Alternative splicing in the brain of mice and rats generates transferrin transcripts lacking, as in humans, the signal peptide sequence

Neurochemical Research

Volumn 27, Issue 11, 2002, Pages 1459-1463

  Duchange, Nathalie ^a   Saleh, Marla Carla ^a   De Arriba Zerpa, Gonzalo ^a   Pidoux, Josette ^a   Guillou, Florian ^a   Zakin, Mario M ^a   Baron, Bruno ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Brain; Evolution; Homology; Signal peptide; Splicing; Transferrin

Indexed keywords

SIGNAL PEPTIDE; TRANSFERRIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; EXON; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SERUM; SPECIES DIFFERENCE;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; DNA PRIMERS; HUMANS; MICE; PROTEIN SORTING SIGNALS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSFERRIN;

ANIMALIA; VERTEBRATA;

EID: 0036865646     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021692220482     Document Type: Article

References (14)

1. de Jong, G., van Dijk, J. P., and van Eijk, H. G. 1990. The biology of transferrin. Clin. Chim. Acta 190:1-46.
2. Skinner, M. K. and Griswold, M. D. 1980. Sertoli cells synthesize and secrete transferrin-like protein. J. Biol. Chem. 255:9523-9525.
3. Bloch, B., Popovici, T., Levin, M. J., Tuil, D., and Kahn, A. 1985. Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry. Proc. Natl. Acad. Sci. U.S.A. 82:6706-6710.
4. de Arriba Zerpa, G. A., Saleh, M. C., Fernandez, P. M., Guillou, F., Espinosa De Los Monteros, A., de Vellis, J., Zakin, M. M., and Baron, B. 2000. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. J. Neurosci. Res. 61:388-395.
5. Saito, Y., Maruyama, K., Saido, T. C., and Kawashima, S. 1997. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells. J. Neurosci. Res. 48:397-406.
6. Arjomand. J. and Evans, C. J. 2001. Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor. J. Neurochem. 77:720-729.
7. Kenyon, J. R. and Craig, I. W. 1999. Analysis of the 5′ regulatory region of the human Norrie's disease gene: Evidence that a non-translated CT dinucleotide repeat in exon one has a role in controlling expression. Gene 227:181-188.
8. Guillou, F., Zakin, M. M., Part, D., Boissier, F., and Schaeffer, E. 1991. Sertoli cell-specific expression of the human transferrin gene. Comparison with the liver-specific expression. J. Biol. Chem. 266:9876-9884.
9. Brunel, F., Ochoa, A., Schaeffer, E., Boissier, F., Guillou, Y., Cereghini, S., Cohen, G. N., and Zakin, M. M. 1988. Interactions of DNA-binding proteins with the 5′ region of the human transferrin gene. J. Biol. Chem. 263:10180-10185.
10. Terenzi, H., Alzari, P. M., and Zakin, M. M. 1998. Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites. Biochemistry 37:11488-11495.
11. Modrek, B. and Lee, C. 2002. A genomic view of alternative splicing. Nat. Genet. 30:13-19.
12. Modrek, B., Resch, A., Grasso, C., and Lee, C. 2001. Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res. 29:2850-2859.
13. Marta, C. B., Escobar, Cabrera, O. E., Garcia, C. I., Villar, M. J., Pasquini, J. M., and Soto, E. F, 2000. Oligodendroglial cell differentiation in rat brain is accelerated by the intracranial injection of apotransferrin. Cell. Mol. Biol. (Noisy-le-grand) 46:529-539.
14. Espinosa de los Monteros, A., Kumar, S., Zhao, P., Huang, C. J. Nazarian, R., Pan, T., Scully, S., Chang, R., and de Vellis, J. 1999. Transferrin is an essential factor for myelination. Neurochem. Res. 24:235-248.