Goldsmith ME, et al. Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinoma. Proc Natl Acad Sci U S A 1987;84:7701-5.
32. Kohno K, Sato S, Takano H, Matsuo K, Kuwano M. The direct activation of human multidrug resistance gene (MDR1) by anticancer agents. Biochem Biophys Res Commun 1989;165:1415-21.
33. Chen ZS, Mutoh M, Sumizawa T, Furukawa T, Haraguchi M, Tani A, et al. An efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Exp Cell Res 1998;240: 312-20.
34. Szabo K, Bakos E, Welker E, Muller M, Goodfellow HR, Higgins CF, et al. Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity. J Biol Chem 1997;272:23165-71.
35. Chen CM, Chang HC. Determination of berberine in plasma, urine and bile by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1995;665:117-23.
36. Miyazaki H, Shirai E, Ishibashi M, Niizima K. Quantitative analysis of berberine in urine samples by chemical ionization mass fragmentography. J Chromatogr 1978;152: 79-86.