Increased sensitivity of the obese Zucker rat to deoxycorticosterone-salt-induced hypertension

Journal of Hypertension

Volumn 20, Issue 11, 2002, Pages 2247-2255

  Morrison, Ryan G ^a   Carpenter, A Betts ^a   Moore, Stephany K ^a   Mangiarua, Elsa I ^a   Valentovic, Monica A ^a   Walker Jr , Ernest M ^a   Wehner, Paulette S ^a   Rhoten, William B ^a   Touchon, Robert C ^a   McCumbee, William D ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Deoxycorticosterone acetate; Hypertension; Kidney; Obese Zucker rat; Obesity associated hypertension

Indexed keywords

ALBUMIN; DEOXYCORTICOSTERONE ACETATE; SODIUM CHLORIDE; DEOXYCORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLOMERULOSCLEROSIS; HISTOLOGY; HYPERTENSION; INTERSTITIAL NEPHRITIS; NEPHRECTOMY; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEINURIA; RAT; RAT STRAIN; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DISEASE PREDISPOSITION; GLOMERULUS; PATHOLOGY; RENOVASCULAR HYPERTENSION; SALT INTAKE; ZUCKER RAT;

ANIMALS; BLOOD PRESSURE; DESOXYCORTICOSTERONE; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; HYPERTENSION, RENAL; KIDNEY GLOMERULUS; NEPHRECTOMY; OBESITY; RATS; RATS, ZUCKER; RISK FACTORS; SODIUM CHLORIDE, DIETARY;

EID: 0036855764     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200211000-00025     Document Type: Article

References (40)

1. Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 1993; 119:655-660.
2. World Health Organization. Obesity: Preventing and managing the global epidemic. Geneva: World Health Organization; 2000. World Health Organization Technical Report Series; 894.
3. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults: The National Health and Nutrition Examination Surveys, 1960-1991. JAMA 1994; 272:205-211.
4. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991-1998. JAMA 1999; 282:1519-1522.
5. Chaing BN, Perlman LV, Epstein FH. Overweight and hypertension. A review. Circulation 1969; 39:403-421.
6. Kannel WB, Brand N, Skinner JJ, Dawber TR, McNamara PM. The relation of adiposity to blood pressure and development of hypertension: The Framingham study. Ann Intern Med 1967; 67:48-59.
7. Levin BE, Stoddard-Apter S, Sullivan AC. Central activation and peripheral function of sympatho-adrenal and cardiovascular systems in the Zucker rat. Physiol Behav 1984; 32:295-299.
8. O'Donnell MP, Kasiske BL, Cleary MP, Keane WF. Effects of genetic obesity on renal structure and function in the Zucker rat. II. Micropuncture studies. J Lab Clin Med 1985; 106:605-610.
9. Todd EL, Abernethy DR. Pharmacokinetics and dynamics of (+) verapamil in lean and obese Zucker rats. J Pharm Exp Ther 1984; 238:642-647.
10. Bunag RD, Barringer DL. Obese Zucker rats, though still normotensive, already have impaired chronotropic baroreflexes. Clin Exp Hypertens [A] 1988; 10(Suppl 1):257-262.
11. Auguet M, Delaflotte S, Braquet P. Increased influence of endothelium in obese Zucker rat aorta. J Pharm Pharm 1989; 41:861-864.
12. Pawloski CM, Kanagy NL, Mortensen LH, Fink GD. Obese Zucker rats are normotensive on normal and increased sodium intake. Hypertension 1992; 19(Suppl 1):I-90-I-95.
13. Lavaud S, Michel O, Sassy-Prigent C, Heudes D, Bazin R, Bariety J, et al. Early influx of glomerular macrophages precedes glomerulosclerosis in the obese Zucker rat model. J Am Soc Nephrol 1996; 7:2604-2615.
14. Pamidimukkala J, Jandhyala BS. Evaluation of hemodynamics, vascular reactivity and baroreceptor compensation in the insulin resistant Zucker obese rats. Clin Exp Hypertens 1996; 18:1089-1104.
15. Wickler SJ, Horowitz BA, Stern JS. Regional blood flow in genetically-obese rats during nonshivering thermogenesis. Int J Obes 1982; 6:481-490.
16. Kasiske BL, Cleary MP, O'Donnell MP, Keane WF. Effects of genetic obesity on renal structure and function in the Zucker rat. J Lab Clin Med 1985; 106:598-604.
17. Paradise NF, Pilati CF, Payne WR, Finkelstein JA. Left ventricular function of the isolated, genetically obese rat's heart. Am J Physiol 1985; 248:H438-H444.
18. Kurtz TW, Morris RC, Pershadsingh HA. The Zucker rat as a genetic model of obesity and hypertension. Hypertension 1989; 13:896-901.
19. Zemel MB, Sowers JR, Shehin S, Walsh MF, Levy J. Impaired calcium metabolism associated with hypertension in Zucker obese rats. Metabolism 1990; 39:704-708.
20. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity. Hypertension 1996; 28:1047-1054.
21. Carlson SH, Shelton J, White CR, Wyss JM. Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats. Hypertension 2000; 35:403-408.
22. Dworkin LD, Feiner HD, Randazzo J. Glomerular hypertension and injury in desoxycorticosterone-salt rats on antihypertensive therapy. Kidney Int 1987; 31:718-724.
23. Gavras H, Brunner HR, Laragh JH, Vaughn ED, Koss M, Cote LJ, et al. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: Role of renid and sodium in vascular changes. Circ Res 1975; 36:300-309.
24. Kretzler M, Koeppen-Hagemann I, Kriz W. Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized-desoxycorticosterone hypertensive rat. Virchows Arch 1994; 425:181-193.
25. Wada T, Kanagawa R, Ishimura Y, Inada Y, Nishikawa K. Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats. J Hypertens 1995; 13:113-122.
26. Matsumura Y, Kuro T, Kobayashi Y, Konishi F, Takaoka M, Wessale JL, et al. Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension. Circulation 2000; 102:2765-2773.
27. Magil AB. Tubulointerstitial lesions in young Zucker rats. Am J Kid Dis 1995; 25:478-485.
28. Kasiske BL, O'Donnell MP, Cleary MP, Keane WF. Effects of reduced renal mass on tissue lipids and renal injury in hyperlipidemic rats. Kidney Int 1989; 35:40-47.
29. Shimamura T. Focal glomerulosclerosis in obese Zucker rats and prevention of its development. Kidney Int 1983; 24(Suppl 16):S-259-S-262.
30. Shimamura T. Prevention of 11-deoxycorticosterone-salt-induced glomerular hypertrophy and glomerulosclerosis by dietary phosphate binder. Am J Pathol 1990; 136:549-556.
31. Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, et al. Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats. Hypertension 1994; 24:195-204.
32. Chua SC, White DW, Wu-Peng XS, Liu SM, Okada N, Kershaw EE, et al. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 1996; 45:1141-1143.
33. Takaya K, Ogawa Y, Isse N, Okazaki T, Saroh N, Masuzaki H, et al. Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 1996; 225:75-83.
34. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997; 46:2040-2043.
35. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31 (part 2):409-414.
36. Fruhbeck G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 1999; 48:903-908.
37. Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin. Role of adrenergic activity. Hypertension 2002; 39(Pt 2):496-501.
38. Hall JE, Hildebrandt DA, Kuo J. Obesity hypertension: Role of leptin and sympathetic nervous system. Am J Hypertens 2001; 14:103S-115S.
39. Haynes WG. Interaction between leptin and the sympathetic nervous system in hypertension. Curr Hypertens Rep 2000; 2:311-318.
40. Villarreal D, Reams G, Freeman RH, Taraben A. Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol 1998; 275:R2056-R2060.