Regulation of xanthine oxidoreductase by intracellular iron

American Journal of Physiology - Cell Physiology

Volumn 283, Issue 6 52-6, 2002, Pages

  Martelin, Eeva ^a,b   Lapatto, Risto ^a   Raivio, Kari O ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Deferoxamine; Gene regulation; Iron sulfur proteins; Ischemia reperfusion injury; Reactive oxygen species

Indexed keywords

DEFEROXAMINE; FERRIC AMMONIUM CITRATE; FERROUS SULFATE; IRON; IRON SULFUR PROTEIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

ANIMAL CELL; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; HUMAN; HUMAN CELL; IRON CHELATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RNA ANALYSIS;

ANIMALIA; BRONCHUS; LETHRINIDAE;

EID: 0036889054     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00280.2002     Document Type: Article

References (43)

1. Alcantara O, Kalidas M, Baltathakis I, and Boldt DH. Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron. Exp Hematol 29: 1060-1069, 2001.
2. Alcantara O, Obeid L, Hannun Y, Ponka P, and Boldt DH. Regulation of protein kinase C (PKC) expression by iron: Effect of different iron compounds on PKC-β and PKC-α gene expression and role of the 5′-flanking region of the PKC-β gene in the response to ferric transferrin. Blood 84: 3510-3517, 1994.
3. 2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin. J Biol Chem 265: 14170-14175, 1990.
4. Brenneisen P, Wenk J, Klotz LO, Wlaschek M, Briviba K, Krieg T, Sies H, and Scharffetter-Kochanek K. Central role of ferrous/ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts. J Biol Chem 273: 5279-5287, 1998.
5. Chan PH. Role of oxidants in ischemic brain damage. Stroke 27: 1124-1129, 1996.
6. Chi SI, Wang CK, Chen JJ, Chau LY, and Lin TN. Differential regulation of H- and L-ferritin messenger RNA subunits, ferritin protein and iron following focal cerebral ischemia-reperfusion. Neuroscience 100: 475-484, 2000.
7. Chow CW, Clark MP, Rinaldo JE, and Chalkley R. Multiple initiators and C/EBP binding sites are involved in transcription from the TATA-less rat XDH/XO basal promoter. Nucleic Acids Res 23: 3132-3140, 1995.
8. Clark MP, Chow CW, Rinaldo JE, and Chalkley R. Correct usage of multiple transcription initiation sites and C/EBP-dependent transcription activation of the rat XDH/XO TATA-less promoter requires downstream elements located in the coding region of the gene. Nucleic Acids Res 26: 1801-1806, 1998.
9. Cooper CE, Lynagh GR, Hoyes KP, Hider RC, Cammack R, and Porter JB. The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J Biol Chem 271: 20291-20299, 1996.
10. Davalos A, Castillo J, Marrugat J, Fernandez-Real JM, Armengou A, Cacabelos P, and Rama R. Body iron stores and early neurologic deterioration in acute cerebral infarction. Neurology 54: 1568-1574, 2000.
11. De Valk B and Marx JJM. Iron, atherosclerosis, and ischemic heart disease. Arch Intern Med 159: 1542-1548, 1999.
12. Dlaska M and Weiss G. Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. J Immunol 162: 6171-6177, 1999.
13. Duffy SJ, Biegelsen ES, Holbrook M, Russell JD, Gokce N, Keaney JF, and Vita JA. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation 103:2799-2804, 2001.
14. Dupont GP, Huecksteadt TP, Marshall BC, Ryan US, Michael JR, and Hoidal JR. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest 89: 197-202, 1992.
15. Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr 20: 627-662, 2000.
16. Falciani F, Ghezzi P, Terao M, Cazzaniga G, and Garattini E. Interferons induce xanthine dehydrogenase gene expression in L929 cells. Biochem J 285: 1001-1008, 1992.
17. Gray NK, Pantopoulous K, Dandekar T, Ackrell BA, and Hentze MW. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc Natl Acad Sci USA 93: 4925-4930, 1996.
18. Halliwell B and Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford, UK: Oxford University Press, 1999.
19. Hassoun PM, Yu FS, Shedd AL, Zulueta JJ, Thannickal VJ, Lanzillo JJ, and Fanburg BL. Regulation of endothelial cell xanthine dehydrogenase/xanthine oxidase gene expression by oxygen tension. Am J Physiol Lung Cell Mol Physiol 266: L163-L171, 1994.
20. Hille R and Nishino T. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 9: 995-1003, 1995.
21. Huang YT, Ghio AJ, Nozik-Grayck E, and Piantadosi CA. Vascular release of nonheme iron in perfused rabbit lungs. Am J Physiol Lung Cell Mol Physiol 280: L474-L481, 2001.
22. Kim HY, LaVaute T, Iwai K, Klausner RD, and Rouault TA. Identification of a conserved and functional iron-responsive element in the 5′-untranslated region of mammalian mitochondrial aconitase. J Biol Chem 271: 24226-24230, 1996.
23. Klausner RD, Rouault TA, and Harford JB. Regulating the fate of mRNA: The control of cellular iron metabolism. Cell 72: 19-28, 1993.
24. Kooij A. A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase. Histochem J 26: 889-915, 1994.
25. Lin M, Rippe RA, Niemela O, Brittenham G, and Tsukamoto H. Role of iron in NF-κB activation and cytokine gene expression by rat hepatic macrophages. Am J Physiol Gastrointest Liver Physiol 272: G1355-G1364, 1997.
26. Linder N, Rapola J, and Raivio KO. Cellular expression of xanthine oxidoreductase protein in normal human tissues. Lab Invest 79: 967-974, 1999.
27. Martelin E, Palvimo JJ, Lapatto R, and Raivio KO. Nuclear factor Y activates the human xanthine oxidoreductase gene promoter. FEBS Lett 480: 84-88, 2000.
28. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312: 159-163, 1985.
29. Nishino T. The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury. J Biochem (Tokyo) 116: 1-6, 1994.
30. Nishino T and Okamoto K. The role of the [2Fe-2s] cluster centers in xanthine oxidoreductase. J Inorg Biochem 82: 43-49, 2000.
31. Pfeffer KD, Huecksteadt TP, and Hoidal JR. Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation. J Immunol 153: 1789-1797, 1994.
32. Poss WB, Huecksteadt TP, Panus PC, Freeman BA, and Hoidal JR. Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia. Am J Physiol Lung Cell Mol Physiol 270: L941-L946, 1996.
33. Richardson DR and Ponka P. Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism. Am J Hematol 58: 299-305, 1998.
34. Rinaldo JE and Gorry M. Protection by deferoxamine from endothelial injury: A possible link with inhibition of intracellular xanthine oxidase. Am J Respir Cell Mol Biol 3: 525-533, 1990.
35. Saksela M, Lapatto R, and Raivio KO. Xanthine oxidoreductase gene expression and enzyme activity in developing human tissues. Biol Neonate 74: 274-280, 1998.
36. Saksela M and Raivio KO. Cloning and expression in vitro of human xanthine dehydrogenase/oxidase. Biochem J 315: 235-239, 1996.
37. Sambrook J, Fritsch EF, and Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
38. Sarnesto A, Linder N, and Raivio KO. Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein. Lab Invest 74: 48-56, 1996.
39. Schreck R, Rieber P, and Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 10:2247-2258, 1991.
40. Siesjo BK, Bendek G, Koide T, Westerberg E, and Wieloch T. Influence of acidosis on lipid peroxidation in brain tissues in vitro. J Cereb Blood Flow Metab 5: 253-258, 1985.
41. Stevens CR, Millar TM, Clinch JG, Kanczler JM, Bodamyali T, and Blake DR. Antibacterial properties of xanthine oxidase in human milk. Lancet 356: 829-830, 2000.
42. Xu P, Huecksteadt TP, and Hoidal JR. Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics 34: 173-180, 1996.
43. Ye Z and Connor JR. Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions. Nucleic Acids Res 28: 1802-1807, 2000.