Exercise training reduces the acute inflammatory response associated with claudication

European Journal of Vascular and Endovascular Surgery

Volumn 23, Issue 4, 2002, Pages 309-316

  Turton, E P L ^a,b   Coughlin, P A ^a   Kester, R C ^a   Scott, D J A ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b Ash House   (United Kingdom)

Author keywords

Exercise therapy; Inflammation; Intermittent claudication

Indexed keywords

ANTIOXIDANT; FREE RADICAL; LEUKOCYTE ELASTASE;

ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRANULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; FLOW CYTOMETRY; HUMAN; INFLAMMATION; INTERMITTENT CLAUDICATION; ISCHEMIA; LEUKOCYTE ACTIVATION; LIPID PEROXIDATION; MALE; PRIORITY JOURNAL; REPERFUSION INJURY; TREADMILL EXERCISE; VASCULAR ENDOTHELIUM; WALKING; ANALYSIS OF VARIANCE; BLOOD; CASE CONTROL STUDY; INJURY; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIOXIDANTS; CASE-CONTROL STUDIES; CHEMILUMINESCENT MEASUREMENTS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; INTERMITTENT CLAUDICATION; LEUKOCYTE ELASTASE; LIPID PEROXIDATION; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; REPERFUSION INJURY; STATISTICS, NONPARAMETRIC; WALKING;

EID: 0036550585     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1053/ejvs.2002.1599     Document Type: Article

References (24)

1. RIDKER PM, CUSHMAN M, STAMPFER MJ, TRACY RP, HENNEKENS CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-979.
2. DORMANDY JA, MURRAY GD. The fate of the claudicant - a prospective study of 1969 claudicants. Eur J Vasc Surg 1991; 5: 131-133.
3. GRIMM RH JR, NEATON JD, LUDWIG W. Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality. JAMA 1985; 254: 1932-1937.
4. HAVERKATE F, THOMPSON SG, DUCKERT F. Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. Thrombosis & Haemostasis 1995; 73: 561-567.
5. NEUMANN FJ, WAAS W, DIEHM C et al. Activation and decreased deformability of neutrophils after intermittent claudication. Circulation 1990; 82: 922-929.
6. HICKMAN P, HARRISON DK, HILL A et al. Exercise in patients with intermittent claudication results in the generation of oxygen derived free radicals and endothelial damage. Adv Exp Med Biol 1994; 361: 565-570.
7. KIRK G, HICKMAN P, MCLAREN M, STONEBRIDGE PA, BELCH JJ. Interleukin-8 (IL-8) may contribute to the activation of neutrophils in patients with peripheral arterial occlusive disease (PAOD). Eur J Vasc Endovasc Surg 1999; 18: 434-438.
8. SHEARMAN CP, GOSLING P, GWYNN BR, SIMMS MH. Systemic effects associated with intermittent claudication. A model to study biochemical aspects of vascular disease? Eur J Vasc Surg 1988; 2: 401-404.
9. TURTON EP, SPARK JI, MERCER KG et al. Exercise-induced neutrophil activation in claudicants: a physiological or pathological response to exhaustive exercise? Eur J Vasc Endovasc Surg 1998; 16: 192-196.
10. KHAIRA HS, MAXWELL SR, SHEARMAN CP. Antioxidant consumption during exercise in intermittent claudication. Br J Surg 1995; 82: 1660-1662.
11. KHAIRA HS, NASH GB, BAHRA PS et al. Thromboxane and neutrophil changes following intermittent claudication suggest ischaemia-reperfusion injury. Eur J Vasc Endovasc Surg 1995; 10: 31-35.
12. TISI PV, HULSE M, CHULAKADABBA A, GOSLING P, SHEARMAN CP. Exercise training for intermittent claudication: does it adversely affect biochemical markers of the exercise-induced inflammatory response? Eur J Vasc Endovasc Surg 1997; 14: 344-350.
13. TISI PV, SHEARMAN CP. The evidence for exercise-induced inflammation in intermittent claudication: should we encourage patients to stop walking? Eur J Vasc Endovasc Surg 1998; 15: 7-17.
14. TISI PV, SHEARMAN CP. Biochemical and inflammatory changes in the exercising claudicant. Vasc Med 1998; 3: 189-198.
15. GARDNER AW, POEHLMAN ET. Exercise rehabilitation programs for the treatment of claudication pain. A meta-analysis. JAMA 1995; 274: 975-980.
16. TAN KH, COTTERRELL D, SYKES K et al. Exercise training for claudicants: changes in blood flow, cardiorespiratory status, metabolic functions, blood rheology and lipid profile. Eur J Vasc Endovasc Surg 2000; 20: 72-78.
17. HIATT WR, REGENSTEINER JG, WOLFEL EE, CARRY MR, BRASS EP. Effect of exercise training on skeletal muscle histology and metabolism in peripheral arterial disease. J Appl Physiol 1996; 81: 780-788.
18. ERNST EE, MATRAI A. Intermittent claudication, exercise, and blood rheology. Circulation 1987; 76: 1110-1114.
19. MAXWELL SR, THORPE GH, WHITEHEAD TP. An enhanced chemiluminescent assay for antioxidant capacity in biological fluids. Annal Chim Acta 1992; 266: 265-277.
20. ROBEER GG, BRANDSMA JW, VAN DEN HEUVEL SP et al. Exercise therapy for intermittent claudication: a review of the quality of randomised clinical trials and evaluation of predictive factors. Eur J Vasc Endovasc Surg 1998; 15: 36-43.
21. REMIJNSE-TAMERIUS HC, DUPREZ D, DE BUYZERE M, OESEBURG B, CLEMENT DL. Why is training effective in the treatment of patients with intermittent claudication? Int Angiol 1999; 18: 103-112.
22. ERNST E. Influence of regular physical activity on blood rheology. Eur Heart J 1987; 8 (Suppl. G): 59-62.
23. RUELL PA, IMPERIAL ES, BONAR FJ, THURSBY PF, GASS GC. Intermittent claudication. The effect of physical training on walking tolerance and venous lactate concentration. Eur J Appl Physiol Occupational Physiol 1984; 52: 420-425.
24. LUNDGREN F, DAHLLOF AG, SCHERSTEN T, BYLUND-FELLENIUS AC. Muscle enzyme adaptation in patients with peripheral arterial insufficiency: spontaneous adaptation, effect of different treatments and consequences on walking performance. Clin Sci 1989; 77: 485-493.