Recent progress in understanding the relationships among aging, replicative senescence, cell turnover and cancer

In Vivo

Volumn 16, Issue 6, 2002, Pages 393-396

  Warner, Huber R ^a  

^a National Institute of Aging   (United States)

Author keywords

Aging; Cancer; Cell turnover; Mutations; Replicative senescence

Indexed keywords

BETA GALACTOSIDASE; BINDING PROTEIN; GENE PRODUCT; HISTONE DEACETYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN P53; TANKYRASE; SIRTUIN;

AGING; APOPTOSIS; BYSTANDER EFFECT; CANCER; CANCER RESEARCH; CARCINOGENESIS; CELL AGING; CELL CULTURE; CELL DAMAGE; CELL PROLIFERATION; DEGRADATION; DNA DAMAGE; DNA METABOLISM; DNA REPLICATION; ENZYME ACTIVITY; EVIDENCE BASED MEDICINE; EXPERIMENTATION; FIBROBLAST; GENE ACTIVITY; GROWTH DISORDER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INVERTEBRATE; LIFE EXPECTANCY; LONGEVITY; MAMMAL; MICROENVIRONMENT; MUTATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTEIN FUNCTION; REVIEW; SENESCENCE; SKIN BIOPSY; STEM CELL; TELOMERE; TUMOR SUPPRESSOR GENE; CELL DIVISION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY;

AGING; CELL AGING; CELL DIVISION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, P53; HUMANS; NEOPLASMS; SIRTUINS;

EID: 0036865246     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636, 1965.
2. Martin GM, Sprague CA and Epstein CJ: Replicative life-span of cultivated human cells. Effects of donor's age, tissue and genotype. Lab Invest 23: 86-92, 1970.
3. Cnistofalo VJ, Allen RG, Pignolo RJ, Martin BG and Beck JC: Relationship between donor age and replicative lifespan of human cells in culture: A re-evaluation. Proc Nat Acad Sci USA 95: 10614-10619, 1998.
4. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith 0, Peacocke M and Campisi J: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
5. Allsop RC, Chang E, Kashefi-Aazam M, Rogaev El, Piatyszek MA, Shay JW and Harley CB: Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 220: 194-200, 1995.
6. Campisi J, Kim S-H, Lim C-S and Rubio M: Cellular senescence, cancer and aging: The telomere connection. Exp Gerontol 36: 1619-1637 2001.
7. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chin CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE: Extension of life span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998.
8. Blackburn EH: Telomere states and cell fates. Nature 408: 53-56, 2000.
9. De Lange T: Telomere capping-one strand fits all. Science 292: 1075-1076, 2001.
10. Broccoli D, Smorgorzewska A, Chong L and De Lange T: Human telomeres contain two distinct Myb-like proteins, TRF1 and TRF2. Nature Genet 1997; 17: 231-235, 1997.
11. Hsu HL, Gilley D, Blackburn EH and Chen DJ: Ku is associated with the telomere in mammals. Proc. Natl. Acad. Sci. USA 96: 12454-12458, 1999.
12. Kim SH, Kaminker P and Campisi J: Tin2, a new regulator of telomere length in human cells. Nature Genet 23: 405-412, 1999.
13. Smith S, Giriat I, Schmitt A and De Lange T: Tankyrase, a poly (ADP-ribose) polymerase at human telomeres. Science 282: 1484-1487, 1998.
14. Chen QM, Prowse KR, Tu VC, Purdom S and Linskens MH: Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp Cell Res 265: 294-303, 2001.
15. Serrano M, Lin AW, McCurrah ME, Beach D and Lowe SW: Orcogenic ras provokes INK4a premature cell senescence associated with accumulation of p53 and p16 Cell 88: 593-602, 1997.
16. Campisi J: Replicative senescence: An old live's tale? Cell 84: 497-500, 1996.
17. Campisi J: Aging and cancer: The double-edged sword of replicative senescence. J Am Geriat Soc 45: 482-488, 1997.
18. Campisi J: The biology of replicative senescence. Eur J Cancer 33: 703-709, 1997.
19. Campisi J: Cellular senescence as a tumor-suppressor mechanisms. Trends Cel Biol 11: 527-537, 2001.
20. Millis AJ, Hoyle M, McCue HM and Martini H: Differential expression of metaloproteinase and tissue inhibitor of metalloprotemase genes in aged human firoblasts. Exp Cell Res 201: 373-379, 1992.
21. Lochter A and Bissell MJ: Involvement of extracellular matrix constituents in breast cancer. Sem Cancer Biol 6: 165-173, 1995
22. Krtolica A, Parrinello S, Lockett S, Desprez P-Y and Campisi J: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 98: 12072-12077, 2001.
23. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
24. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Jr, Butel JS and Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-221, 1992.
25. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Park SH, Thompson T, Karsenty G, Bradley A and Donehower LA: p53 mutant mice that display early ageing-associated phenotypes. Nature 415: 45-53, 2002.
26. Warner HR: Apoptosis: A two-sword in aging. Anticancer Res 16: 2837-2842, 1999.
27. Lin S-J, Defossez P-A and Guarente L: Requirement of NAD and SIR2 for life-span extension by caloric restriction in Saccharomyces cerevisiae. Science 289: 2126-2128, 2000.
28. Tissenbaum HA and Guarente L: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001.
29. Luo J, Nikolaev AY, Imal S, Chen D, Su F, Shiloh A, Guarente L and Gu W: Negative control of p53 by sir2 alpha promotes cell survival under stress. Cell 107: 137-148, 2001.
30. Ferbeyre G and Lowe SW: The price of tumor suppression? Nature 415: 26-27, 2002.