Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication

Atherosclerosis

Volumn 165, Issue 2, 2002, Pages 277-283

  Silvestro, Antonio ^a,c   Scopacasa, Francesco ^a   Oliva, Gabriella ^a   De Cristofaro, Tiziana ^a   Iuliano, Luigi ^b   Brevetti, Gregorio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NONE   (Italy)

Author keywords

Adhesion molecules; Endothelium dysfunction; Exercise; Intermittent claudication; Vitamin C

Indexed keywords

ASCORBIC ACID; INTERCELLULAR ADHESION MOLECULE 1; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIOXIDANT;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM LESION; EXERCISE; FEMALE; HUMAN; INTERMITTENT CLAUDICATION; MALE; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOLUBILITY; BLOOD; BRACHIAL ARTERY; EXERCISE TEST; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PHYSIOLOGY; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASODILATATION;

ANTIOXIDANTS; ASCORBIC ACID; BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERMITTENT CLAUDICATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; TREATMENT OUTCOME; VASODILATION;

EID: 0036889640     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(02)00235-6     Document Type: Article

References (40)

1. Belch J.J., Mackay I.R., Hill A., Jennings P., McCollum P. Oxidative stress is present in atherosclerotic peripheral artery disease and further increased by diabetes mellitus. Int. Angiol. 14:1995;385-388.
2. Neumann F.J., Waas W., Diehm C. Activation and decreased deformability of neutrophils after intermittent claudication. Circulation. 82:1990;922-929.
3. Khaira H.S., Nash G.B., Bohra P.S., Sanghera K., Gosling P., Crow A.J., Shearman C.P. Thromboxane and neutrophil changes following intermittent claudication suggest ischemia-reperfusion injury. Eur. J. Vasc. Endovasc. Surg. 10:1995;31-35.
4. Kirk G., Hickman P., McLaren M., Stonebridge P.A., Belch J.J. Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease. Eur. J. Vasc. Endovasc. Surg. 18:1999;434-438.
5. Iwata H., Matsushita M., Nishikimi N., Sakwai T., Nimura Y. Intestinal permeability is increased in patients with intermittent claudication. J. Vasc. Surg. 31:2000;1003-1007.
6. Hickey N.C., Shearman C.P., Gosling P., Simms M.A. Assessment of intermittent claudication by quantitation of exercise-induced microalbuminuria. Eur. J. Vasc. Surg. 4:1990;601-606.
7. Neunteufl T., Priglinger U., Heher S. Effects of vitamin E on chronic and acute endothelial dysfunction in smokers. J. Am. Coll. Cardiol. 35:2000;277-283.
8. Kanani P.M., Sinkey C.A., Browning R.I., Allaman M., Knapp H.R., Haynes W.C. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation. 100:(11):1999;1161-1168.
9. Title L.M., Cummings P.M., Giddens K., Nassar B.A. Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J. Am. Coll. Cardiol. 36:2000;2185-2191.
10. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., Mitchinson M.J. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet. 347:1996;781-786.
11. Boaz M., Smetana S., Weinstein T. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet. 356:2000;1213-1218.
12. GISSI-Prevenzione Investigators . Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione Trial. Lancet. 354:1999;447-455.
13. The Heart Outcomes Prevention Evaluation Study Investigators . Vitamin E supplementation and cardiovascular events in high risk patients. N. Engl. J. Med. 342:2000;154-160.
14. Esterrbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 186c:1990;407.
15. Yataco A.R., Corretti M.C., Gardner A.W., Womack C.J., Katzel L.I. Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease. Am. J. Cardiol. 83:1999;754-758.
16. Brevetti G., Martone V.D., de Cristoforo T. High levels of adhesion molecules are associated with impaired endothelium-dependent vasodilation in patients with peripheral arterial disease. Thromb. Haemost. 85:2001;63-66.
17. Joannides R., Haefeli W.E., Linder L., Richard V., Bakkali E.H., Thuillez C., Luscher T.F. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo. Circulation. 9:1995;1314-1319.
18. Anderson T.J., Uehata A., Gerhard M.D. Close relation of endothelial function in the human coronary and peripheral circulations. J. Am. Coll. Cardiol. 26:1995;1235-1241.
19. Celermajer D.S., Sorensen K.E., Bull C., Robinson J., Deanfield J.E. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects related to coronary risk factors and their interaction. J. Am. Coll. Cardiol. 24:1994;1468-1474.
20. Perticone F., Ceravolo R., Pujia A. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 104:2001;191-196.
21. Vallance P., Collier J., Bhagat K. Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link? Lancet. 349:1997;1391-1392.
22. Ross R. Atherosclerosis. An inflammatory disease. N. Engl. J. Med. 340:1999;115-126.
23. Criqui M.H., Langer R.D., Fronek A., Feigelson H.S., Klauber M.R., McCann T.J., Browner D. Mortality over a period of 10 years in patients with peripheral arterial disease. N. Engl. J. Med. 326:1992;381-386.
24. Bainton D., Sweetnam P., Baker I., Elwood P. Peripheral vascular disease: consequence for survival and association with risk factors in the Speedwell prospective heart disease study. Br. Heart J. 72:1994;128-132.
25. Brevetti G., De Caterina M., Martone V.D. Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication. Clin. Hemorheol. Microcirc. 24:2001;193-199.
26. Murohara T., Kugiyama K., Ohgushi M., Sugiyama S., Yasne H. Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF. Am. J. Physiol. 266:1994;H874-880.
27. Radomski M.W., Salas E. Nitric oxide - biological mediator, modulator and factor of injury: its role in the pathogenesis of atherosclerosis. Atherosclerosis. (Suppl. 118):1995;S69-S80.
28. Jackson T.S., Xu A., Vita J.A., Keaney J.F. Jr. Ascorbate prevents the interaction of superoxide and nitric oxide only at high physiological concentration. Circ. Res. 83:1998;916-922.
29. Frei B., England L., Ames B.N. Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl. Acad. Sci. USA. 86:1989;6377-6381.
30. Wetzstein C.J., Shern-Brewer R.A., Santanam N., Green N.R., White-Welkley J.E., Parthasarathy S. Does acute exercise affect the susceptibility of low density lipoprotein to oxidation? Free Radic. Biol. Med. 24:1998;679-682.
31. Diaz M.N., Frei B., Vita J.A., Keaney J.F. Jr. Antioxidant and atherosclerotic heart disease. N. Engl. J. Med. 337:1997;408-417.
32. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J. Biol. Chem. 269:1994;9397-9400.
33. Langlois M., Duprez D., Delanghe J., De Buyzere M., Clement D.L. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation. 103:2001;1863-1868.
34. Blann A.D., McCollum C.N. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb. Haemost. 72:1994;151-154.
35. Hamilton C.A., Brosnan M.J., McIntyre M., Graham D., Dominiczak A.F. Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension. 37:2001;529-534.
36. Guzik T.J., West N.E.J., Black E., McDonald D., Ratnatunga C., Pillai R., Channon K.M. Vascular superoxide production by NAD(P)H oxidase. Association with endothelial dysfunction and clinical risk factors. Circ. Res. 86:2000;e85-e90.
37. Gokce N., Keaney J.F. Jr., Vita J.A. Endotheliopathies clinical manifestation of endothelial dysfunction. Loscalzo J., Shafer A.I., Thrombosis and Haemorrhage. 2nd ed. 1998;901-924 Williams & Wilkins, Baltimore, MD.
38. Bergholm R., Makimattila S., Valkonen M. Intense physical training decreases circulating antioxidant and endothelium-dependent vasodilation in vivo. Atherosclerosis. 145:1999;341-349.
39. Turton E.P., Coughlin P.A., Kester R.C., Scott D.J. Exercise training reduces the acute inflammatory response associated with claudication. Eur. J. Vasc. Endovasc. Surg. 23:2002;309-316.
40. Brendle D.C., Joseph L.J.O., Corretti M.C., Gadner A.W., Katzel L.I. Effect of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease. Am. J. Cardiol. 87:2001;324-329.