Synthesis of 4-alkyl-1,2-diphenyl-3,5-dioxopyrazolidines possessing aryl methylsulfonyl and sulfonamide pharmacophores for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors

Journal of Heterocyclic Chemistry

Volumn 39, Issue 6, 2002, Pages 1309-1314

  Rahim, M Abdur ^a   Rao, P N Praveen ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIPHENYL 3,5 PYRAZOLIDINEDIONE DERIVATIVE; 1,2 DIPHENYLHYDRAZINE; 4 N BUTYL 1 (4 METHYLSULFONYLPHENYL) 2 (4 FLUOROPHENYL) 3,5 DIOXOPYRAZOLIDINE; 4 N BUTYL 1 (4 METHYLSULFONYLPHENYL) 2 (4 TOLYL) 3,5 DIOXOPYRAZOLIDINE; 4 N BUTYL 1 (4 METHYLSULFONYLPHENYL) 2 PHENYL 3,5 DIOXOPYRAZOLIDINE; AMMONIUM CHLORIDE; ANILINE DERIVATIVE; AZOBENZENE DERIVATIVE; BENZENE DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; CYCLOPROPANE DERIVATIVE; FLUORINE DERIVATIVE; HYDROGEN; MELOXICAM; MESYLIC ACID DERIVATIVE; METHYL GROUP; NITROSOBENZENE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE; ROFECOXIB; SULFONAMIDE; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; HUMAN; MALE; NONHUMAN; PHARMACOPHORE; POLYMERIZATION; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0036875608     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570390631     Document Type: Article

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